3,4,5-tris(octadecyloxy)benzaldehyde | 348135-54-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3,4,5-tris(octadecyloxy)benzaldehyde
• 英文别名: 3,4,5-trioctadecyloxybenzaldehyde；3,4,5-trioctadecoxybenzaldehyde
• CAS: 348135-54-6
• 化学式: C₆₁H₁₁₄O₄
• 分子量: 911.574
• InChiKey: HUGGTAZJYSLOLE-UHFFFAOYSA-N

物化性质

• 沸点：
  863.5±60.0 °C(Predicted)
• 密度：
  0.898±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  27.8
• 重原子数：
  65
• 可旋转键数：
  55
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,4,5-tris(octadecyloxy)benzaldehyde 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 以100 %的产率得到3,4,5-tris(octadecyloxy)benzyl alcohol
  参考文献：
  名称：

  CN116573992

  摘要：

  公开号：
• 作为产物：
  描述：

  3,4,5-tris(octadecyloxy)benzyl alcohol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以87%的产率得到3,4,5-tris(octadecyloxy)benzaldehyde
  参考文献：
  名称：

  一种用于构建组合肽文库的新型保护基团

  摘要：

  3,4,5-三（十八烷氧基）苄醇，HO-Bzl(OC18)3，由没食子酸和十八烷基溴制备。使用常规的逐步延伸，合成了 N，C 保护的肽，Fmoc–AAn–...–AA1–OBzl(OC18)3。通过用乙酸乙酯中的 4 M 氯化氢处理选择性地裂解取代的苄酯，得到 Fmoc-AAn-...-AA1-OH 和 HO-Bzl(OC18)3。因此，取代的苄基可有效保护液相肽合成中的 C 端羧基。由于取代的苄基具有较高的分子量，Fmoc–AAn–...–AA1–OBzl(OC18)3 可以很容易地通过尺寸排阻色谱纯化；所有受保护的肽都在 Sephadex LH-20 凝胶过滤柱的空隙部分洗脱。

  DOI：

  10.1246/bcsj.74.733

文献信息

• <i>Meso</i>-Substituted Liquid Porphyrins
  作者：Agnieszka Nowak-Król、Dorota Gryko、Daniel T. Gryko

  DOI：10.1002/asia.200900693

  日期：2010.4.1

  Meso‐substituted A4‐porphyrins bearing 3,4,5‐trialkoxyphenyl substituents are efficiently synthesized and characterized. Porphyrins bearing twelve C10 and C11 alkyl chains turned out to be liquid at room temperature. The remaining porphyrins, bearing C8, C9, C12, and C18 alkyl chains, have low melting points and high solubility in nonpolar solvents. Their differential scanning calorimetry distinctly

  高效合成并表征了带有3,4,5-三烷氧基苯基取代基的内消旋A 4卟啉。带有十二个C10和C11烷基链的卟啉在室温下变成液态。其余带有C8，C9，C12和C18烷基链的卟啉具有低熔点和在非极性溶剂中的高溶解度。在大多数情况下，它们的差示扫描量热法清楚地显示出只有一个相变。
• CHALCONE DERIVATIVE COMPOUNDS
  申请人：NIPPON OIL AND FATS COMPANY, LIMITED

  公开号：EP0328669A1

  公开（公告）日：1989-08-23

  Chalcone derivative compounds represented by general formula (I) or (II), wherein R₁ and R₂ each represents a ha­logen atom, a hydroxy group, an amino group, a dimethylamino group, a nitro group, a cyano group, a phenyl group, an acetyl group, an alkyl group containing 1 to 18 carbon atoms or an alkyloxy group containing 1 to 22 carbon atoms, n₁ and n₂ each represents an integer of 0 to 21, and m₁ and m₂ each represents an integer of 0 to 5.

  通式(I)或(II)代表的查耳酮衍生物化合物，其中 R₁ 和 R₂ 各自代表卤素原子、羟基、氨基、二甲基氨基、硝基、氰基、苯基、乙酰基、含 1 至 18 个碳原子的烷基或含 1 至 22 个碳原子的烷氧基，n₁ 和 n₂ 各自代表整数、乙酰基、含 1 至 18 个碳原子的烷基或含 1 至 22 个碳原子的烷氧基，n₁ 和 n₂ 各自代表 0 至 21 的整数，m₁ 和 m₂ 各自代表 0 至 5 的整数。
• METHOD OF CHEMICAL SUBSTANCE SEPARATION
  申请人：Tokyo University of Agriculture and Technology Tlo Co., Ltd.

