N,N'-二乙酰基乙二胺 | 5335-91-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N,N'-二乙酰基乙二胺
• 中文别名: N,N'-二乙酰乙二胺
• 英文名称: 1,1-bis-acetylamino-ethane
• 英文别名: 1,1-Bis-acetylamino-aethan；ethylidene-bis-acetamide；ethylidene bisacetamide；Acetamide, N,N'-ethylidenebis-；N-(1-acetamidoethyl)acetamide
• CAS: 5335-91-1
• 化学式: C₆H₁₂N₂O₂
• 分子量: 144.173
• InChiKey: SJSZBOAQWPKFMU-UHFFFAOYSA-N

物化性质

• 熔点：
  170 °C
• 沸点：
  411.3±28.0 °C(Predicted)
• 密度：
  1.031±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  N,N'-二乙酰基乙二胺 在 盐酸 、 溶剂黄146 、 三氯化磷 作用下， 生成 DL-1-氨基乙基膦酸
  参考文献：
  名称：

  Soroka, Miroslaw; Jaworska, Dorota; Szczesny, Zbigniew, Liebigs Annalen der Chemie, 1990, # 11, p. 1153 - 1155

  摘要：

  DOI：
• 作为产物：
  描述：

  N-Acetyliminodiethylsulfuran 生成 N,N'-二乙酰基乙二胺
  参考文献：
  名称：

  Iminosulfuranes (sulfilimines). V. Thermolysis of N-acetyliminodialkylsulfuranes

  摘要：

  DOI：

  10.1021/jo00973a011

文献信息

• Insulin Derivatives Conjugated with Structurally Well Defined Branched Polymers
  申请人：Behrens Carsten

  公开号：US20090036353A1

  公开（公告）日：2009-02-05

  Insulin conjugated with structurally well defined, bifurcated and trifurcated polymers can be use by pulmonary delivery for systemic absorption through the lungs to reduce or eliminate the need for administering other insulins by injection.

  胰岛素与结构明确定的双分支和三分支聚合物结合后，可以通过肺部给药进行系统吸收，从而减少或消除通过注射给予其他胰岛素的需要。
• Production of N-vinyl carboxylic acid amides
  申请人：Celanese Corporation

  公开号：US04554377A1

  公开（公告）日：1985-11-19

  The invention relates to the preparation of N-.alpha.-alkoxyethyl-carboxylic acid amides from dimethyl acetal and a carboxylic acid amide such as acetamide and to the preparation of secondary N-vinyl carboxylic acid amides such as N-vinyl acetamide therefrom. The reaction of dimethyl acetal and the carboxylic acid amide involves an equilibrium disproportionation wherein excess dimethyl acetal is used in sufficient amounts, e.g., in a molar ratio of from about 2 to 60:1 mole ratio, so as to force the equilibrium to the desired N-.alpha.-alkoxyethyl-carboxylic acid amide intermediate product. Equilibrium is reached in about 0.1 to 150 hours at a temperature about 0.degree. to 100.degree. C. The intermediate N-.alpha.-alkoxyethyl-carboxylic acid amide is pyrolyzed in accordance with a known pyrolysis reaction so as to obtain the corresponding N-vinyl acetamide.

  该发明涉及从二甲基缩醛和羧酸酰胺（如乙酰胺）制备N-α-烷氧乙基羧酸酰胺，以及制备次级N-乙烯基羧酸酰胺（如N-乙烯基乙酰胺）的方法。二甲基缩醛和羧酸酰胺的反应涉及一个平衡不均反应，其中过量的二甲基缩醛以足够的量使用，例如，摩尔比为2:1至60:1，以将平衡推向所需的N-α-烷氧乙基羧酸酰胺中间体产物。平衡在约0.1至150小时内达到，在温度约0摄氏度至100摄氏度。根据已知的热解反应，将中间体N-α-烷氧乙基羧酸酰胺进行热解，以获得相应的N-乙烯基乙酰胺。
• Reactions of ethylidene diacetate: Formation of N-vinylamide precursors ethylidene bisacetamide and ethylidene bisformamide
  作者：John J. Rabasco、Francis J. Waller

  DOI：10.1016/s0040-4039(97)01089-7

  日期：1997.7

  Ethylidene diacetate (EDA) reacts with formamide or acetamide under stoichiometric base or catalytic Lewis acid conditions to afford the corresponding ethylidene bisamides and N-vinylamides. Sn(OAc)2 afforded an overall 82.6% selectivity to the desired acetamide derivatives. Sn(OAc)2 and Zn(OAc)2 facilitate amide attack at the tertiary carbon of EDA.

  亚乙二乙酸酯（EDA）在化学计量的碱或催化的路易斯酸条件下与甲酰胺或乙酰胺反应，得到相应的亚乙基双酰胺和N-乙烯基酰胺。Sn（OAc）2对所需乙酰胺衍生物的总选择性为82.6％。Sn（OAc）2和Zn（OAc）2促进酰胺对EDA叔碳的攻击。
• Method for lowering serum glucose
  申请人：GelTex Pharmaceutical, Inc.

  公开号：US20020187121A1

  公开（公告）日：2002-12-12

  A method for treating hyperglycemia and/or reducing serum glucose levels in a patient that includes administering to the patient a therapeutically effective amount of an amine polymer is disclosed. In one embodiment, the amine polymer is aliphatic. Examples of polymers useful in an embodiment of the invention include sevelamer hydrogen chloride and colesevelam. The invention includes the use of amine polymers such as a cross-linked polymer characterized by a repeat unit having the formula: 1 and salts and copolymers thereof, where n is a positive integer and x is zero or an integer between 1 and about 4. Also described is a use, for the manufacture of a medicament, of a polymer that lowers serum glucose.

  本发明公开了一种治疗高血糖和/或降低患者血清葡萄糖水平的方法，包括向患者投予治疗有效量的胺基聚合物。在一种实施例中，胺基聚合物是脂肪族的。本发明的实施例中有用的聚合物的例子包括盐酸西韦拉酰胺和考来西韦。本发明包括使用胺基聚合物，例如交联聚合物，其特征在于重复单元具有公式1，以及其盐和共聚物，其中n是正整数，x为零或介于1和约4之间的整数。本发明还描述了一种用于制造药物的降低血清葡萄糖的聚合物的用途。
• Process for removing bile salts from a patient and alkylated compositions therefor
  申请人：GelTex Pharmaceuticals, Inc.

  公开号：US20010044519A1

  公开（公告）日：2001-11-22

  The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of a salt of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer salt comprises the reaction product of crosslinked polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent.

  本发明涉及一种从需要去除胆盐的患者中去除胆盐的方法和有用的组合物。该方法包括向患者施用一种烷基化和交联聚合物的盐的治疗有效量。烷基化和交联聚合物盐包括交联聚合物的反应产物，或其盐和共聚物，其中具有胺含有重复单元，并与至少一种脂肪族烷基化剂反应。