(6Z,9Z)-18-methoxyoctadeca-6,9-diene

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (6Z,9Z)-18-methoxyoctadeca-6,9-diene
• 英文别名: (6Z,9Z)-18-ethoxyoctadeca-6,9-diene
• 化学式: C₂₀H₃₈O
• 分子量: 294.521
• InChiKey: AUOVSPKRMUZAEI-MURFETPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  三乙基硅烷 、 亚油酸乙酯 在 C₂₄H₂₃ClCrIrNO₃ 、 四(3,5-二(三氟甲基)苯基)硼酸钠 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以22%的产率得到(6Z,9Z)-18-methoxyoctadeca-6,9-diene
  参考文献：
  名称：

  用于羰基和羧酸衍生物有效氢化硅烷化的多功能铱（III）金属环催化剂

  摘要：

  通用的Ir III金属环可快速，选择性地催化各种酯，羧酸，酮和醛的还原。该反应在室温下通过氢化硅烷化然后脱甲硅烷基化以高收率进行。取决于底物，酯被还原为醇或醚，而羧酸被还原为醇或醛。

  DOI：

  10.1002/ejoc.201700801

文献信息

• LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM
  申请人：BARYZA Jeremy

  公开号：US20110200582A1

  公开（公告）日：2011-08-18

  Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.

  本文披露了用于将生物活性剂量有效传递至肝脏、肿瘤和/或其他细胞或组织的配方和优化方案。还提供了具有化学式（I）的阳离子脂质化合物的组成和用途。该发明还涉及具有化学式（XI）的隐身脂质的组成和用途。还提供了制备这种化合物、组成物和配方的方法，以及利用这些化合物、组成物和配方将生物活性剂传递至细胞和/或组织的方法和用途。
• LIPIDS SUITABLE FOR LIPOSOMAL DELIVERY OF PROTEIN CODING RNA
  申请人：Geall Andrew

  公开号：US20130189351A1

  公开（公告）日：2013-07-25

  RNA is encapsulated within a liposome for in vivo delivery. The RNA encodes a polypeptide of interest, such as an immunogen for immunisation purposes. The liposome includes at least one compound selected from the group consisting of compounds of formula (I) and formula (XI).
• US9301923B2
  申请人：——

  公开号：US9301923B2

  公开（公告）日：2016-04-05
• [EN] LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM<br/>[FR] LIPIDES, COMPOSITIONS LIPIDIQUES, ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：NOVARTIS AG

  公开号：WO2011076807A2

  公开（公告）日：2011-06-30

  Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (Xl). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.
• A Versatile Iridium(III) Metallacycle Catalyst for the Effective Hydrosilylation of Carbonyl and Carboxylic Acid Derivatives
  作者：Yann Corre、Vincent Rysak、Xavier Trivelli、Francine Agbossou-Niedercorn、Christophe Michon

  DOI：10.1002/ejoc.201700801

  日期：2017.9.1

  IrIII metallacycle rapidly and selectively catalyses the reduction of various esters, carboxylic acids, ketones, and aldehydes. The reactions proceed in high yields at room temperature by hydrosilylation followed by desilylation. Depending on the substrate, esters are reduced to alcohols or ethers and carboxylic acids to alcohols or aldehydes.

  通用的Ir III金属环可快速，选择性地催化各种酯，羧酸，酮和醛的还原。该反应在室温下通过氢化硅烷化然后脱甲硅烷基化以高收率进行。取决于底物，酯被还原为醇或醚，而羧酸被还原为醇或醛。