(9H-fluoren-9-yl)methyl (4-formylbenzyl)carbamate | 475160-90-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (9H-fluoren-9-yl)methyl (4-formylbenzyl)carbamate
• 英文别名: 9H-Fluoren-9-ylmethyl 4-formylbenzylcarbamate；9H-fluoren-9-ylmethyl N-[(4-formylphenyl)methyl]carbamate
• CAS: 475160-90-8
• 化学式: C₂₃H₁₉NO₃
• 分子量: 357.409
• InChiKey: YKURYGCYBKKVRF-UHFFFAOYSA-N

物化性质

• 沸点：
  591.3±38.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (9H-fluoren-9-yl)methyl (4-formylbenzyl)carbamate 、 原甲酸三甲酯 在 对甲苯磺酸 作用下， 生成 (4-dimethoxymethylbenzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
  参考文献：
  名称：

  Synthesis of 7200 Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors Trichostatin and Trapoxin

  摘要：

  [GRAPHICS]Seventy-two hundred potential inhibitors of the histone deacetylase (HDAC) enzyme family, based on a 1,3-dioxane diversity structure, were synthesized on polystyrene macrobeads. The compounds were arrayed for biological assays in a "one bead-one stock solution" format. Metal-chelating functional groups were used to direct the 1,3-dioxanes to HDAC enzymes, which are zinc hydrolases. Representative structures from this library were tested for inhibitory activity and the 1,3-dioxane structure was shown to be compatible with HDAC inhibition.

  DOI：

  10.1021/ol016915f
• 作为产物：
  描述：

  4-氨甲基苯甲酸 在 草酰氯 、 氯甲酸乙酯 、 sodium carbonate 、 二甲基亚砜 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 15.5h， 生成 (9H-fluoren-9-yl)methyl (4-formylbenzyl)carbamate
  参考文献：
  名称：

  Synthesis of 7200 Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors Trichostatin and Trapoxin

  摘要：

  [GRAPHICS]Seventy-two hundred potential inhibitors of the histone deacetylase (HDAC) enzyme family, based on a 1,3-dioxane diversity structure, were synthesized on polystyrene macrobeads. The compounds were arrayed for biological assays in a "one bead-one stock solution" format. Metal-chelating functional groups were used to direct the 1,3-dioxanes to HDAC enzymes, which are zinc hydrolases. Representative structures from this library were tested for inhibitory activity and the 1,3-dioxane structure was shown to be compatible with HDAC inhibition.

  DOI：

  10.1021/ol016915f

文献信息

• Selective reduction of carboxylic acids to aldehydes with hydrosilane via photoredox catalysis
  作者：Muliang Zhang、Nan Li、Xingyu Tao、Rehanguli Ruzi、Shouyun Yu、Chengjian Zhu

  DOI：10.1039/c7cc05570f

  日期：——

  The direct reduction of carboxylic acids to aldehydes with hydrosilane was achieved through visible light photoredox catalysis. The combination of both single electron transfer and hydrogen atom transfer steps offers a novel and convenient approach to selective reduction of carboxylic acids to aldehydes. The method also features mild conditions, high yields, broad substrate scope, and good functional

  通过可见光光氧化还原催化可将羧酸与氢硅烷直接还原为醛。单电子转移步骤和氢原子转移步骤的结合提供了一种新颖且方便的方法，用于将羧酸选择性还原为醛。该方法还具有温和的条件，高收率，广泛的底物范围和良好的官能团耐受性，例如炔烃基，酯基，酮基，酰胺基和胺基。
• Dioxanes and uses thereof
  申请人：——

  公开号：US20040072849A1

  公开（公告）日：2004-04-15

  In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): 1 and pharmaceutically acceptable derivatives thereof, wherein R 1 , R 2 , R 3 , n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.

  鉴于需要开发新型治疗剂和有效的合成方法，本发明提供了一般式(I)的新化合物： 1 及其药学上可接受的衍生物，其中R 1 ，R 2 ，R 3 ，n，X和Y如本文所定义。本发明还提供了包含一种式(I)化合物和药学上可接受的载体的药物组合物。本发明还提供了能够抑制组蛋白去乙酰化酶活性的化合物以及治疗由组蛋白去乙酰化酶活性调节的疾病的方法（例如，癌症和原虫感染），包括向需要的受体施用一种式(I)化合物的治疗有效量。本发明还提供了调节Ure2p下游葡萄糖敏感基因子集的方法。本发明还提供了制备本发明化合物的方法。
• US7244853B2
  申请人：——

  公开号：US7244853B2

  公开（公告）日：2007-07-17
• US8178579B2
  申请人：——

  公开号：US8178579B2

  公开（公告）日：2012-05-15
• Synthesis of 7200 Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors Trichostatin and Trapoxin
  作者：Scott M. Sternson、Jason C. Wong、Christina M. Grozinger、Stuart L. Schreiber

  DOI：10.1021/ol016915f

  日期：2001.12.1

  [GRAPHICS]Seventy-two hundred potential inhibitors of the histone deacetylase (HDAC) enzyme family, based on a 1,3-dioxane diversity structure, were synthesized on polystyrene macrobeads. The compounds were arrayed for biological assays in a "one bead-one stock solution" format. Metal-chelating functional groups were used to direct the 1,3-dioxanes to HDAC enzymes, which are zinc hydrolases. Representative structures from this library were tested for inhibitory activity and the 1,3-dioxane structure was shown to be compatible with HDAC inhibition.