1-(3-(1-hydroxyethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-1-methyl-3-phenethylthiourea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(3-(1-hydroxyethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-1-methyl-3-phenethylthiourea
• 英文别名: 1-((2S,3R,12bS)-3-((S)-1-hydroxyethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-1-methyl-3-phenethylthiourea；1-[(2S,3R,12bS)-3-[(1S)-1-hydroxyethyl]-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-1-methyl-3-(2-phenylethyl)thiourea
• 化学式: C₂₇H₃₄N₄OS
• 分子量: 462.659
• InChiKey: ZUFTYJAAQFWNFT-DMGDPNCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,9-二氢-3H-吡啶并(3,4-B)吲哚 在 sodium tetrahydroborate 、 lithium aluminium tetrahydride 、 nickel(II) chloride hexahydrate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 6.92h， 生成 1-(3-(1-hydroxyethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-1-methyl-3-phenethylthiourea
  参考文献：
  名称：

  Multicomponent Assembly Processes for the Synthesis of Diverse Yohimbine and Corynanthe Alkaloid Analogues

  摘要：

  A strategy involving a Mannich-type multi-component assembly process followed by a 1,3-dipolar cycloaddition has been developed for the rapid and efficient construction of parent heterocyclic scaffolds bearing indole and isoxazolidine rings. These key intermediates were then readily elaborated using well-established protocols for refunctionalization and cross-coupling to access a diverse 180-member library of novel pentacyclic and tetracyclic compounds related to the Yohimbine and Corynanthe alkaloids. Several other new multicomponent assembly processes were developed to access dihydro-beta-carboline-fused benzodiazepines, pyrimidinediones, and rutaecarpine derivatives.

  DOI：

  10.1021/co400055b

文献信息

• Multicomponent Assembly Processes for the Synthesis of Diverse <i>Yohimbine</i> and <i>Corynanthe</i> Alkaloid Analogues
  作者：Brett A. Granger、Zhiqian Wang、Kyosuke Kaneda、Zhenglai Fang、Stephen F. Martin

  DOI：10.1021/co400055b

  日期：2013.7.8

  A strategy involving a Mannich-type multi-component assembly process followed by a 1,3-dipolar cycloaddition has been developed for the rapid and efficient construction of parent heterocyclic scaffolds bearing indole and isoxazolidine rings. These key intermediates were then readily elaborated using well-established protocols for refunctionalization and cross-coupling to access a diverse 180-member library of novel pentacyclic and tetracyclic compounds related to the Yohimbine and Corynanthe alkaloids. Several other new multicomponent assembly processes were developed to access dihydro-beta-carboline-fused benzodiazepines, pyrimidinediones, and rutaecarpine derivatives.