4-benzyloxy-4-methylpent-2-yn-1-yl methanesulfonate | 1610010-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-benzyloxy-4-methylpent-2-yn-1-yl methanesulfonate
• 英文别名: (4-Methyl-4-phenylmethoxypent-2-ynyl) methanesulfonate
• CAS: 1610010-39-3
• 化学式: C₁₄H₁₈O₄S
• 分子量: 282.361
• InChiKey: IGHKRJDIJUXFPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-benzyloxy-4-methylpent-2-yn-1-yl methanesulfonate 在 potassium tert-butylate 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 16.0h， 生成 3-(4-(benzyloxy)-4-methylpenta-1,2-dien-1-yl)oxazolidin-2-one
  参考文献：
  名称：

  Nickel(0)-Promoted Carboxylation of Allenamides with Carbon Dioxide via a Nickelalactone Intermediate

  摘要：

  Nickel(0)-promoted carboxylation of N-allenylamides (allenamides) with carbon dioxide proceeded via a nickelalactone intermediate to give beta-amino acid derivatives. It was also found that the regioselectivity at the oxidative addition stage was strongly affected by the substituents on the allene part.

  DOI：

  10.1055/s-0033-1340628
• 作为产物：
  描述：

  2-甲基-3-丁炔-2-醇 在 正丁基锂 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 24.5h， 生成 4-benzyloxy-4-methylpent-2-yn-1-yl methanesulfonate
  参考文献：
  名称：

  Nickel(0)-Promoted Carboxylation of Allenamides with Carbon Dioxide via a Nickelalactone Intermediate

  摘要：

  Nickel(0)-promoted carboxylation of N-allenylamides (allenamides) with carbon dioxide proceeded via a nickelalactone intermediate to give beta-amino acid derivatives. It was also found that the regioselectivity at the oxidative addition stage was strongly affected by the substituents on the allene part.

  DOI：

  10.1055/s-0033-1340628

文献信息

• [EN] METHODS AND INTERMEDIATES FOR THE PREPARATION OF OMACETAXINE AND CEPHALOTAXINE DERIVATIVES THEREOF<br/>[FR] MÉTHODES ET INTERMÉDIAIRES POUR LA PRÉPARATION D'OMACÉTAXINE ET DE DÉRIVÉS DE CÉPHALOTAXINE ASSOCIÉS
  申请人：ALBANY MOLECULAR RES INC

  公开号：WO2016182850A1

  公开（公告）日：2016-11-17

  The present invention relates to methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. The resulting products are useful in the treatment of proliferative diseases and infectious diseases.

  本发明涉及用于制备omacetaxine和cephalotaxine衍生物的方法和中间体。所得产品在治疗增殖性疾病和传染性疾病方面具有用途。
• Methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof
  申请人：ALBANY MOLECULAR RESEARCH, INC.

  公开号：US10597401B2

  公开（公告）日：2020-03-24

  The present invention relates to methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. The resulting products are useful in the treatment of proliferative diseases and infectious diseases.

  本发明涉及奥美他辛及其头孢他辛衍生物的制备方法和中间体。所得产品可用于增殖性疾病和传染性疾病的治疗。
• METHODS AND INTERMEDIATES FOR THE PREPARATION OF OMACETAXINE AND CEPHALOTAXINE DERIVATIVES THEREOF
  申请人：ALBANY MOLECULAR RESEARCH, INC.

  公开号：US20180134724A1

  公开（公告）日：2018-05-17

  The present invention relates to methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. The resulting products are useful in the treatment of proliferative diseases and infectious diseases.