N-oleoyl-L-tryptophan ethyl ester | 261734-93-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-oleoyl-L-tryptophan ethyl ester
• 英文别名: N-oleoyl-tryptophanethyl-ester；ethyl (2S)-3-(1H-indol-3-yl)-2-[[(Z)-octadec-9-enoyl]amino]propanoate
• CAS: 261734-93-4
• 化学式: C₃₁H₄₈N₂O₃
• 分子量: 496.734
• InChiKey: LCMBCJFAKQBFGZ-TWKJZOCOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  36
• 可旋转键数：
  21
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  71.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-oleoyl-L-tryptophan ethyl ester 在 lithium hydroxide 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 12.0h， 以78%的产率得到N-oleoyl-L-tryptophan
  参考文献：
  名称：

  Design and Synthesis of Lipids for the Fabrication of Functional Lipidic Cubic-Phase Biomaterials

  摘要：

  A series of novel lipids with designed functionalities were synthesized. These lipids are based on conjugation of alpha-amino acids and their esters, cationic, anionic, neutral, and photochromic moieties to the lipophilic 9-cis octadecenyl chains by amide, ester, thioester, or amine bonds. Because of the plasticity of lipidic cubic phases, it is envisaged that when mixed with monooleoyl-rac-glycerol (monoolein, MO) and water at appropriate proportions, they would assemble to form bicontinuous lipidic cubic phases (LCPs) that exhibit the well-known material properties of LCPs such as phase stability, optical transparency, and chemical permeability. Moreover, due to the nature and position of the functionality at the headgroup region, we envision them to perform as functional materials by design.

  DOI：

  10.1021/jo301659c
• 作为产物：
  描述：

  油酰氯 、 L-色氨酸乙酯盐酸盐 在 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 以92%的产率得到N-oleoyl-L-tryptophan ethyl ester
  参考文献：
  名称：

  Design and Synthesis of Lipids for the Fabrication of Functional Lipidic Cubic-Phase Biomaterials

  摘要：

  A series of novel lipids with designed functionalities were synthesized. These lipids are based on conjugation of alpha-amino acids and their esters, cationic, anionic, neutral, and photochromic moieties to the lipophilic 9-cis octadecenyl chains by amide, ester, thioester, or amine bonds. Because of the plasticity of lipidic cubic phases, it is envisaged that when mixed with monooleoyl-rac-glycerol (monoolein, MO) and water at appropriate proportions, they would assemble to form bicontinuous lipidic cubic phases (LCPs) that exhibit the well-known material properties of LCPs such as phase stability, optical transparency, and chemical permeability. Moreover, due to the nature and position of the functionality at the headgroup region, we envision them to perform as functional materials by design.

  DOI：

  10.1021/jo301659c

文献信息

• Pigment dispersant with hindered light amine stabilizer and pigment dispersions and coating compositions based thereon
  申请人：PPG Industries Ohio, Inc.

  公开号：US10557045B2

  公开（公告）日：2020-02-11

  A pigment dispersion is disclosed comprising (a) at least one pigment and (b) a polymeric dispersant comprising residual units derived from polymerization of a mixture of monomers comprising (b1) at least one ethylenically unsaturated hindered amine light stabilizing monomer and (b2) at least one additional ethylenically unsaturated monomer different from monomer (b1). Coating compositions comprising the same are also disclosed as are substrates coated at least in part with such coatings.

  本发明公开了一种颜料分散剂，包括(a)至少一种颜料和(b)聚合物分散剂，聚合物分散剂由单体混合物聚合产生的残留单元组成，单体混合物包括(b1)至少一种乙烯基不饱和受阻胺光稳定单体和(b2)至少一种不同于单体(b1)的额外乙烯基不饱和单体。此外，还公开了包含上述成分的涂层组合物，以及至少部分涂有此类涂层的基材。
• Tryptophanyl-esters and their n-acyl derivatives for preventing and treating diseases caused or aggravated by oxidation processes
  申请人：——

