2,2-diallyl acetamide | 60730-94-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-diallyl acetamide
• 英文别名: diallylacetamide；2-allyl-pent-4-enoic acid amide；2-Allyl-pent-4-ensaeure-amid；α,α-Diallylacetamid；Diallylacetamid；4-Pentenamide, 2-(2-propen-1-yl)-；2-prop-2-enylpent-4-enamide
• CAS: 60730-94-1
• 化学式: C₈H₁₃NO
• mdl: MFCD19203550
• 分子量: 139.197
• InChiKey: JYFZEIOJVVOTPN-UHFFFAOYSA-N

物化性质

• 沸点：
  255.17°C (rough estimate)
• 密度：
  1.0268 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,2-diallyl acetamide 在 乙醇 、 sodium 、 phosphorus pentoxide 作用下， 生成 2-allylpent-4-en-1-amine
  参考文献：
  名称：

  Oberreit, Chemische Berichte, 1896, vol. 29, p. 2000

  摘要：

  DOI：
• 作为产物：
  描述：

  丙戊酸相关物质A 在 氨 作用下， 生成 2,2-diallyl acetamide
  参考文献：
  名称：

  Oberreit, Chemische Berichte, 1896, vol. 29, p. 2000

  摘要：

  DOI：

文献信息

• Hindered Amine salt compounds
  申请人：Wood Marvin G.

  公开号：US20080221332A1

  公开（公告）日：2008-09-11

  The present invention relates water-soluble hindered amine compounds of the general formula (I): wherein G 1 and G 2 are independently alkyl of 1 to 4 carbon atoms or are together pentamethylene; Z 1 and Z 2 are each methyl, or Z 1 and Z 2 together form an unsubstituted linking moiety or a linking moiety substituted by one or more groups selected from an ester, ether, hydroxy, oxo, cyanohydrin, amide, amino, carboxy or an urethane group; E is alkoxy of 1 to 18 carbon atoms, cycloalkoxy of 5 to 12 carbon atoms or aralkoxy of 7 to 15 carbon atoms, or E is —O-T-(OH) b ; T is a straight or branched chain alkylene of 1 to 18 carbon atoms, cycloalkylene of 5 to 18 carbon atoms, cycloalkenylene of 5 to 18 carbon atoms, a straight or branched chain alkylene of 1 to 4 carbon atoms substituted by phenyl or by phenyl substituted by one or two alkyl groups of 1 to 4 carbon atoms; b is 1, 2 or 3 with the proviso that b cannot exceed the number of carbon atoms in T, and when b is 2 or 3, each hydroxyl group is attached to a different carbon atoms of T; and, HY is an inorganic or organic acid; and, wherein the total charge of cations is equal to the total charge of anions.

  本发明涉及一般式(I)的水溶性受阻胺化合物：其中G1和G2分别是1至4个碳原子的烷基，或者一起是戊亚甲基；Z1和Z2分别是甲基，或者Z1和Z2一起形成一个未取代的连接基或一个由酯、醚、羟基、酮基、氰水合物、酰胺、氨基、羧基或脲基中选择的一个或多个基团取代的连接基；E是1至18个碳原子的烷氧基，5至12个碳原子的环烷氧基或7至15个碳原子的芳基氧基，或者E是—O-T-(OH)b；T是1至18个碳原子的直链或支链烷基，5至18个碳原子的环烷基，5至18个碳原子的环烯基，1至4个碳原子的直链或支链烷基，其被苯基取代，或者被一个或两个1至4个碳原子的烷基取代的苯基取代；b是1、2或3，但b不能超过T中的碳原子数，当b为2或3时，每个羟基连接到T的不同碳原子；HY是无机或有机酸；总阳离子电荷等于总阴离子电荷。
• NEW 5-ALKYNYL-PYRIDINES
  申请人：Dreyer Alexander

  公开号：US20120196872A1

  公开（公告）日：2012-08-02

  The present invention relates to new CGRP-antagonists of general formula I wherein R 1 , R 2 , R 3 , R a , R b , R c , X, Y and Z are defined as mentioned hereinafter, the individual diastereomers, the individual enantiomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing these compounds, the use thereof and processes for the preparation thereof.

  本发明涉及一般式I的新的CGRP拮抗剂，其中R1、R2、R3、Ra、Rb、Rc、X、Y和Z的定义如下所述，各个对映体、各个对映体和其盐，特别是其与无机或有机酸或碱形成的生理上可接受的盐，含有这些化合物的药物、其用途以及其制备方法。
• Process for the production of monoalkyltin trihalides
  申请人：Atofina Vlissingen B.V.

  公开号：EP1225177A1

  公开（公告）日：2002-07-24

  The present invention is directed to a process for the production of monoalkyltin trihalides of the formula RSnX3, wherein R = alkyl or cycloalkyl and X = Cl, Br or I, involving a redistribution reaction between tetraorganotins, triorganotin halides or diorganotin halides and tin tetrahalides, said process comprising contacting tetra- (R4Sn), tri- (R3SnX) or diorganotin halides (R2SnX2) with SnX4 to afford said monoorganotin trihalides in the presence of at least one transition metal complex, said complex comprising at least one transition metal, M, selected from Group VIII of the periodic Table of elements, at least one monodentate ligand or bidentate ligand, L, L' or L", and optionally one or more anions, X, of an organic or inorganic acid, as a catalyst or catalyst precursor.

  本发明涉及一种用于生产公式RSnX3的单烷基锡三卤化物的方法，其中R = 烷基或环烷基，X = Cl、Br或I，涉及四有机锡化合物、三有机锡卤化物或二有机锡卤化物与锡四卤化物之间的重新分配反应，所述方法包括将四有机锡化合物（R4Sn）、三有机锡卤化物（R3SnX）或二有机锡卤化物（R2SnX2）与SnX4接触，以在至少一种过渡金属配合物的存在下生成所述单有机锡三卤化物，所述配合物包括来自元素周期表第VIII族的至少一种过渡金属M，至少一种一齿配体或二齿配体L、L'或L"，以及作为催化剂或催化剂前体的有机或无机酸的一个或多个阴离子X。
• [EN] PROCESS FOR THE PREPARATION OF MACITENTAN AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE MACITENTAN ET D'INTERMÉDIAIRES DE CE DERNIER
  申请人：MEGAFINE PHARMA (P) LTD

  公开号：WO2016203489A1

  公开（公告）日：2016-12-22

  The present invention relates to an improved process for preparation of Macitentan and intermediates thereof. The present invention also relates to a novel ammonium salt of Macitentan. The present invention further relates to a process for the preparation of amorphous Macitentan.

  本发明涉及一种改进的制备马西替坦及其中间体的方法。本发明还涉及马西替坦的一种新型铵盐。本发明还涉及一种制备非晶态马西替坦的方法。
• [EN] AN IMPROVED PROCESS FOR PREPARING VILDAGLIPTIN<br/>[FR] PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DE VILDAGLIPTINE
  申请人：LAURUS LABS PRIVATE LTD

  公开号：WO2015145467A1

  公开（公告）日：2015-10-01

  The present invention relates to efficient, environment friendly and economical processes for the preparation of vildagliptin without isolating the intermediate compounds. Also provided is a process for the recovery of expensive 1-aminoadamantane-3-ol and use thereof in the preparation of vildagliptin.

  本发明涉及一种高效、环保和经济的维达格列汀制备过程，无需分离中间化合物。同时提供了一种用于回收昂贵的1-氨基金刚烷-3-醇并将其用于维达格列汀制备的过程。