甲氧基万寿菊素 | 5188-73-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 甲氧基万寿菊素
• 英文名称: axillarin
• 英文别名: 5,7,3′,4′-tetrahydroxy-3,6-dimethoxyflavone；3',4',5,7-tetrahydroxy-3,6-dimethoxyflavone；3,6-dimethoxy-5,7,3',4'-tetrahydroxyflavone；5,7,3',4'-tetrahydroxy-3,6-dimethoxyflavone；quercetagetin 3,6-dimethyl ether；quercetagetin-3,6-dimethyl ether；2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,6-dimethoxychromen-4-one
• CAS: 5188-73-8
• 化学式: C₁₇H₁₄O₈
• 分子量: 346.293
• InChiKey: KIGVXRGRNLQNNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

安全信息

• 海关编码：
  2914509090
• 储存条件：
  室温

制备方法与用途

axillarin 是一种天然黄酮类化合物，具有抗糖化和抗氧化的作用。

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 甲氧基万寿菊素 生成 2-(3,4-二甲氧基苯基)-3,5,6,7-四甲氧基-4H-苯并吡喃-4-酮
  参考文献：
  名称：

  Flavonol glycosides in leaves of Spinacia oleracea

  摘要：

  DOI：

  10.1016/s0031-9422(00)94534-5
• 作为产物：
  描述：

  spinatoside 在 盐酸 作用下， 生成 甲氧基万寿菊素 、 D-吡喃葡萄糖醛酸
  参考文献：
  名称：

  Flavonol glycosides in leaves of Spinacia oleracea

  摘要：

  DOI：

  10.1016/s0031-9422(00)94534-5

文献信息

• Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
  申请人：Scaramuzzino, Giovanni

  公开号：EP1336602A1

  公开（公告）日：2003-08-20

  New pharmaceutical compounds of general formula (I): F-(X)q where q is an integer from 1 to 5, preferably 1; -F is chosen among drugs described in the text, -X is chosen among 4 groups -M, -T, -V and -Y as described in the text. The compounds of general formula (I) are nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without hypotensive side effects and for this reason they are useful for the preparation of medicines for prevention and treatment of inflammatory, ischemic, degenerative and proliferative diseases of musculoskeletal, tegumental, respiratory, gastrointestinal, genito-urinary and central nervous systems.

  通式（I）的新药物化合物：F-（X）q，其中q是1到5的整数，最好是1；-F是在文本中描述的药物中选择的，-X是在文本中描述的4个组-M，-T，-V和-Y中选择的。通式（I）的化合物是硝酸盐前药，可以在体内以受控和选择性的方式释放一氧化氮，而不会产生降压副作用，因此它们非常适用于制备用于预防和治疗肌肉骨骼，皮肤，呼吸，消化，泌尿和中枢神经系统的炎症，缺血，退行性和增生性疾病的药物。
• [EN] POLYPHENOL-PEPTIDE CONJUGATES FOR NUCLEAR-TARGETED DELIVERY<br/>[FR] CONJUGUÉS POLYPHÉNOL-PEPTIDE POUR L'ADMINISTRATION CIBLANT LE NOYAU
  申请人：UNIV WIEN

  公开号：WO2020136240A1

  公开（公告）日：2020-07-02

  The present invention relates to a polyphenol-peptide conjugate composed of: (i) a peptide comprising the amino acid sequence Arg-Arg-X1-Leu, wherein X1 refers to one or two hydrophobic amino acids selected independently from lie, Leu, Val, Phe, Trp, and Met; (ii) at least one polyphenol which is covalently bound to the peptide; and (iii) optionally at least one cargo which, if present, is covalently bound to the peptide. The polyphenol-peptide conjugate can be encapsulated with silica. The invention thus also provides silica particles comprising the polyphenol-peptide conjugate encapsulated by a silica shell. The silica particles allow the efficient cellular uptake and targeted delivery of the polyphenol-peptide conjugate into the cell nucleus, and can therefore advantageously be used for nuclear-targeted gene or drug delivery.

