H-Gly-pramipexole(boc) | 1263786-87-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Gly-pramipexole(boc)
• 英文别名: tert-butyl N-[(6S)-2-[(2-aminoacetyl)amino]-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]-N-propylcarbamate
• CAS: 1263786-87-3
• 化学式: C₁₇H₂₈N₄O₃S
• 分子量: 368.5
• InChiKey: FUFRITMOTONPDR-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] HIGH-LOADING WATER-SOLUBLE CARRIER-LINKED PRODRUGS<br/>[FR] PROMÉDICAMENTS LIÉS À DES EXCIPIENTS HYDROSOLUBLES DE FORTE CHARGE
  申请人：ASCENDIS PHARMA AS

  公开号：WO2013024047A1

  公开（公告）日：2013-02-21

  The present invention relates to water-soluble carrier-linked prodrugs of formula (I), wherein B, A and Hyp form the carrier, B is a branching core, each A is independently a poly(ethylene glycol)-based polymeric chain, each Hyp is independently a branched moiety, each SP is independently a spacer moiety, each L is independently a reversible prodrug linker moiety, each D is independendly a biologically active moiety, each x is independently 0 or 1, each m is independently an integer of from 2 to 64, n is an integer from 3 to 32; or the pharmaceutically acceptable salt thereof. It further relates to pharmaceutical compositions comprising said water-soluble carrier-linked prodrugs, their use asmedicament or diagnostic, and methods of treatment.

  本发明涉及水溶性载体连接的前药，其化学式为(I)，其中B、A和Hyp形成载体，B是一个分支核心，每个A独立地是一条聚乙二醇基聚合链，每个Hyp独立地是一个分支基团，每个SP独立地是一个间隔基团，每个L独立地是一个可逆前药连接基团，每个D独立地是一个生物活性基团，每个x独立地为0或1，每个m独立地是从2到64的整数，n是从3到32的整数；或其药学上可接受的盐。进一步涉及包括所述水溶性载体连接的前药的药物组合物，其用作药物或诊断，以及治疗方法。
• CARRIER LINKED PRAMIPEXOLE PRODRUGS
  申请人：Rau Harald

  公开号：US20120191039A1

  公开（公告）日：2012-07-26

  The present invention relates to a carrier linked pramipexole prodrug or a pharmaceutical acceptable salt thereof, wherein pramipexole is bound via a linker to a polymeric carrier. The invention also relates to pharmaceutical compositions comprising said polymeric pramipexole prodrug and their use as medicaments.

  本发明涉及一种与载体连接的普拉米匹索尔前药或其药学上可接受的盐，其中普拉米匹索尔通过链节与聚合物载体结合。本发明还涉及包含所述聚合物普拉米匹索尔前药的药物组合物及其作为药物的使用。
• High-Loading Water-Soluable Carrier-Linked Prodrugs
  申请人：Hersel Ulrich

  公开号：US20140296257A1

  公开（公告）日：2014-10-02

  The present invention relates to water-soluble carrier-linked prodrugs of formula (I), wherein B, A and Hyp form the carrier, B is a branching core, each A is independently a poly(ethylene glycol)-based polymeric chain, each Hyp is independently a branched moiety, each SP is independently a spacer moiety, each L is independently a reversible prodrug linker moiety, each D is independently a biologically active moiety, each x is independently 0 or 1, each m is independently an integer of from 2 to 64, n is an integer from 3 to 32; or the pharmaceutically acceptable salt thereof. It further relates to pharmaceutical compositions comprising said water-soluble carrier-linked prodrugs, their use as medicament or diagnostic, and methods of treatment.
• [EN] CARRIER LINKED PRAMIPEXOLE PRODRUGS<br/>[FR] PROMÉDICAMENTS DE PRAMIPEXOLE LIÉS À UN SUPPORT
  申请人：ASCENDIS PHARMA AS

  公开号：WO2011012721A1

  公开（公告）日：2011-02-03

  The present invention relates to a carrier linked pramipexole prodrug or a pharmaceutical acceptable salt thereof, wherein pramipexole is bound via a linker to a polymeric carrier. The invention also relates to pharmaceutical compositions comprising said polymeric pramipexole prodrug and their use as medicaments.
• [EN] INJECTABLE SUSTAINED RELEASE COMPOSITIONS COMPRISING A PRAMIPEXOLE PRODRUG<br/>[FR] COMPOSITIONS INJECTABLES À LIBÉRATION PROLONGÉE CONTENANT UN PROMÉDICAMENT DU PRAMIPEXOLE
  申请人：ASCENDIS PHARMA AS

  公开号：WO2011012723A1

  公开（公告）日：2011-02-03

  The present invention relates to an injectable slow release pharmaceutical composition containing a carrier linked pramipexole prodrug. The invention also relates to their use as medicaments.