  公开号：US20010014695A1

  公开（公告）日：2001-08-16

  Use of a tryptophanyl-ester or an N-acyl derivative of a tryptophanyl-ester for the prophylaxis and therapy of oxidative pathologic processes in degenerative diseases and/or cancer diseases. Thereby, the tryptophanyl-ester or its N-acyl derivative is preferred to be tryptophanoctyl, N-oleoyl-tryptophanethyl-ester or N-dodecanoyl-tryptophanethyl-ester. Futhermore the tryptophanyl-esters and their N-acyl derivatives are preferred to be used for the treatment and/or prophylaxis of neurodegenerative diseases, cataracts,- neoplastic diseases and/or cardiovascular diseases. In particular, the invention relates to the use of the tryptophanyl-esters and their N-acyl derivatives for the treatment and/or prophylaxis of Alzheimer's disease, Parkinson's disease, apoplectic fit, amyotrophic lateral sclerosis, cancers, arteriosclerosis and/or myocardial infarction. In addition, the invention relates to a pharmaceutical composition comprising a tryptophanyl-ester or an N-acyl derivative of a tryptophanyl-ester.

  将色氨酸酯或色氨酸酯的 N-酰基衍生物用于预防和治疗退行性疾病和/或癌症中的氧化病理过程。因此，色氨酸酯或其 N-酰基衍生物最好是色氨酸辛酯、N-油酰-色氨酸乙酯或 N-十二酰-色氨酸乙酯。 此外，色氨酰酯及其 N-酰基衍生物最好用于治疗和/或预防神经退行性疾病、白内障、肿瘤性疾病和/或心血管疾病。特别是，本发明涉及色氨酸酯及其 N-酰基衍生物用于治疗和/或预防阿尔茨海默病、帕金森病、无痫症、肌萎缩性脊髓侧索硬化症、癌症、动脉硬化和/或心肌梗塞。 此外，本发明还涉及一种药物组合物，其中包含一种色氨酰酯或一种色氨酰酯的 N-酰基衍生物。
• Ethylenically unsaturated amine salts of sulfonic, phosphoric, and carboxylic acids
  申请人：Stepan Company

  公开号：US20010018461A1

  公开（公告）日：2001-08-30

  Disclosed are ethylenically unsaturated amine salts of sulfonic, phosphoric and carboxylic acids. The salts are surface active agents which are useful in a variety of applications as primary and/or secondary surfactants. The salts are especially useful as surfactants in emulsion polymerization reactions.

  本发明公开了磺酸、磷酸和羧酸的乙烯不饱和胺盐。这些盐类是表面活性剂，在各种应用中可用作一级和/或二级表面活性剂。这些盐在乳液聚合反应中作为表面活性剂尤其有用。
• Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealant, adhesives and elastomers produced from such latexes
  申请人：Stepan Company

  公开号：US20020040092A1

  公开（公告）日：2002-04-04

  Disclosed are antibacterial CASE materials comprising a latex comprising polymer particles and a surfactant component. Also disclosed are components and methods for forming such materials.

  所公开的抗菌 CASE 材料由包含聚合物颗粒和表面活性剂成分的胶乳组成。还公开了形成这种材料的成分和方法。
• Emulsion polymerization process utilizing ethylenically unsaturated amine salts of sulfonic, phosphoric and carboxylic acids
  申请人：STEPAN COMPANY, A corporation of the State of Delaware

  公开号：US20020161108A1

  公开（公告）日：2002-10-31

  Disclosed is an improved method of making polymers. The method utilizes at least one ethylenically unsaturated monomer and at least one polymerizable surface active agent. The polymerizable surface active agent is capable of co-polymerization with traditional monomers and/or polymerization with itself (i.e. homopolymerization) and is preferably substantially completely consumed during the course of the polymerization. Polymers produced by the method of the present invention are well suited for use in coatings, adhesives, sealants, elastomers and the like, as they form stable films, possess excellent adhesion properties and have improved hydrolytic stability characteristics. The present invention also encompasses homopolymeric surface active agents and their use in polymerization reactions.

  本发明公开了一种改进的聚合物制造方法。该方法利用至少一种乙烯基不饱和单体和至少一种可聚合表面活性剂。可聚合表面活性剂能与传统单体共聚合和/或与自身聚合（即均聚），最好在聚合过程中完全消耗。用本发明的方法生产的聚合物非常适合用于涂料、粘合剂、密封剂、弹性体等，因为它们能形成稳定的薄膜，具有优异的粘合性能和更好的水解稳定性。本发明还包括均聚物表面活性剂及其在聚合反应中的应用。