1-(甲基氨基)环丙烷羧酸 | 99324-92-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-(甲基氨基)环丙烷羧酸
• 英文名称: NSC 677915
• 英文别名: 1-(methylamino)cyclopropanecarboxylic acid；1-methylamino-cyclopropane-1-carboxylic acid；1-(Methylamino)cyclopropane-1-carboxylic acid
• CAS: 99324-92-2
• 化学式: C₅H₉NO₂
• 分子量: 115.132
• InChiKey: ZCLBLSZZIRMCLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(甲基氨基)环丙烷羧酸 在 盐酸 、 三甲基乙酰氯 、 potassium carbonate 作用下， 以 乙醚 、 氯仿 、 水 为溶剂， 反应 2.0h， 生成 methyl 1-[chloro(methyl)amino]cyclopropane-1-carboxylate
  参考文献：
  名称：

  Reaction of cyclopropanamines with hypochlorite

  摘要：

  DOI：

  10.1021/jo00269a014
• 作为产物：
  描述：

  Methyl 1-(N-benzyloxycarbonyl-N-methyl)aminocyclopropane-1-carboxylic acid 在 palladium on activated charcoal 氢氧化钾 、 水 、 氢气 作用下， 以 甲醇 、 乙醇 为溶剂， 25.0 ℃ 、151.99 kPa 条件下， 反应 21.5h， 生成 1-(甲基氨基)环丙烷羧酸
  参考文献：
  名称：

  1-Aminocylopropane-1-carboxylic acid derivatives as ligands at the glycine-binding site of the N-methyl-D-aspartate receptor

  摘要：

  Several 1-aminocyclopropane-1-carboxylic acid derivatives were prepared and tested for activity at the glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor complex. Structural modifications involved the amino group, the carboxylic function or position 2 of the ring. When tested in a [H-3]-MK-801 binding assay in the presence of glutamic acid, some of the compounds were able to activate the receptor. Two of them (3e and 6) are selective ligands for the glycine site of the NMDA receptor. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00005-6

文献信息

• [EN] ARYL AMIDE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE L'ARYLAMIDE KINASE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2015006100A1

  公开（公告）日：2015-01-15

  The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

  本公开涉及一般可抑制AAK1（适配器相关激酶1）的化合物，包括这些化合物的组合物，以及抑制AAK1的方法。
• Method of Inhibiting Ethylene Production in Plants
  申请人：Thrower Julie

  公开号：US20090011939A1

  公开（公告）日：2009-01-08

  Methods of inhibiting ethylene production in a plant are provided that involve contacting a plant or plant part with an inhibitor of 1-aminocyclopropane-1-carboxylic acid oxidase (ACCO). The methods can be used to delay fruit and vegetable ripening, flower opening, or senescence of cut flowers. Also described are kits including an ACCO inhibitor and a floral preservative.

  提供了抑制植物乙烯产生的方法，涉及将植物或植物部分与1-氨基环丙烷-1-羧酸氧化酶（ACCO）抑制剂接触。这些方法可用于延迟水果和蔬菜的成熟、花朵的开放，或者延缓切花的凋谢。还描述了包括ACCO抑制剂和花卉保鲜剂的试剂盒。
• 1-methylamino-cyclopropane-1-carboxylic acid derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US05041612A1

  公开（公告）日：1991-08-20

  New 1-methylamino-cyclopropane-1-carboxylic acid derivatives, processes for their preparation and their use as plant growth regulators are disclosed and claimed.

  本发明揭示并声称了新的1-甲基氨基环丙烷-1-羧酸衍生物，其制备过程以及它们作为植物生长调节剂的用途。
• ARYL LACTAM KINASE INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160152621A1

  公开（公告）日：2016-06-02

  The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

  本披露通常涉及可以抑制AAK1（适配器相关激酶1）的化合物，包含这些化合物的组合物，以及抑制AAK1的方法。
• General and Scalable Approach to Trifluoromethyl-Substituted Cyclopropanes
  作者：Volodymyr Ahunovych、Anton A. Klipkov、Maksym Bugera、Karen Tarasenko、Serhii Trofymchuk、Oleh Stanko、Andrii Boretskyi、Mykola Zheludenko、Iryna V. Sadkova、Pavel K. Mykhailiuk

  DOI：10.1021/acs.joc.3c00123

  日期：2023.3.17

  CF3-cyclopropanes with aliphatic, aromatic, and even heteroaromatic substituents were prepared on a multigram scale by deoxyfluorination of cyclopropane carboxylic acids or their salts with sulfur tetrafluoride. For labile α-pyridine acetic acids, only the use of their potassium salts allowed to obtain the needed products. Derivatization of CF3-cyclopropanes into building blocks ready for direct use

  通过环丙烷羧酸或其盐与四氟化硫的脱氧氟化，以多克规模制备了具有脂肪族、芳香族甚至杂芳族取代基的CF 3 -环丙烷。对于不稳定的α-吡啶乙酸，只有使用它们的钾盐才能获得所需的产品。将 CF 3 -环丙烷衍生为可直接用于药物化学的结构单元。