4b,9b-dihydroxy-7-methyl-4bH-benzo[d]indeno[1,2-b]furan-10(9bH)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 4b,9b-dihydroxy-7-methyl-4bH-benzo[d]indeno[1,2-b]furan-10(9bH)-one
• 英文别名: 4b,9b-Dihydroxy-7-methyl-4bH-benzo[d]indeno[1,2-b]furan-10(9bH)-one；4b,9b-dihydroxy-7-methylindeno[1,2-b][1]benzofuran-10-one
• 化学式: C₁₆H₁₂O₄
• 分子量: 268.269
• InChiKey: FHAGIQCIPWCQRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4b,9b-dihydroxy-7-methyl-4bH-benzo[d]indeno[1,2-b]furan-10(9bH)-one 在 ammonium acetate 、 溶剂黄146 作用下， 反应 1.0h， 生成
  参考文献：
  名称：

  Facile synthesis of 3H,3′H-spiro[benzofuran-2,1′-isoindole]-3,3′-diones using monobromomalononitrile (MBM) as an efficient organo-brominating agent

  摘要：

  An efficient methodology for the synthesis of 3H,3'H-spiro[benzofuran-2,1'-isoindole]-3,3'-diones has been developed where monobromomalononitrile (MBM) has been employed as a non-hazardous brominating agent under ambient reaction condition. The intrinsic advantages of the methodology are the utilization of simple and easily available starting materials and non-toxic reagents, operational simplicity, and good yields of the products with high atom-economy. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.04.027
• 作为产物：
  描述：

  水合茚三酮 、 间甲酚 在 溶剂黄146 作用下， 生成 4b,9b-dihydroxy-7-methyl-4bH-benzo[d]indeno[1,2-b]furan-10(9bH)-one
  参考文献：
  名称：

  一般支链聚合物的计算线性流变学

  摘要：

  我们提出了一种预测支化聚合物线性流变学的通用算法。虽然该方法很大程度上借鉴了对缠结聚合物熔体中松弛过程的现有理论理解，但开发了许多新概念来处理包括分支对分支结构在内的各种聚合物结构。我们使用来自模型聚合物架构的实验示例验证算法，以修复模型的参数。我们使用实验确定的参数来生成支化茂金属催化聚乙烯树脂的数值集合。我们算法的应用显示了系统中支链对支链的重要性，并预测了线性流变学，并在广泛的支化密度和分子量范围内具有良好的定量一致性。

  DOI：

  10.1122/1.2167487

文献信息

• INDANONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS OR OPTICAL ISOMERS THEREOF, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING VIRAL DISEASES
  申请人：Jung Young Sik

  公开号：US20140114068A1

  公开（公告）日：2014-04-24

  Disclosed are novel indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The indanone derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

  揭示了新颖的茚酮衍生物，其药用盐或对映体，以及其制备方法和作为活性成分的用于预防或治疗病毒性疾病的药物组合物。这些茚酮衍生物对包括柯萨奇病毒、肠道病毒、回声病毒、脊髓灰质炎病毒和鼻病毒在内的小RNA病毒具有出色的抑制活性，并且具有低细胞毒性，因此它们可用作预防或治疗包括小儿麻痹症、瘫痪、急性出血性结膜炎、病毒性脑膜炎、手足口病、水疱病、甲型肝炎、肌炎、心肌炎、胰腺炎、糖尿病、流行性肌痛、脑炎、流感、手足口病、哮喘、慢性阻塞性肺病、肺炎、鼻窦炎或中耳炎等病毒性疾病的药物组合物的活性成分。
• Facile Chemoselective synthesis of 2-(2-(Methoxycarbonyl)-3-oxo-2,3-dihydrobenzofuran-2-yl)benzoic acids and 3<i>H</i>,3’<i>H</i>-Spiro[benzofuran-2,1′-isobenzofuran]-3,3′-dione derivatives
  作者：Neda Firoozi、Zohreh Roshan、Mohammad Reza Mohammadizadeh

