6-(dodecyloxy)-6-oxohexan-1-aminium chloride

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(dodecyloxy)-6-oxohexan-1-aminium chloride
• 英文别名: (6-Dodecoxy-6-oxohexyl)azanium;chloride；(6-dodecoxy-6-oxohexyl)azanium;chloride
• 化学式: C₁₈H₃₇NO₂*ClH
• 分子量: 335.958
• InChiKey: YZWPMRNJTGXVDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.39
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(dodecyloxy)-6-oxohexan-1-aminium chloride 在 三乙胺 作用下， 以 乙醚 、 水 为溶剂， 反应 0.25h， 生成 十二烷基6-氨基己酸酯
  参考文献：
  名称：

  Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation

  摘要：

  Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.077
• 作为产物：
  描述：

  十二烷基6-氨基己酸酯 在 盐酸 作用下， 以 水 为溶剂， 生成 6-(dodecyloxy)-6-oxohexan-1-aminium chloride
  参考文献：
  名称：

  [EN] SURFACTANTS FOR HEALTHCARE PRODUCTS
  [FR] TENSIOACTIFS POUR PRODUITS DE SOINS DE SANTÉ

  摘要：

  医疗保健配方，包括创新表面活性剂，活性成分制剂为固体、液体或乳液。本公开提供医疗保健产品的配方，如：处方药、非处方药；矿物质、草药和/或维生素补充剂；在医院、诊所、医生办公室和临终关怀场所使用的药物；疫苗、组织、器官和细胞移植和/或移植和/或输注；以及包括局部药膏、乳液、清洁剂、湿巾、绷带和敷料的伤口护理配方。活性成分可以作为溶质、溶剂、颗粒或配方中的油不相溶成分包含在配方中。活性成分可以包含在片剂、胶囊、药液或乳剂中。创新的医疗保健配方包括适用于口服、局部和/或注射的配方。

  公开号：

  WO2021183582A1

文献信息

• [EN] SURFACTANTS FOR ELECTRONICS PRODUCTS<br/>[FR] TENSIOACTIFS POUR PRODUITS ELECTRONIQUES
  申请人：ADVANSIX RESINS & CHEMICALS LLC

  公开号：WO2021183581A1

  公开（公告）日：2021-09-16

  Pre-texturing agents, etchants, and photoresist stripping agents may be formulated to include one or more surfactants, from one or more surfactant classes, such as derivatives of amino acids that have surface-active properties.

  预贴图剂、蚀刻剂和光刻胶去除剂可以配制成包含一种或多种表面活性剂，来自一种或多种表面活性剂类别，例如具有表面活性特性的氨基酸衍生物。
• [EN] SURFACTANTS FOR AGRICULTURAL PRODUCTS<br/>[FR] TENSIOACTIFS POUR PRODUITS AGRICOLES
  申请人：ADVANSIX RESINS & CHEMICALS LLC

  公开号：WO2021183560A1

  公开（公告）日：2021-09-16

  Agricultural products, such as pesticides, plant growth regulators, fungicides, herbicides, and insecticides, may be formulated to include one or more surfactants, from one or more surfactant classes, such as derivatives of amino acids that have surface-active properties.

  农业产品，如杀虫剂、植物生长调节剂、杀菌剂、除草剂和杀虫剂，可以配制成包含一种或多种表面活性剂的配方，来自一种或多种表面活性剂类别，例如具有表面活性特性的氨基酸衍生物。
• [EN] SURFACTANTS FOR HEALTHCARE PRODUCTS<br/>[FR] TENSIOACTIFS POUR PRODUITS DE SOINS DE SANTÉ
  申请人：ADVANSIX RESINS & CHEMICALS LLC

  公开号：WO2021183582A1

  公开（公告）日：2021-09-16

  Healthcare formulations, including, inventive surfactants, Active ingredient formulated as solids, liquids, or emulsions. The present disclosure provides formulations of healthcare products, such as: prescription drugs, over the counter drugs; minerals, herbal, and/or vitamin supplements; drugs administered in hospitals, clinics, physician's office, and places of palliative care; vaccines, tissue, organ, and cell transplants and/or grafts and/or infusions; and wound care formulations including topical ointments, lotions, cleaners, wipes, bandages, and dressings. The Active may be included in the formulations as a solute, a solvent, a particle, or an oil immiscible component of the formulation. The Active may be included in tablets, capsules, tinctures, liquids, or emulsions. Inventive healthcare formulations include formulations suitable for administration orally, topically, and/or by injection.

  医疗保健配方，包括创新表面活性剂，活性成分制剂为固体、液体或乳液。本公开提供医疗保健产品的配方，如：处方药、非处方药；矿物质、草药和/或维生素补充剂；在医院、诊所、医生办公室和临终关怀场所使用的药物；疫苗、组织、器官和细胞移植和/或移植和/或输注；以及包括局部药膏、乳液、清洁剂、湿巾、绷带和敷料的伤口护理配方。活性成分可以作为溶质、溶剂、颗粒或配方中的油不相溶成分包含在配方中。活性成分可以包含在片剂、胶囊、药液或乳剂中。创新的医疗保健配方包括适用于口服、局部和/或注射的配方。
• [EN] SURFACTANTS FOR PERSONAL CARE AND COSMETIC PRODUCTS<br/>[FR] TENSIOACTIFS POUR PRODUITS COSMÉTIQUES ET DE SOINS PERSONNELS
  申请人：ADVANSIX RESINS & CHEMICALS LLC

  公开号：WO2021183562A1

  公开（公告）日：2021-09-16

  Personal care products, such as shampoos, conditioners, hair dyes, hair removal products, cleansers, cosmetics, mascaras, and toothpastes may be formulated to include one or more surfactants, from one or more surfactant classes, such as derivatives of amino acids that have surface-active properties.

  个人护理产品，如洗发水、护发素、染发剂、脱毛产品、洁面乳、化妆品、睫毛膏和牙膏等，可能会配制含有一种或多种表面活性剂，来自一种或多种表面活性剂类别，比如具有表面活性性质的氨基酸衍生物。
• SURFACTANTS FOR INKS, PAINTS, AND ADHESIVES
  申请人：AdvanSix Resins & Chemicals LLC

  公开号：US20210292583A1

  公开（公告）日：2021-09-23

  Inks, paints, adhesives, and paint strippers may be formulated to include one or more surfactants, from one or more surfactant classes, such as derivatives of amino acids that have surface-active properties.