  本发明涉及一种由以下组成的多酚-肽共轭物：（i）包括氨基酸序列Arg-Arg-X1-Leu的肽，其中X1是从lie、Leu、Val、Phe、Trp和Met中独立选择的一个或两个疏水性氨基酸；（ii）至少一种共价结合到肽上的多酚；以及（iii）可选地，至少一种共价结合到肽上的载荷。多酚-肽共轭物可以被硅化物封装。因此，本发明还提供了由硅壳封装的多酚-肽共轭物的硅颗粒。硅颗粒能够有效地被细胞摄取并定向传递到细胞核中，因此可以有利地用于核靶向基因或药物传递。
• REMEDY FOR SPINAL CANAL STENOSIS
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1609480A1

  公开（公告）日：2005-12-28

  A remedy for spinal canal stenosis which comprises a combination of a compound having EP2 agonism with a compound having EP3 agonism. A drug comprising a combination of a compound having EP2 agonism with a compound having EP3 agonism shows an efficacy in a rat gait disorder model induced by compression of cauda equina. Namely, it is efficacious against spinal canal stenosis to use a combination of a compound having EP2 agonism with a compound having EP3 agonism or a compound having both EP2 agonism and EP3 agonism.

  一种治疗椎管狭窄症的药物，由一种具有 EP2 激动作用的化合物和一种具有 EP3 激动作用的化合物组合而成。一种由具有 EP2 激动作用的化合物和具有 EP3 激动作用的化合物组合而成的药物在马尾受压诱发的大鼠步态障碍模型中显示出疗效。也就是说，将具有 EP2 激动作用的化合物与具有 EP3 激动作用的化合物或同时具有 EP2 激动作用和 EP3 激动作用的化合物组合使用，对椎管狭窄症有疗效。
• NOVEL AIR PURIFICATION COMPOSITION HAVING ANTIVIRAL AND BACTERICIDAL FUNCTIONS
  申请人：Wang, Jingning

  公开号：EP3650105A1

  公开（公告）日：2020-05-13

  Disclosed is a novel air purification composition with antiviral and bactericidal functions, the composition at least comprising the following components in percentage by weight: 0.3%-1% of a black poplar essential oil, 0.1%-1% of a tea tree essential oil, 0.1%-0.5% of a Cupressus funebris essential oil, 0.1%-1% of an Artemisia apiacea essential oil, 0.1%-10% of a Sophora flavescens extract, 0. 1%-5% of a ginger extract, 5%-30% of a Cupressus funebris hydrolate, 0.5%-1% of a hyperbranched amino polymer, 0.5%-5% of a surfactant, and the balance being water.

  本发明公开了一种具有抗病毒和杀菌功能的新型空气净化组合物，该组合物按重量百分比至少包括以下成分：0.3%-1%的黑杨精油、0.1%-1%的茶树精油、0.1%-0.1%-5%的生姜提取物，5%-30%的冲天香水合物，0.5%-1%的超支化氨基酸聚合物，0.5%-5%的表面活性剂，余量为水。
• POLYPHENOL-PEPTIDE CONJUGATES FOR NUCLEAR-TARGETED DELIVERY
  申请人：Universität Wien

  公开号：EP3673920A1

  公开（公告）日：2020-07-01

  The present invention relates to a polyphenol-peptide conjugate composed of: (i) a peptide comprising the amino acid sequence Arg-Arg-X1-Leu, wherein X1 refers to one or two hydrophobic amino acids selected independently from lie, Leu, Val, Phe, Trp, and Met; (ii) at least one polyphenol which is covalently bound to the peptide; and (iii) optionally at least one cargo which, if present, is covalently bound to the peptide. The polyphenol-peptide conjugate can be encapsulated with silica. The invention thus also provides silica particles comprising the polyphenol-peptide conjugate encapsulated by a silica shell. The silica particles allow the efficient cellular uptake and targeted delivery of the polyphenol-peptide conjugate into the cell nucleus, and can therefore advantageously be used for nuclear-targeted gene or drug delivery.

  本发明涉及一种多酚-多肽共轭物，其组成包括：(i) 包含 Arg-Arg-X1-Leu 氨基酸序列的多肽，其中 X1 指从 lie、Leu、Val、Phe、Trp 和 Met 中独立选出的一个或两个疏水氨基酸；(ii) 至少一种与多肽共价结合的多酚；(iii) 可选的至少一种与多肽共价结合的货物（如果存在）。多酚-肽共轭物可以用二氧化硅封装。因此，本发明还提供了由二氧化硅外壳封装的多酚肽共轭物组成的二氧化硅颗粒。这种二氧化硅颗粒可使多酚多肽共轭物有效地被细胞吸收并定向递送到细胞核中，因此可用于核靶向基因或药物递送。