2,6-diamino-4-phenylpyridine-3,5-dicarbonitrile | 96461-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-diamino-4-phenylpyridine-3,5-dicarbonitrile
• CAS: 96461-43-7
• 化学式: C₁₃H₉N₅
• 分子量: 235.248
• InChiKey: SXSZXZRHAGWABV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,6-diamino-4-phenylpyridine-3,5-dicarbonitrile 在 palladium on activated charcoal 盐酸 、 氢氧化钾 、 氢气 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 3.0h， 生成 5-phenyl-2,8-bis(2-pyridinyl)-1,9,10-anthyridine
  参考文献：
  名称：

  Synthesis of heterocyclic compounds containing three contiguous hydrogen bonding sites in all possible arrangements

  摘要：

  The synthesis of compounds containing three contiguous hydrogen bond sites is reported. There are six ways of arranging three adjacent hydrogen bond donor (D) and acceptor (A) sites. General synthetic routes to heterocyclic compounds with each arrangement is reported.

  DOI：

  10.1016/0040-4020(94)00922-h
• 作为产物：
  描述：

  原苯甲酸三甲酯 在 吡啶 、 盐酸 、 ammonium hydroxide 作用下， 以 丙酮 为溶剂， 反应 20.0h， 生成 2,6-diamino-4-phenylpyridine-3,5-dicarbonitrile
  参考文献：
  名称：

  Synthesis of heterocyclic compounds containing three contiguous hydrogen bonding sites in all possible arrangements

  摘要：

  The synthesis of compounds containing three contiguous hydrogen bond sites is reported. There are six ways of arranging three adjacent hydrogen bond donor (D) and acceptor (A) sites. General synthetic routes to heterocyclic compounds with each arrangement is reported.

  DOI：

  10.1016/0040-4020(94)00922-h

文献信息

• Multicomponent Reactions, Solvent-Free Synthesis of 2-Amino-4-aryl-6-substituted Pyridine-3,5-dicarbonitrile Derivatives, and Corrosion Inhibitors Evaluation
  作者：Naglaa F. H. Mahmoud、Ahmed El-Sewedy

  DOI：10.1155/2018/7958739

  日期：2018.12.19

  multicomponent condensation reactions of different aromatic aldehydes with malononitrile and different primary amines, using different molecular ratios and different reaction conditions to achieve considerable product yields. Moreover, we succeed, for the first time to develop a new method to synthesize the aforementioned under the fusion condition without using solvent and catalysts. With this method, a wide

  通过不同的芳香醛与丙二腈和不同的伯胺，使用不同的分子比和不同的反应条件，通过一锅多组分缩合反应合成了许多2-氨基-4-芳基-6-取代的吡啶-3,5-二甲腈衍生物以达到可观的产品产量。此外，我们首次成功开发了一种在融合条件下不使用溶剂和催化剂合成上述物质的新方法。使用该方法，合成了多种新型 2-氨基-3,5-二氰基-4-芳基-6-取代氨基吡啶衍生物，收率高且具有官能团的基板底物。发现合成的吡啶衍生物具有缓蚀效率，缓蚀率随着衍生物浓度的增加而增加。
• Convenient, multicomponent, one-pot synthesis of highly substituted pyridines under solvent-free conditions
  作者：Akbar Mobinikhaledi、Sajad Asadbegi、Mohammad Ali Bodaghifard

  DOI：10.1080/00397911.2016.1218516

  日期：2016.10.1

  ABSTRACT Highly substituted pyridine derivatives have been accessed through an efficient, one-pot, multicomponent reaction of aldehydes, malononitrile, and ammonium acetate in the presence of triethylamine as a catalyst under solvent-free conditions. This procedure affords the desired products in high purity and has advantages such as short reaction time, excellent yields, and simple workup procedure

  摘要 在无溶剂条件下，在三乙胺作为催化剂的情况下，通过醛、丙二腈和醋酸铵的高效、一锅多组分反应，已获得高度取代的吡啶衍生物。该程序提供了高纯度的所需产品，并具有反应时间短、收率高和后处理程序简单等优点。该程序以中等至高产率提供所需产物，并具有反应时间短和后处理程序简单等优点。图形概要
• Medicine comprising dicyanopyridine derivative
  申请人：——

  公开号：US20030232860A1

  公开（公告）日：2003-12-18

  Compounds having a high conductance-type of calcium-activated K channel opening effect and a smooth muscle relaxant effect for bladder based on the K-channel opening effect, which can be used in treating pollakiuria and urinary incontinence, are provided. 3,5-Dicyanopyridine derivatives or their salts.

  基于K通道开放效应的高导电型钙激活K通道开放效应和平滑肌松弛剂效应的化合物，可用于治疗尿频和尿失禁。提供3,5-二氰基吡啶衍生物或其盐。
• MEDICINE COMPRISING DICYANOPYRIDINE DERIVATIVE
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1302463A1

  公开（公告）日：2003-04-16

  Compounds having a high conductance-type of calcium-activated K channel opening effect and a smooth muscle relaxant effect for bladder based on the K-channel opening effect, which can be used in treating pollakiuria and urinary incontinence, are provided. 3,5-Dicyanopyridine derivatives or their salts.

  基于K通道开放效应具有高导电型钙激活K通道开放效应和平滑肌松弛作用的化合物，可用于治疗尿频和尿失禁。提供3,5-二氰基吡啶衍生物或其盐。
• Synthesis, optical properties of multi donor–acceptor substituted AIE pyridine derivatives dyes and application for Au 3+ detection in aqueous solution
  作者：Junjuan Yang、Jiarong Li、Pengfei Hao、Fadong Qiu、Mingxing Liu、Qi Zhang、Daxin Shi

  DOI：10.1016/j.dyepig.2015.01.005

  日期：2015.5

  A series of multi donor–acceptor substituted pyridine derivative dyes were synthesed by three-component catalyst-free domino reaction in methanol aqueous at room temperature. The pyridine derivative dyes with thermally stable fluorescence exhibit aggregation-induced emission (AIE) in both aqueous solution and solid state due to the restricted intramolecular rotation as well. Furthermore, the family

  在室温下于甲醇水溶液中，通过三组分无催化剂多米诺反应，合成了一系列多供体-受体取代的吡啶衍生物染料。由于分子内旋转也受到限制，具有热稳定荧光的吡啶衍生物染料在水溶液和固态下均表现出聚集诱导的发射（AIE）。此外，分子染料家族几乎显示了从蓝色到绿色再到橙色的所有颜色发射器。此外，通过“关闭”检测水溶液中的Au 3+具有简单的合成方法，高选择性和灵敏度，证明了染料在重金属和过渡金属离子种类检测应用中的重要性。