  DOI：10.1002/aoc.3963

  日期：2018.1

  derivatives of 4b,9b–dihydroxyindeno[1,2‐b]benzofuran‐10‐one have been investigated in detail using lead(IV) acetate in acetic acid under reflux conditions and periodic acid in aqueous ethanol at room temperature. We realized that during the first 5–15 minutes of the oxidation reactions in lead(IV) acetate/acetic acid system, 3H,3’H‐spiro[benzofuran‐2,1′‐isobenzofuran]‐3,3′‐dione derivatives have been

  在回流条件下，使用乙酸铅（IV）在乙酸中，在室温下于乙醇水溶液中，对4b，9b-二羟基茚并[1,2- b ]苯并呋喃-10-one的某些衍生物的氧化进行了详细研究。我们认识到，在第一5-15分钟铅（IV）乙酸盐/乙酸系统，3氧化反应的ħ，3' ħ -螺[苯并呋喃-2,1'-异苯并呋喃] -3,3'-二酮衍生物是选择性化学合成的，而如果将反应混合物再搅拌3小时，则主要产物将是2-（2-（甲氧羰基）-3-氧代-2,3-二氢苯并呋喃-2-基）苯甲酸。此外，高碘酸在室温下氧化4b，9b-二羟基茚并[1,2 - b ]苯并呋喃-10-酮（H 5IO 6），导致3的形成ħ，3' ħ以良好至优异的产率-螺[苯并呋喃-2,1'-异苯并呋喃] -3,3'-二酮衍生物。
• 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT
  申请人：Korea Research Institute of Chemical Technology

  公开号：EP3611158A1

  公开（公告）日：2020-02-19

  Disclosed are 1,3-Dioxoindene derivatives of Formula 1, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

  本发明公开了式 1 的 1,3-二氧代茚衍生物、其药学上可接受的盐或对映体、其制备方法以及用于预防或治疗病毒性疾病的药物组合物，其中包含相同的活性成分。1,3-二氧代茚满衍生物对包括柯萨奇病毒、肠道病毒、回声病毒、脊髓灰质炎病毒和鼻病毒在内的短小病毒具有极佳的抑制活性，同时还表现出较低的细胞毒性，因此可作为药物组合物的活性成分，用于预防或治疗包括脊髓灰质炎在内的病毒性疾病、麻痹、急性出血性结膜炎、病毒性脑膜炎、手足口病、水泡病、甲型肝炎、肌炎、心肌炎、胰腺炎、糖尿病、流行性肌痛、脑炎、流感、疱疹、口蹄疫、哮喘、慢性阻塞性肺病、肺炎、鼻窦炎或中耳炎。
• 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT
  申请人：Korea Research Institute of Chemical Technology

  公开号：EP2722322B8

  公开（公告）日：2020-03-11
• Efficient synthesis of 3 H ,3′ H -spiro[benzofuran-2,1′-isobenzofuran]-3,3′-dione as novel skeletons specifically for influenza virus type B inhibition
  作者：Yashwardhan Malpani、Raghavendra Achary、So Yeon Kim、Hee Chun Jeong、Pilho Kim、Soo Bong Han、Meehyein Kim、Chong-Kyo Lee、Jae Nyoung Kim、Young-Sik Jung

  DOI：10.1016/j.ejmech.2013.01.015

  日期：2013.4

  An efficient and novel two step synthetic procedure to prepare various substituted 3H,3'H-spiro[benzofuran-2,1'-isobenzofuran]-3,3'-diones A, was established from very simple and easily available starting materials. The developed method is a robust and general approach for the synthesis of these structures. The prepared compounds were tested against influenza virus type A viz., A/Taiwan/1/86 (H1N1), A/Hong Kong/8/68 (H3N2) and type B viz., B/Panama/45/90, B/Taiwan/2/62, B/Lee/40, B/Brisbane/60/2008. Among 31 compounds tested, some of them showed good activity (selective index values >10) against these influenza viruses preferentially for type B. The most active compound 3b showed activity in 3.0-16.1 mu M range with a selectivity index value between 30 and 166 against these type B viruses, in which it was comparable to the antiviral agent favipiravir. Also, 3b is found to be inactive against other enveloped viruses (viz., HIV and HSV) showing its specificity for influenza viruses. (C) 2013 Elsevier Masson SAS. All rights reserved.