5-acetamidomethyl-3-phenyl-1,3-oxazolidin-2-one | 367925-77-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-acetamidomethyl-3-phenyl-1,3-oxazolidin-2-one
• 英文别名: (l)-N-(3-phenyl-2-oxooxazolidin-5-ylmethyl)acetamide；N-[(3-phenyl-2-oxo-5-oxazolidinyl)methyl]acetamide；N-((2-oxo-3-phenyloxazolidin-5-yl)methyl)acetamide；N-[(2-oxo-3-phenyl-1,3-oxazolidin-5-yl)methyl]acetamide
• CAS: 367925-77-7
• 化学式: C₁₂H₁₄N₂O₃
• 分子量: 234.255
• InChiKey: ZWTBIVLRHWDITL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-acetamidomethyl-3-phenyl-1,3-oxazolidin-2-one 在 氯磺酸 作用下， 以 水 、 丙酮 为溶剂， 生成 (l)-N-[3-(4-Azidosulfonylphenyl)-2-oxooxazolidin-5-ylmethyl]acetamide
  参考文献：
  名称：

  Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents

  摘要：

  新型氨甲基氧噁唑啉基苯衍生物，包括硫化物、亚硫酸盐、磺酰化物和磺酰胺，例如（l）-N-[3-[4-(甲基亚磺酰基)苯基]-2-氧噁唑啉-5-基甲基]乙酰胺，具有有用的抗菌活性。

  公开号：

  US04705799A1
• 作为产物：
  描述：

  5-azidomethyl-3-phenyl-1,3-oxazolidin-2-one 在 palladium on activated charcoal 氢气 作用下， 以 吡啶 、 甲醇 为溶剂， 反应 2.0h， 生成 5-acetamidomethyl-3-phenyl-1,3-oxazolidin-2-one
  参考文献：
  名称：

  Synthesis of Oxazolidinones by a Solid-Phase/Activation Cycloelimination (SP/ACE) Methodology

  摘要：

  A versatile method for the solid-phase synthesis of oxazolidinones is described, An appropriate 1,2-diol is attached to immobilized sulfonyl chloride, resulting in the selective activation of one of the alcohol functions, The subsequent reaction of the other alcohol group with an isocyanate, followed by a base-promoted cycloelimination gives an oxazolidinone, By proper choice of isocyanates, functionalities can be introduced which are essential for antibiotic activity.

  DOI：

  10.1002/1099-0690(200108)2001:15<2965::aid-ejoc2965>3.0.co;2-z

文献信息

• Aminomethyloxooxazolidinyl arylbenzene derivatives useful as
  申请人：E. I. du Pont de Nemours and Company

  公开号：US04948801A1

  公开（公告）日：1990-08-14

  Novel aminomethyloxooxazolidinyl arylbenzene derivatives, wherein the aryl includes the phenyl, substituted phenyl, pyridyl, and substituted pyridyl groups, such as (l)-N-3-[4-(4'-pyridyl)phenyl]-2-oxooxazolidin-5-ylmethylacetamide, possess useful antibacterial activity.

  新型氨甲氧羰氧噁唑啉基芳基苯衍生物，其中芳基包括苯基、取代苯基、吡啶基和取代吡啶基等，例如（l）-N-3-[4-(4'-吡啶基)苯基]-2-氧氧噁唑啉-5-基甲基}乙酰胺，具有有用的抗菌活性。
• Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US04977173A1

  公开（公告）日：1990-12-11

  Aminomethyl oxooxazolidinyl ethenylbenzene derivatives, including the nitriles, sulfoxides, acetamides and nitro compounds, such as l-N-[3-[4-(E-1-methyl-2-cyanoethenyl)phenyl]-2-oxooxazolidin-5-ylmethyl]ac etamide, possess useful antibacterial activity.

  氨甲基氧氧噁唑基乙烯基苯衍生物，包括腈、亚砜、乙酰胺和硝基化合物，如l-N-[3-[4-(E-1-甲基-2-氰基乙烯基)苯基]-2-氧氧噁唑-5-基甲基]乙酰胺，具有有用的抗菌活性。
• Oxazolidinone combinatorial libraries, compositions and methods of preparation
  申请人：——

  公开号：US20020183371A1

  公开（公告）日：2002-12-05

  Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

  本发明提供了噁唑烷酮及其合成方法。还提供了包含噁唑烷酮的组合式文库以及制备这些文库的方法。此外，还提供了制备生物活性噁唑烷酮以及包含这些噁唑烷酮的药用组合物的方法。文库制备方法包括将噁唑烷酮附着到固体支持上。在一种实施例中，化合物制备方法涉及使用亚胺磷酰胺与含羰基的聚合物支持物反应。
• Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0127902A2

  公开（公告）日：1984-12-12

  Novel aminomethyl oxooxazolidinyl benzene derivatives, including the sulfides, sulfoxides, sulfones and sulfonamides, such as (I)-N-[3-[4- (methylsulfonyl) phenyl] -2- oxooxazolidin -5- ylmethyl] carbamic acid, methyl ester possess useful antibacterial activity.

  新型氨甲基恶恶唑烷基苯衍生物，包括硫化物、硫醚、砜和磺酰胺，如 (I)-N-[3-[4-（甲基磺酰基）苯基] -2- 恶恶唑烷-5-甲基]氨基甲酸甲酯，具有有用的抗菌活性。
• Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
  申请人：THE DU PONT MERCK PHARMACEUTICAL COMPANY

  公开号：EP0352781A2

  公开（公告）日：1990-01-31

  Novel aminomethyloxooxazolidinyl arylbenzene derivatives, wherein the aryl includes the phenyl, substituted phenyl, pyridyl, and substituted pyridyl groups, such as (ℓ)-N-3-[4-(4'-pyridyl)phenyl]-2-oxooxazolidin-5-ylmethyl}acetamide, possess useful antibacterial activity.

  新型氨甲基氧恶唑烷基芳基苯衍生物（其中芳基包括苯基、取代苯基、吡啶基和取代吡啶基），如 (ℓ)-N-3-[4-(4'-pyridyl)phenyl]-2-oxooxazolidin-5-ylmethyl}acetamide 具有有用的抗菌活性。