  公开号：EP1717581A1

  公开（公告）日：2006-11-02

  The present invention provides a method of separating substances utilizing a solid phase wherein a substance fixed to a solid phase can be easily separated without the application of a chemical process, biochemical process, exposure to light, electrical excitation, or the like. Disclosed is a method of separating a reaction product generated by the reaction of a first substance and a second substance comprising the steps of: (a) mixing the first substance with a temperature-sensitive carrier residing in a liquid-phase state; (b) fixing an anchor region of the first substance to the temperature-sensitive carrier by converting the temperature-sensitive carrier to a solid-phase state by changing the temperature of the reaction system; (c) generating a reaction product by reacting the second substance with a reaction region of the first substance that is fixed to the temperature-sensitive carrier; (d) removing impurities from the reaction system; and (e) releasing the anchor region of the reaction product from the temperature-sensitive carrier by converting the temperature-sensitive carrier to a liquid-phase state by changing the temperature of the reaction system.

  本发明提供了一种利用固相分离物质的方法，在这种方法中，固定在固相上的物质可以很容易地分离出来，而无需应用化学过程、生物化学过程、光照、电激发或类似方法。本发明公开了一种分离由第一种物质和第二种物质反应生成的反应产物的方法，包括以下步骤(a) 将第一种物质与处于液相状态的感温载体混合； (b) 通过改变反应体系的温度，将感温载体转换为固相状态，从而将第一种物质的锚区固定在感温载体上；(c) 第二种物质与固定在感温载体上的第一种物质的反应区反应，生成反应产物； (d) 去除反应体系中的杂质；以及 (e) 通过改变反应体系的温度，将感温载体转换为液相状态，从而将反应产物的锚区从感温载体上释放。
• Method of Chemical Substance Separation
  申请人：Chiba Kazuhiro

  公开号：US20080017585A1

  公开（公告）日：2008-01-24

  The present invention provides a method of separating substances utilizing a solid phase wherein a substance fixed to a solid phase can be easily separated without the application of a chemical process, biochemical process, exposure to light, electrical excitation, or the like. Disclosed is a method of separating a reaction product generated by the reaction of a first substance and a second substance comprising the steps of: (a) mixing the first substance with a temperature-sensitive carrier residing in a liquid-phase state; (b) fixing an anchor region of the first substance to the temperature-sensitive carrier by converting the temperature-sensitive carrier to a solid-phase state by changing the temperature of the reaction system; (c) generating a reaction product by reacting the second substance with a reaction region of the first substance that is fixed to the temperature-sensitive carrier; (d) removing impurities from the reaction system; and (e) releasing the anchor region of the reaction product from the temperature-sensitive carrier by converting the temperature-sensitive carrier to a liquid-phase state by changing the temperature of the reaction system.
• A Novel Protecting Group for Constructing Combinatorial Peptide Libraries
  作者：Hitoshi Tamiaki、Tomoyuki Obata、Yasuo Azefu、Kazunori Toma

  DOI：10.1246/bcsj.74.733

  日期：2001.4

  5-Tris(octadecyloxy)benzyl alcohol, HO–Bzl(OC18)3, was prepared from gallic acid and stearyl bromide. Using conventional step-wise elongation, N,C-protected peptides, Fmoc–AAn–...–AA1–OBzl(OC18)3, were synthesized. The substituted benzyl esters were selectively cleaved by a treatment with 4 M hydrogen chloride in ethyl acetate to give Fmoc–AAn–...–AA1–OH and HO–Bzl(OC18)3. Thus, the substituted benzyl group is effective

  3,4,5-三（十八烷氧基）苄醇，HO-Bzl(OC18)3，由没食子酸和十八烷基溴制备。使用常规的逐步延伸，合成了 N，C 保护的肽，Fmoc–AAn–...–AA1–OBzl(OC18)3。通过用乙酸乙酯中的 4 M 氯化氢处理选择性地裂解取代的苄酯，得到 Fmoc-AAn-...-AA1-OH 和 HO-Bzl(OC18)3。因此，取代的苄基可有效保护液相肽合成中的 C 端羧基。由于取代的苄基具有较高的分子量，Fmoc–AAn–...–AA1–OBzl(OC18)3 可以很容易地通过尺寸排阻色谱纯化；所有受保护的肽都在 Sephadex LH-20 凝胶过滤柱的空隙部分洗脱。