1-亚硝基-4-丙基苯 | 67083-39-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-亚硝基-4-丙基苯
• 英文名称: 1-propyl-4-nitrosobenzene
• 英文别名: 1-Nitroso-4-propylbenzene
• CAS: 67083-39-0
• 化学式: C₉H₁₁NO
• 分子量: 149.192
• InChiKey: XHNUYMNRCLHBFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-亚硝基-4-丙基苯 在 双氧水 、 乙酸酐 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 31.0h， 生成 oxido-(4-pentylphenyl)imino-(4-propylphenyl)azanium
  参考文献：
  名称：

  Dabrowski, Roman; Kenig, Krystyna, Bulletin of the Polish Academy of Sciences: Chemistry, 1986, vol. 34, # 5-6, p. 183 - 189

  摘要：

  DOI：
• 作为产物：
  描述：

  1-硝基-4-正-丙基苯 在 三氯化铁 、 氯化铵 、 锌 作用下， 以 乙醇 、 水 为溶剂， 反应 0.5h， 生成 1-亚硝基-4-丙基苯
  参考文献：
  名称：

  Dabrowski, Roman; Kenig, Krystyna, Bulletin of the Polish Academy of Sciences: Chemistry, 1986, vol. 34, # 5-6, p. 183 - 189

  摘要：

  DOI：

文献信息

• PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：US20150158811A1

  公开（公告）日：2015-06-11

  The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.

  本公开提供了一种光反应合成蛋白功能调节剂。本公开还提供了一种包括所述合成调节剂的光调控多肽。还提供了包括所述光调控多肽的细胞和膜。本公开还提供了一种调节蛋白功能的方法，涉及使用光。
• Lewis acid catalyzed reactivity switch: pseudo three-component annulation of nitrosoarenes and (epoxy)styrenes
  作者：Anisha Purkait、Subhajit Saha、Santanu Ghosh、Chandan K. Jana

  DOI：10.1039/d0cc02650f

  日期：——

  Lewis acid catalyzed alteration of annulation pattern allowed formation of arylquinolines via C–H functionalization of nitrosoarenes and C–C cleavage of (epoxy)styrene.

  Lewis酸催化的环化模式改变允许通过硝基芳烃的C-H官能化和（环氧）苯乙烯的C-C断裂形成芳基喹啉。
• RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE
  申请人：Kyungpook National University Industry-Academic Cooperation Foundation

  公开号：EP3281643A2

  公开（公告）日：2018-02-14

  Provided is a probe for detecting in vivo hydrogen sulfide, specifically, a probe for detecting hydrogen sulfide including a complex compound into which a radioactive isotope Cu is introduced. According to specific embodiments of the present disclosure, as a result of real-time observing animal models, in which hydrogen sulfide involved in various diseases is generated in a large quantity, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present disclosure may selectively bind with hydrogen sulfide to provide images of a site where hydrogen sulfide has abnormally increased in a cell or a tissue, thereby detecting a disease in an unexpected site without affecting the anatomical properties of the body. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, thereby solving the existing problem of waiting a predetermined time for testing after an imaging agent is injected. Accordingly, the probe may be effectively used as a means for diagnosing diseases, such as a composition for imaging, an imaging method, etc.

  提供了一种用于检测体内硫化氢的探针，具体来说，是一种用于检测硫化氢的探针，其中包括引入了放射性同位素铜的复合物。根据本公开的具体实施例，通过实时观察动物模型，可以大量生成涉及各种疾病的硫化氢，通过光学和核医学成像，根据本公开的检测硫化氢的探针可以选择性地与硫化氢结合，提供细胞或组织中硫化氢异常增加的部位的图像，从而在不影响身体解剖特性的情况下检测意外部位的疾病。此外，用于检测硫化氢的探针与硫化氢迅速反应，从而解决了注射成像剂后等待预定时间进行测试的现有问题。因此，该探针可以有效用作诊断疾病的手段，如成像组合物、成像方法等。
• Acid mediated coupling of aliphatic amines and nitrosoarenes to indoles
  作者：Subhra Kanti Roy、Anisha Purkait、Sk Md Tarik Aziz、Chandan K. Jana

  DOI：10.1039/c9cc09616g

  日期：——

  or azo compounds. Herein, we report an acid mediated annulation reaction of aliphatic amines and nitrosoarenes to provide indole derivatives. The elusive direct annulation of aliphatic amines and nitrosoarenes via simultaneous C-C and C-N bond formation was achieved under metal free conditions. This conceptually novel method for indole synthesis does not require pre-functionalization steps for the

  传统上，胺与亚硝基芳烃反应以提供相应的亚胺或偶氮化合物。在此，我们报道了脂族胺和亚硝基芳烃的酸介导的环化反应，以提供吲哚衍生物。在无金属条件下，通过同时形成CC和CN键可实现脂肪族胺和亚硝基芳烃的难以捉摸的直接环化。这种用于吲哚合成的概念上新颖的方法不需要用于新的CC和CN键形成的预功能化步骤。该方法已被用于去甲新肾上腺素和新甲肾上腺素的精细合成。
• Liquid Crystalline Properties of Substituted Azo- and Azoxy-benzenes. I
  作者：Kei Murase、Haruaki Watanabe

  DOI：10.1246/bcsj.46.3142

  日期：1973.10

  In order to obtain low-temperature mesomorphic materials, thirty-two p-alkyl-p′-alkoxy-azo- and -azoxybenzenes have been synthesized. The former have been made by the condensation of p-n-alkylnitrosobenzenes and p-n-alkoxyanilines, and the latter, by the oxidation of the former. Twenty-nine of the compounds show nematic behavior. In the majority of cases, the nematic temperature range of the azoxy compounds, which have been considered to consist of two isomers synthesized simultaneously, is appreciably wide.

  为了获得低温介形材料，我们合成了 32 种对烷基对烷氧基偶氮苯和偶氮氧苯。前者是由对-烷基亚硝基苯和对-烷氧基苯胺缩合而成，后者是由前者氧化而成。其中 29 种化合物显示出向列行为。在大多数情况下，偶氮氧基化合物的向列温度范围都很宽，它们被认为是由两种异构体同时合成的。