2-benzyloxy-4-methyl-benzoylchloride | 433712-96-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzyloxy-4-methyl-benzoylchloride
• 英文别名: Benzyloxy-4-methylbenzoyl chloride；4-methyl-2-phenylmethoxybenzoyl chloride
• CAS: 433712-96-0
• 化学式: C₁₅H₁₃ClO₂
• 分子量: 260.72
• InChiKey: VRWFRRNLTDKXRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-benzyloxy-4-methyl-benzoylchloride 在 palladium on activated charcoal 、 四丁基溴化铵 氢氧化钾 、 sodium tetrahydroborate 、 硫酸 、 三(3,6-二氧杂庚基)胺 、 氢气 、 三溴化磷 、 copper(l) chloride 作用下， 以 1,4-二氧六环 、 甲醇 、 乙醇 、 二氯甲烷 、 二乙二醇二甲醚 、 水 、 苯 为溶剂， 反应 23.42h， 生成 (1,5-Dimethyl-9-oxo-9H-xanthen-4-yl)-acetic acid
  参考文献：
  名称：

  潜在的抗肿瘤药。61.二取代的9-氧代-9H-氧杂蒽-4-乙酸中体内结肠38活性的结构-活性关系。

  摘要：

  带有小的，亲脂性的5个取代基的9-氧代9H-氧杂蒽-4-乙酸（XAA）的类似物是迄今已报道的最强剂量化合物，具有引起小鼠植入的结肠38肿瘤出血性坏死的能力。为了进一步扩展这类化合物之间的构效关系，已经制备并评估了一系列在不同位置带有两个小的亲脂基团的XAA衍生物。特别是5，6-二取代的化合物始终显示出高水平的剂量效力和活性，这表明这是取代的9-氧代-9H-氧杂蒽-4-乙酸中的最佳构型。5,6-二甲基和5-甲基-6-甲氧基是最有效的类似物，

  DOI：

  10.1021/jm00105a034
• 作为产物：
  描述：

  4-甲基水杨酸甲酯 在 sodium hydroxide 、 草酰氯 、 potassium carbonate 、 N,N-二异丙基乙胺 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 2-benzyloxy-4-methyl-benzoylchloride
  参考文献：
  名称：

  Solid-Phase synthesis of new saphenamycin analogues with antimicrobial activity

  摘要：

  An array of 12 new saphenamycin analogues modified at the benzoate moiety was synthesized on solid support. Synthesis commenced with a chemoselective anchoring of saphenic acid through the carboxyl group to a 2-chlorotrityl functionalized polystyrene resin. The secondary alcohol was acylated in parallel with a series of differently substituted benzoic acid derivatives. Treatment with TFA-CH2Cl2 (5:995) released the expected saphenamycin analogues into solution. These new analogues were purified, characterized and screened for antimicrobial activity against Bacillus subtilis and Proteus mirabilis. Eight analogues exhibited MIC values against B. subtilis ranging from 0.07 to 3.93 mug/mL, comparable to the activities of previously reported saphenamycin analogues. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00692-8

文献信息

• BICYCLIC PYRAZOLE AND ISOXAZOLE DERIVATIVES AS ANTITUMOR AND ANTINEURODEGENERATIVE AGENTS
  申请人：Mantegani Sergio

  公开号：US20110294790A1

  公开（公告）日：2011-12-01

  Bicyclic pyrazole and isoxazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases mediated by HSP90 protein, like cancer and neurodegenerative disorders.

  本发明揭示了式（I）的双环吡唑和异噁唑衍生物及其药学上可接受的盐，其定义详见规范，以及其制备方法和包含它们的制药组合物；本发明中的化合物可能在治疗由HSP90蛋白介导的疾病，如癌症和神经退行性疾病中有用。
• Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo
  作者：Gordon W. Rewcastle、Graham J. Atwell、Bruce C. Baguley、Stephen B. Calveley、William A. Denny

  DOI：10.1021/jm00124a012

  日期：1989.4

  In a search for compounds related to flavoneacetic acid with activity against solid tumors, a series of methyl-, methoxy-, chloro-, nitro-, and hydroxy-substituted xanthenone-4-acetic acids have been synthesized and evaluated against subcutaneously implanted colon adenocarcinoma 38 in vivo, using a short-term histology assay as a primary screening system. A major goal of this work was to identify compounds with similar profiles of activity to that of flavoneacetic acid but of higher potency. The level of activity of the compounds appeared to depend more on the nature of the substituent than its positioning, in the order Cl greater than Me, OMe greater than NO2, OH. However, the potency of the compounds was related much more to the position rather than the nature of the substitution, with 5-substituted compounds being clearly the most dose potent. 5-Methylxanthenone-4-acetic acid has a similar level of activity to that of flavoneacetic acid in the test systems employed but is more than 7-fold as dose potent.
• REWCASTLE, GORDON W.;ATWELL, GRAHAM J.;BAGULEY, BRUCE C.;CALVELEY, STEPHE+, J. MED. CHEM., 32,(1989) N, C. 793-799
  作者：REWCASTLE, GORDON W.、ATWELL, GRAHAM J.、BAGULEY, BRUCE C.、CALVELEY, STEPHE+

  DOI：——

  日期：——
• US8309578B2
  申请人：——

  公开号：US8309578B2

  公开（公告）日：2012-11-13
• Solid-Phase synthesis of new saphenamycin analogues with antimicrobial activity
  作者：Jane B Laursen、Peter C de Visser、Henrik K Nielsen、Knud J Jensen、John Nielsen

  DOI：10.1016/s0960-894x(01)00692-8

  日期：2002.1

  An array of 12 new saphenamycin analogues modified at the benzoate moiety was synthesized on solid support. Synthesis commenced with a chemoselective anchoring of saphenic acid through the carboxyl group to a 2-chlorotrityl functionalized polystyrene resin. The secondary alcohol was acylated in parallel with a series of differently substituted benzoic acid derivatives. Treatment with TFA-CH2Cl2 (5:995) released the expected saphenamycin analogues into solution. These new analogues were purified, characterized and screened for antimicrobial activity against Bacillus subtilis and Proteus mirabilis. Eight analogues exhibited MIC values against B. subtilis ranging from 0.07 to 3.93 mug/mL, comparable to the activities of previously reported saphenamycin analogues. (C) 2002 Elsevier Science Ltd. All rights reserved.