1-ethyl-4-phenylethylene glycol | 19594-02-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-ethyl-4-phenylethylene glycol
• 英文别名: (2-ethoxyethoxy)benzene；1-ethoxy-2-phenoxy-ethane；1-Aethoxy-2-phenoxy-aethan；α-Aethoxy-β-phenoxy-aethan；Aethylenglykol-aethyl-phenyl-aether；Benzene, (2-ethoxyethoxy)-；2-ethoxyethoxybenzene
• CAS: 19594-02-6
• 化学式: C₁₀H₁₄O₂
• mdl: MFCD20390261
• 分子量: 166.22
• InChiKey: DIUJNXCPDGGFQD-UHFFFAOYSA-N

物化性质

• 沸点：
  230°C (estimate)
• 密度：
  1.0180

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-ethyl-4-phenylethylene glycol 在 Rh/Al₂O₃ 氢气 作用下， 以 甲醇 为溶剂， 40.0 ℃ 、4.14 MPa 条件下， 生成 2-Ethoxyethyl-cyclohexyl-ether
  参考文献：
  名称：

  Buchanan, G. W.; Moghimi, A.; Reynolds, V. M., Canadian Journal of Chemistry, 1995, vol. 73, # 4, p. 566 - 572

  摘要：

  DOI：
• 作为产物：
  描述：

  potassium phenolate 在 potassium carbonate 作用下， 生成 1-ethyl-4-phenylethylene glycol
  参考文献：
  名称：

  Henry, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1883, vol. 96, p. 1233

  摘要：

  DOI：

文献信息

• Air-stable palladium(0) phosphine sulfide catalysts for Ullmann-type C–N and C–O coupling reactions
  作者：Arpi Majumder、Ragini Gupta、Mrinmay Mandal、Madhu Babu、Debashis Chakraborty

  DOI：10.1016/j.jorganchem.2014.11.018

  日期：2015.4

  N-arylation and O-arylation of aryl halides by Ullmann-type cross coupling reaction under mild reaction conditions in a short reaction time. Two phosphine sulphide ligands and their corresponding Pd(0) complexes namely [Pd(p2S2)(dba)] and [Pd(pp3S4)(dba)], were synthesized, where p2S2 is 1,2-bis(diphenylphosphino)ethane disulfide, pp3S4 is tris[2-(diphenylphosphino)ethyl]phosphine tetrasulfide and dba

  本文描述了在温和的反应条件下，在较短的反应时间内，钯（0）催化Ullmann型交叉偶联反应进行芳基卤化物的N-芳基化和O-芳基化的有效方法。合成了两个硫化膦配体及其相应的Pd（0）络合物，即[Pd（p 2 S 2）（dba）]和[Pd（pp 3 S 4）（dba）]，其中p 2 S 2为1， 2-双（二苯基膦基）乙烷二硫化物，pp 3 S 4是三[2-（二苯基膦基）乙基]膦四硫化物，dba是二亚苄基丙酮。通过改变温度，溶剂，碱和催化剂的负载量，确定了使用碘代苯和苯并咪唑进行芳基化反应的最佳反应条件。使用碘代苯/溴苯和具有不同空间和电子性质的各种取代的芳基胺/苯酚/醇进行交叉偶联反应，从而以良好或优异的收率得到所需的N-芳基胺/二芳基醚/烷基芳基醚（ 70–94％）。
• NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS
  申请人：Chu Daniel

  公开号：US20100105607A1

  公开（公告）日：2010-04-29

  Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of the a glycopeptide (Compound A, Compound B, Compound H or Compound C) or the monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; conversion of the amide group in amino acid-3 on these scaffolds to various acylamide, acylsulfonamide, acylsulfonylurea derivatives; aminomethylation with substituent containing sulfonamide or acylsulfonamide group on amino acid-7 through Mannich reaction; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

  所描述的具有抗菌活性的半合成糖肽，特别是这里描述的半合成糖肽是通过对一种糖肽（化合物A、化合物B、化合物H或化合物C）进行化学修饰制备的，或者通过在酸性介质中水解氨基酸-4的二糖基团以得到氨基酸-4单糖基团；将单糖转化为氨基糖衍生物；用特定酰基对这些支架上氨基酸-4氨基取代糖基团上的氨基取代基进行酰化；将这些支架上氨基酸-3中的酰胺基团转化为各种酰胺、酰磺酰胺、酰磺酰脲衍生物；通过曼尼希反应在氨基酸-7上含有磺胺基或酰磺酰胺基团的取代基上进行氨甲基化；以及将这些支架上大环环上的酸基团转化为特定取代酰胺。还提供了合成这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物用于治疗和/或预防疾病，特别是细菌感染的方法。
• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE
  申请人：Arvinas, Inc.

  公开号：US20180177750A1

  公开（公告）日：2018-06-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of enhancer of zeste homolog 2 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为增强子锁定同源2的调节剂而发挥作用。具体而言，本公开涉及包含一端为Von Hippel-Lindau、cereblon、凋亡抑制蛋白或鼠双分子同源2配体的双功能化合物，该配体与相应的E3泛素连接酶结合，另一端含有结合目标蛋白的基团，使目标蛋白靠近泛素连接酶以实现目标蛋白的降解（和抑制）。本公开展示了与目标蛋白的降解/抑制相关的广泛药理活性范围。本公开的化合物和组合物用于治疗或预防由目标蛋白聚集或积累导致的疾病或紊乱。
• ALPHA-ARYLMETHOXYACRYLATE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
  申请人：Kim Se-Won

  公开号：US20120149707A1

  公开（公告）日：2012-06-14

  The present invention relates to an alpha-arylmethoxyacrylate derivative, a preparation method thereof and a pharmaceutical composition comprising the same, and the alpha-arylmethoxyacrylate derivative is inhibitory of HIF, which plays an important role in the regulation of genes associated with energy metabolism, vasomotion, angiogenesis and apoptosis and in the response of cells under hypoxic conditions, so that it can be used for preventing or treating of diseases such as cancer, arthritis, psoriasis, diabetic retinopathy and macular degeneration.

  本发明涉及一种α-芳基甲氧基丙烯酸酯衍生物，其制备方法及包含其的药物组合物，该α-芳基甲氧基丙烯酸酯衍生物对HIF具有抑制作用，HIF在调控与能量代谢、血管运动、血管生成和细胞在缺氧条件下的反应相关的基因方面起着重要作用，因此可用于预防或治疗癌症、关节炎、银屑病、糖尿病视网膜病变和黄斑变性等疾病。
• COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE
  申请人：SHY Therapeutics LLC

  公开号：US20170174699A1

  公开（公告）日：2017-06-22

  Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.

  本文提供了抑制MAPK磷酸化的化合物，因此可用于治疗癌症和炎症性疾病的组合物和方法。