3,12-二羟基十六烷酸 | 66675-73-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 3,12-二羟基十六烷酸
• 英文名称: 3,12-dihydroxy-hexadecanoic acid
• 英文别名: β.λ-Dioxy-palmitinsaeure；2.11-Dioxy-pentadecan-carbonsaeure-(1)；3,12-Dihydroxy-hexadecansaeure；3,12-Dihydroxyhexadecanoic acid
• CAS: 66675-73-8
• 化学式: C₁₆H₃₂O₄
• 分子量: 288.428
• InChiKey: FEIUPFRYFFTGFY-UHFFFAOYSA-N

物化性质

• 熔点：
  83-84 °C
• 沸点：
  445.6±20.0 °C(Predicted)
• 密度：
  1.019±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2918199090

反应信息

• 作为反应物：
  描述：

  3,12-二羟基十六烷酸 在 chromium(III) oxide 、 硫酸 作用下， 生成 十五烷-2,11-二酮
  参考文献：
  名称：

  Votocek; Prelog, Collection of Czechoslovak Chemical Communications, vol. 1, p. 63

  摘要：

  DOI：
• 作为产物：
  描述：

  3,12-Dihydroxy-hexadecansaeure-methylester 在 氢氧化钾 作用下， 生成 3,12-二羟基十六烷酸
  参考文献：
  名称：

  Votocek; Prelog, Collection of Czechoslovak Chemical Communications, vol. 1, p. 58

  摘要：

  DOI：

文献信息

• Process for producing gamma-lactones
  申请人：UNILEVER N.V.

  公开号：EP0371568A1

  公开（公告）日：1990-06-06

  The invention provides a process for producing gamma-­lactones useful for incorporation in flavourings and fragrances, wherein a micro-organism which is acceptable for making food grade products and which does not metabolize gamma-lactones, is cultured aerobically in a culture medium containing as the substrate a hydroxy fatty acid having an even number 4 of carbon atoms between the carboxyl group and the carbon atom carrying the hydroxy group. The preferred micro-organism is a Saccharomyces cerevisiae, Debaromyces hansenii or Candida boidinii species. The gamma-hydroxy-alkanoic acid reaction product of the process is lactonized either in the fermentation broth or after separation therefrom. Especially suitable are 12-hydroxy fatty acids such as ricinoleic acid. The hydroxy fatty acid may be added either pure or as the mixture obtained by hydrolysis of an ester thereof. Enzymatic hydrolysis of such ester may be done in situ in the fermentation broth.

  本发明提供了一种生产γ-内酯的工艺，这种γ-内酯可用于调味品和香料中。在该工艺中，一种可用于制造食品级产品且不会代谢γ-内酯的微生物在一种培养基中进行有氧培养，该培养基含有一种羟基脂肪酸作为底物，该脂肪酸在羧基和带有羟基的碳原子之间具有偶数个 4 碳原子。首选的微生物是酿酒酵母菌、汉森德巴酵母菌或白色念珠菌。该工艺的γ-羟基-烷酸反应产物在发酵液中或从中分离出来后进行内酯化。特别适用的是 12-羟基脂肪酸，如蓖麻油酸。 羟基脂肪酸可以是纯脂肪酸，也可以是通过水解其酯得到的混合物。这种酯的酶水解可在发酵液中就地进行。
• Process for the isolation of hydroxy fatty acid derivatives from convolvulaceae plants
  申请人：QUEST INTERNATIONAL B.V.

  公开号：EP0409320A2

  公开（公告）日：1991-01-23

  The invention provides a process for the isolation of hydroxy fatty acid derivatives from Convolvulaceae plants like Ipomoea batatas and Ipomoea orizabensis by extracting parts of said plants like leaves, stems, seeds and in particular roots and tubers thereof, with an organic solvent, removing the solvent for at least the main part from the extract, dispersing the obtained residue into water, subjecting the obtained dispersion to a single hydrolysis step and recovering the released hydroxy fatty acids, like 11-hydroxy palmitic acid and 3,11-hydroxy myristic acid from the aqueous dispersion by means of an extraction agent. The obtained hydroxy fatty acid may be used in the synthesis of specific organic compounds like lactones or in the preparation of products having purgative properties and of thickeners for lubricating greases respectively.

  本发明提供了一种从卷叶菜科植物（如 Ipomoea batatas 和 Ipomoea orizabensis）中分离羟基脂肪酸衍生物的工艺，其方法是用有机溶剂提取上述植物的部分，如叶、茎、种子，特别是根和块茎、从提取物中去除至少主要部分的溶剂，将得到的残留物分散到水中，将得到的分散液进行单一水解步骤，并通过萃取剂从水分散液中回收释放出的羟基脂肪酸，如 11-羟基棕榈酸和 3,11- 羟基肉豆蔻酸。获得的羟基脂肪酸可用于合成特定的有机化合物，如内酯，或用于制备具有清肠特性的产品和润滑油脂的增稠剂。
• Votocek; Valentin, Collection of Czechoslovak Chemical Communications, vol. 1, p. 50,54
  作者：Votocek、Valentin

  DOI：——

  日期：——
• Votocek; Prelog, Collection of Czechoslovak Chemical Communications, vol. 1, p. 60
  作者：Votocek、Prelog

  DOI：——

  日期：——
• US4049592A
  申请人：——

  公开号：US4049592A

  公开（公告）日：1977-09-20