N-(4-aminobutyl)octadecanamide | 762205-15-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(4-aminobutyl)octadecanamide
• CAS: 762205-15-2
• 化学式: C₂₂H₄₆N₂O
• 分子量: 354.62
• InChiKey: PDKVPYKQBCYMPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  25
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  硬脂酸 在 吡啶 、 氯化亚砜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 11.17h， 生成 N-(4-aminobutyl)octadecanamide
  参考文献：
  名称：

  Fabrication of Nanotubules and Microspheres from the Self-Assembly of Amphiphilic Monochain Stearic Acid Derivatives

  摘要：

  A series of amphiphilic monochain derivatives of stearic acid, CH3(CH2)(16)CONH(CH2)(n)NH2 (n = 2, 3, 4, 6), CH3(CH2)(16)CONH(CH2)(2)S-2(CH2)(2)NH2, and [CH3(CH2)(16)CONH](2)(CH2)(2), are synthesized, and their self-assembly behaviors have been investigated in 1,2-dichloroethane (DCE). In addition to the concentration of the compound in DCE, the number of methylene units in hydrophilic segments play a crucial role in determining the final morphology of self-assembling structures from nanotubules with 20 nm inner diameter to microspheres with an average diameter of 20 mu m. The external texture of the microsphere is also influenced by the number of methylene units in the hydrophilic segment. The microspheres formed by highly ordered aggregattion of nanobelts show high thermal stability. The particular processes and causations have been expatiated.

  DOI：

  10.1021/la103480p

文献信息

• IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS
  申请人：GE Healthcare AS

  公开号：EP1073473B1

  公开（公告）日：2007-10-17
• Fabrication of Nanotubules and Microspheres from the Self-Assembly of Amphiphilic Monochain Stearic Acid Derivatives
  作者：Lidong Zhang、Haiqing Li、Chang Sik Ha、Hongsuk Suh、Il Kim

  DOI：10.1021/la103480p

  日期：2010.12.7

  A series of amphiphilic monochain derivatives of stearic acid, CH3(CH2)(16)CONH(CH2)(n)NH2 (n = 2, 3, 4, 6), CH3(CH2)(16)CONH(CH2)(2)S-2(CH2)(2)NH2, and [CH3(CH2)(16)CONH](2)(CH2)(2), are synthesized, and their self-assembly behaviors have been investigated in 1,2-dichloroethane (DCE). In addition to the concentration of the compound in DCE, the number of methylene units in hydrophilic segments play a crucial role in determining the final morphology of self-assembling structures from nanotubules with 20 nm inner diameter to microspheres with an average diameter of 20 mu m. The external texture of the microsphere is also influenced by the number of methylene units in the hydrophilic segment. The microspheres formed by highly ordered aggregattion of nanobelts show high thermal stability. The particular processes and causations have been expatiated.