(S)-(-)-3-(4-aminophenyl)-2-methoxypropionic acid | 921195-94-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (S)-(-)-3-(4-aminophenyl)-2-methoxypropionic acid
• 英文别名: (S)-2-methoxy-3-(4’-aminophenyl)propionic acid；GED-0507-34-Levo；(2S)-3-(4-aminophenyl)-2-methoxypropanoic acid
• CAS: 921195-94-0
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: QLJYLJGYIDIJPT-VIFPVBQESA-N

物化性质

• 沸点：
  381.3±27.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-(-)-3-(4-aminophenyl)-2-methoxypropionic acid 、 乙酸酐 以 乙酸乙酯 为溶剂， 反应 1.75h， 以154.5 kg的产率得到(S)-3-(4-acetamidophenyl)-2-methoxypropanoic acid
  参考文献：
  名称：

  [EN] PROCESS OF MAKING 3-(4'-AMINOPHENYL)-2-METHOXYPROPIONIC ACID, AND ANALOGS AND INTERMEDIATES THEREOF
  [FR] PROCÉDÉ DE FABRICATION D'ACIDE 3-(4'-AMINOPHÉNYL)-2-MÉTHOXYPROPIONIQUE, ET ANALOGUES ET INTERMÉDIAIRES DE CELUI-CI

  摘要：

  公开号：

  WO2020161362A9
• 作为产物：
  描述：

  2-甲氧基-3-(4-硝基苯基)丙烯酸甲酯 在 ammonium hydroxide 、 磷酸 、 5%-palladium/activated carbon 、 氢气 作用下， 以 甲醇 、 水 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 丙酮 、 甲苯 为溶剂， 80.0 ℃ 、455.99 kPa 条件下， 反应 2.92h， 生成 (S)-(-)-3-(4-aminophenyl)-2-methoxypropionic acid
  参考文献：
  名称：

  [EN] PROCESS OF MAKING 3-(4'-AMINOPHENYL)-2-METHOXYPROPIONIC ACID, AND ANALOGS AND INTERMEDIATES THEREOF
  [FR] PROCÉDÉ DE FABRICATION D'ACIDE 3-(4'-AMINOPHÉNYL)-2-MÉTHOXYPROPIONIQUE, ET ANALOGUES ET INTERMÉDIAIRES DE CELUI-CI

  摘要：

  公开号：

  WO2020161362A9

文献信息

• Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them
  申请人：Bhuniya Debnath

  公开号：US20050113368A1

  公开（公告）日：2005-05-26

  The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I) their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. The present invention also relates to processes for the preparation of the compounds of formula (I), novel intermediates, processes for their preparation, their use in the preparation of the above said compounds and their use as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds.

  本发明涉及公式（I）的新型抗糖尿病、降脂、抗肥胖和降胆固醇化合物及其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和包含它们的药学上可接受的组合物，以及制备这些化合物的方法。更具体地说，本发明涉及一般的烷基羧酸及其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和包含它们的药学上可接受的组合物，以及制备这些化合物的方法。本发明还涉及公式（I）化合物的制备方法、新型中间体的制备方法、以及它们在制备上述化合物和作为抗糖尿病、降脂、抗肥胖和降胆固醇化合物的用途。
• METHODS OF TREATING HAIR RELATED CONDITIONS
  申请人：NOGRA PHARMA LIMITED

  公开号：US20150250749A1

  公开（公告）日：2015-09-10

  Provided herein are methods for enhancing epidermal regeneration in a patient in need thereof, comprising topically administering to said patient a pharmaceutically acceptable composition comprising N-acetyl-3-(4-aminophenyl)-2-methoxypropionic acid or a pharmaceutically acceptable salt or stereoisomer thereof, and a pharmaceutically acceptable excipient. For example, provided are methods for treating or ameliorating cicatricial alopecia, comprising topically administering to a patient in need thereof a pharmaceutically acceptable composition comprising the disclosed compounds. Also provided are methods for protecting hair follicle progenitor cells and compositions comprising same using the disclosed compounds.

  本文提供了一种增强病人表皮再生的方法，包括将一种药学上可接受的组合物局部施用于该病人，所述组合物包括N-乙酰基-3-(4-氨基苯基)-2-甲氧基丙酸或其药学上可接受的盐或立体异构体，以及药学上可接受的赋形剂。例如，本文提供了治疗或改善瘢痕性脱发的方法，包括将所述化合物的药学上可接受的组合物局部施用于需要治疗的病人。同时，本文还提供了使用所述化合物保护毛囊祖细胞的方法和组合物。
• Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field
  申请人：Nogra Pharma Limited

  公开号：US20150265563A1

  公开（公告）日：2015-09-24

  The present invention relates to compounds comprising the general formula (I), in which R 1 and R 2 , which may be identical or different, are selected from the group comprising —H or a linear or branched alkyl group having from 1 to 6 carbon atoms or together form an aromatic or aliphatic ring with 5 or 6 atoms; Y and Z, which may be identical or different, are selected from the group comprising —H, —OH, —COOH, —OR 3 , —CH(OR 3 )COOH, in which R 3 is selected from H, phenyl, benzyl, —CF 3 or —CF 2 CF 3 , vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms.

  本发明涉及通式（I）的化合物，其中R1和R2可以相同或不同，选自包括-H或具有1至6个碳原子的线性或支链烷基或共同形成具有5或6个原子的芳香或脂肪环的群；Y和Z可以相同或不同，选自包括-H，-OH，-COOH，-OR3，-CH（OR3）COOH的群，其中R3选自H，苯基，苄基，-CF3或-CF2CF3，乙烯基，丙烯基和具有1至6个碳原子的线性或支链烷基。
• METHODS OF INHIBITING HAIR GROWTH
  申请人：NOGRA PHARMA LIMITED

  公开号：US20150265514A1

  公开（公告）日：2015-09-24

  Provided herein are methods for reducing mammalian hair growth using the disclosed compounds. Also provided herein are methods of inhibiting hair growth after hair removal of an area of mammalian skin of a mammal using the disclosed compounds.

  本文提供了使用所披露的化合物减少哺乳动物毛发生长的方法。本文还提供了使用所披露的化合物抑制哺乳动物皮肤某个区域的毛发在脱毛后生长的方法。
• Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field
  申请人：Nogra Pharma Limited

  公开号：US10016381B2

  公开（公告）日：2018-07-10

  The present invention relates to compounds comprising the general formula (I), in which R1 and R2, which may be identical or different, are selected from the group comprising —H or a linear or branched alkyl group having from 1 to 6 carbon atoms or together form an aromatic or aliphatic ring with 5 or 6 atoms; Y and Z, which may be identical or different, are selected from the group comprising —H, —OH, —COOH, —OR3, —CH(OR3)COOH, in which R3 is selected from H, phenyl, benzyl, —CF3 or —CF2CF3, vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms.

  本发明涉及包含通式(I)的化合物，其中 R1 和 R2（可以相同或不同）选自-H 或具有 1 至 6 个碳原子的直链或支链烷基，或共同形成具有 5 或 6 个原子的芳香族或脂肪族环；Y 和 Z（可以相同或不同）选自-H、-OH、-COOH、-OR3、-CH(OR3)COOH 组，其中 R3 选自 H、苯基、苄基、-CF3 或-CF2CF3、乙烯基、烯丙基和具有 1 至 6 个碳原子的直链或支链烷基。