N-Acetyl-N-methylcarbamoyl chloride | 21777-48-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acetyl-N-methylcarbamoyl chloride
• CAS: 21777-48-0
• 化学式: C₄H₆ClNO₂
• 分子量: 135.55
• InChiKey: XHLLMVSEBKZODD-UHFFFAOYSA-N

物化性质

• 沸点：
  62-63 °C(Press: 13 Torr)
• 密度：
  1.2649 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-Acetyl-N-methylcarbamoyl chloride 、 2-mercaptopyridine-1-oxide sodium salt 以 苯 为溶剂， 反应 1.5h， 生成 1-<(N-Acetyl-N-methylcarbamoyl)oxy>-2(1H)-pyridinethione
  参考文献：
  名称：

  N-Acyl-N-alkylcarbamoyloxy radicals: Entries to amidyl radicals by decar☐ylation and to α-amide radicals by radical translocation

  摘要：

  N'-Acyl-N-hydroxypyridine-2-thione carbamates react in radical chain reactions to give the title radicals which can decarboxylate or react by intramolecular hydrogen atom transfer; the competing reaction pathways are controlled by the structure of the alkyl group and the conformation of the precursor which can be influenced by addition of a Lewis acid.

  DOI：

  10.1016/s0040-4039(00)61087-0
• 作为产物：
  描述：

  N-甲基乙酰胺 、 光气 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 N-Acetyl-N-methylcarbamoyl chloride
  参考文献：
  名称：

  Valcavi; Brandt; Corsi, Farmaco, Edizione Scientifica, 1980, vol. 35, # 7, p. 563 - 572

  摘要：

  DOI：

文献信息

• .alpha.-Acylureidocephalosporins and salts and esters thereof
  申请人：Beecham Group Limited

  公开号：US04312982A1

  公开（公告）日：1982-01-26

  Compounds which are clinically important cephalosporins and salts and esters thereof having a wide spectrum of activity against Gram-positive bacteria but especially against Gram-negative bacteria such as Pseudomonas spp. against which commercially available cephalosporins are normally inactive. Preferred compounds of the invention are also active against Gram-negative cephalosporinase-producing organisms such as Enterobacter spp., Serratia spp. and indole-positive Proteus; methods of preparation are described.

  这是一段医学方面的内容，翻译如下： 这些化合物是临床上重要的头孢菌素，它们的盐和酯具有广谱的抗菌活性，对革兰氏阳性菌尤其有效，但对革兰氏阴性菌如假单胞菌等也具有活性，而商业上可获得的头孢菌素通常无法对其产生作用。该发明的首选化合物也对产生头孢菌素酶的革兰氏阴性菌如肠杆菌属、沙雷氏菌属和靛阳性变形菌等具有活性；同时，还描述了制备方法。
• 2-Oxo-3 thiazoline-oximes as pesticides
  申请人：Hoffmann-La Roche Inc.

  公开号：US04255436A1

  公开（公告）日：1981-03-10

  Carbamoyl-oximes of the formula ##STR1## wherein R.sub.1 and R.sub.3 each are lower alkyl, lower alkenyl, cycloalkyl, aryl or halogen-substituted aryl; R.sub.2 is lower alkyl; R.sub.4 is lower alkyl or cycloalkyl; and R.sub.5 is hydrogen, lower alkyl, lower alkylcarbonyl or halogen-substituted lower alkylcarbonyl, and acid addition salts of these compounds, a process for their preparation, pesticidal compositions containing one or more of these compounds as the active ingredient and methods for the use of such compositions for the control of pests.

  式为##STR1##的羰基肟，其中R.sub.1和R.sub.3分别为低烷基，低烯基，环烷基，芳基或卤素取代的芳基；R.sub.2为低烷基；R.sub.4为低烷基或环烷基；R.sub.5为氢，低烷基，低烷基羰基或卤素取代的低烷基羰基，并且这些化合物的酸加成盐，其制备方法，含有这些化合物作为活性成分的杀虫剂组合物以及使用这些组合物控制害虫的方法。
• 2-Oximino-tetrahydro-1,4-thiazin-5-one compounds and pesticidal
  申请人：Union Carbide Corporation

  公开号：US04071627A1

  公开（公告）日：1978-01-31

  2-Oximino-tetrahydro-1,4-thiazin-5-one compounds are useful as intermediates in the preparation of 2-carbamoyloximino-tetrahydro-1,4-thiazin-5-one carbamate compounds that exhibit outstanding pesticidal activity.

  2-氧肟基-四氢-1,4-噻唑-5-酮化合物是制备具有优异杀虫活性的2-氨基甲酰氧基-四氢-1,4-噻唑-5-酮氨甲酸酯化合物的中间体。
• Multiple Reaction Channels of (N-Acyl-N-alkylcarbamoyl)oxyl Radicals from N-Acyl PTOC Carbamates
  作者：John L. Esker、Martin Newcomb

  DOI：10.1021/jo00089a023

  日期：1994.5

  N-Acyl-N-alkyl-N'-hydroxypyridine-2-thione carbamates (N-acyl PTOC carbamates) 1 are prepared in good to excellent yield by reactions of N-acylcarbamoyl chlorides with N-hydroxypyridine-2-thione sodium salt. Methods for production of the requisite carbamoyl chlorides by reaction of a secondary amide with trimethylsilyl triflate followed by treatment with phosgene were optimized. Precursors 1 react in radical chain reactions to give the title radicals (2) that can further react by several pathways. Decarboxylations of radicals 2 give amidyl radicals, and this method is excellent for production of acetamidyl radicals and in particular the N-methylacetarnidyl radical which is difficult to prepare by other routes. 5-Exo cyclizations of amidyl radicals produced by decarboxylation of 2 give, ultimately, lactams and N-acylpyrrolidines. 1,5-Hydrogen transfer reactions of 2 to give alpha-amide radicals compete with decarboxylation; cyclization of an alpha-amide radical thus formed also is reported. The Lewis acid MgBr2 can reduce the 1,5-hydrogen atom transfer reaction apparently by a chelation effect on the precursor that leads to production of radical 2 in a conformation unfavorable for hydrogen atom transfer. By appropriate experimental design, radicals 2 often can be directed toward one desired reaction, and several relative rate constants for reactions of 2 necessary for such design were determined in this work.
• Mironov,V.F. et al., Doklady Chemistry, 1970, vol. 192, # 5, p. 425 - 428
  作者：Mironov,V.F. et al.

  DOI：——

  日期：——