cis-[Pt((15)NH3)2(H2O)2](ClO4)2 | 20115-64-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物
• 英文名称: cis-[Pt((15)NH3)2(H2O)2](ClO4)2
• CAS: 20115-64-4
• 化学式: 2ClO₄*H₁₀N₂O₂Pt
• 分子量: 466.059
• InChiKey: RMZILXCZFGMJRC-CEQQFHIZSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  sodium dihydrogenphosphate 、 cis-[Pt((15)NH3)2(H2O)2](ClO4)2 在 高氯酸 作用下， 以 水 为溶剂， 生成 cis-Pt(NH3)2(OPO3H2)(H2O)(1+)
  参考文献：
  名称：

  Reactions of platinum(II) aqua complexes. 1. Multinuclear (platinum-195, nitrogen-15, and phosphorus-31) NMR study of reactions between the cis-diamminediaquaplatinum(II) cation and the oxygen-donor ligands hydroxide, perchlorate, nitrate, sulfate, phosphate, and acetate

  摘要：

  DOI：

  10.1021/ic00190a016
• 作为产物：
  描述：

  cis-Pt((15)NH3)2Cl2 、 sodium perchlorate 、 水 在 silver nitrate 作用下， 以 N,N-二甲基甲酰胺-d7 、 水 、 重水 为溶剂， 生成 cis-[Pt((15)NH3)2(H2O)2](ClO4)2
  参考文献：
  名称：

  Rates of Platination of AG and GA Containing Double-Stranded Oligonucleotides:  Insights into Why Cisplatin Binds to GG and AG but Not GA Sequences in DNA

  摘要：

  The reactions of the self-complementary 14-base-pair duplexes 5'-d(AATTAGTACTAATT)-3' (-AG-) and 5'-d(AATTGATATCAATT)-3' (-GA-) with N-15-cisplatin, (cis-[PtCl2((NH3)-N-15)(2)]) (pH 6.0, T = 298 K) and cis-[Pt((NH3)-N-15)(2)(OH2)(2)](2+). (pH 4.9, T = 288 K), have been investigated using [H-1,N-15] HSQC 2D NMR spectroscopy. Reactions involving cisplatin progress via the hydrolysis product cis-[PtCl(NH3)(2)(OH2)](+). Two major -AG- monofunctional adducts, G(6)/Cl and A(5)/Cl, form at rates of 1.06 +/- 0.06 and 0.149 +/- 0.014 M-1 s(-1), respectively. The major Pt-GA- monofunctional adduct G(5)/Cl forms at a rate of 0.023 +/- 0.002 M-1 s(-1), and several minor adducts, including A(6)/Cl (0.0054 +/- 0.0010 M-1 s(-1)), are observed. Closure from the monofunctional/Cl adducts proceeds via an aquated species for both -AG- and -GA-. The rates of hydrolysis from the G/Cl adducts to the G/H2O species are (1.55 +/- 0.05) x 10(-5) s(-1) with -AG- and (0.198 +/- 0.008) x 10(-5) s(-1) with -GA-, and the rates of closure to the chelates are (9.8 +/- 0.9) x 10(-5) and (0.69 +/- 0.17) x 10(-5) s(-1) for -AG- and -GA-, respectively. The rates of ring closure from A/Cl monofunctional species, treated as direct to chelate, are (0.16 +/- 0.06) x 10(-5) (-AG-) and (2.1 +/- 0.7) x 10(-5) s(-1) (-GA-). The rate constants found for the reactions between the oligonucleotides and cis-[Pt((NH3)-N-15)(2)(OH2)(2)](2+) are, for formation of the G/H2O monofunctional adducts, 0.42 +/- 0.01 (-AG-) and 0.50 +/- 0.01 M-1 s(-1) (-GA-). Formation of A/H2O adducts is not observed for either -AG- or -GA-. Rates of ring closure from the G/H20 adducts are (3.71 +/- 0.05) x 10(-5) (-AG-) and (0.162 +/- 0.005) x 10(-5) s(-1) (-GA-). The rate of formation of monofunctional adducts from cis-[Pt((NH3)-N-15)(2)(OH2)(2)](2+) are similar for -AG- and -GA-, whereas for cisplatin a clear preference is observed for -AG- over -GA-. Closure to form the bifunctional adduct is more rapid in the case of -AG- than -GA- for both cisplatin and cis-[Pt((NH3)-N-15)(2)(OH2)(2)](2+), but the difference is greater for cis-[Pt((NH3)-N-15)(2)(OH2)(2)](2+)(.) It is concluded that the bifunctional intrastrand adduct profile observed when cisplatin binds to DNA is substantially controlled by the rate of formation of monofunctional adducts at the different X-purine-purine-X sequences. A slow rate of closure also contributes to the nonformation of the bifunctional GpA adduct.

  DOI：

  10.1021/ja981725u