N-(2-amino-ethyl)-hexanamide | 53673-22-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2-amino-ethyl)-hexanamide
• 英文别名: N-(2-Amino-aethyl)-hexanamid；N-(2-Aminoethyl)hexanamide
• CAS: 53673-22-6
• 化学式: C₈H₁₈N₂O
• 分子量: 158.244
• InChiKey: IPBWOMKDDFZNJQ-UHFFFAOYSA-N

物化性质

• 沸点：
  135 °C
• 密度：
  0.929±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  烟酸乙酯 、 N-(2-amino-ethyl)-hexanamide 生成 nicotinic acid-(2-hexanoylamino-ethylamide)
  参考文献：
  名称：

  Derivatives of Pyridine Acids. I. N-(2-Acylaminoethyl)-nicotinamides

  摘要：

  DOI：

  10.1021/ja01242a033
• 作为产物：
  描述：

  正己酸乙酯 、 乙二胺 生成 N-(2-amino-ethyl)-hexanamide
  参考文献：
  名称：

  Aspinall, Journal of the American Chemical Society, 1939, vol. 61, p. 3196

  摘要：

  DOI：

文献信息

• .beta.-Adrenergic blocking agents. 19. 1-Phenyl-2-[[(substituted-amido)alkyl]amino]ethanols
  作者：M. S. Large、L. H. Smith

  DOI：10.1021/jm00176a002

  日期：1980.2

  series of derivatives of 1-phenyl-2-[[(substituted amido)alkyl]amino]ethanols is described. The compounds were investigated for beta-adrenoceptor blocking properties, and many showed a surprising degree of potency and beta 1-cardioselectivity when tested in vivo in anesthetized cats. The structure-activity relationships shown by this series of compounds are discussed and related to known beta-adrenergic

  描述了1-苯基-2-[[（取代的酰胺基烷基）氨基]氨基]乙醇的一系列衍生物的合成。研究了这些化合物的β-肾上腺素受体阻断特性，当在麻醉的猫体内进行测试时，许多化合物显示出令人惊讶的效力和β1-心脏选择性。讨论了这一系列化合物显示的结构活性关系，并与已知的β-肾上腺素能阻断剂有关。
• Substituted piperidines and methods of use
  申请人：——

  公开号：US20040006067A1

  公开（公告）日：2004-01-08

  Selected substituted piperidine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的替代哌啶化合物对预防和治疗疾病，如肥胖等，具有有效性。该发明涵盖了新颖化合物、类似物、前药和其药用可接受盐，以及用于预防和治疗涉及黑素皮质素受体激活的疾病和其他疾病或病症的药物组合物和方法。该发明还涉及制备此类化合物的方法，以及在此类方法中有用的中间体。
• Substituted piperazines and methods of use
  申请人：——

  公开号：US20030220324A1

  公开（公告）日：2003-11-27

  Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选择的替代哌嗪化合物对于预防和治疗疾病，如肥胖等，具有有效性。该发明涵盖了新型化合物、类似物、前药和其药用盐，以及用于预防和治疗涉及黑素皮质素受体激活的疾病和其他疾病或病症的药物组合物和方法。该发明还涉及制备这类化合物的方法，以及在这些过程中有用的中间体。
• [EN] SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR<br/>[FR] PIPERAZINES SUBSTITUEES COMME MODULATEURS DU RECEPTEUR DE MELANOCORTINE
  申请人：AMGEN INC

  公开号：WO2003009850A1

  公开（公告）日：2003-02-06

  Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes For making such compounds as well as to intermediates useful in such processes.

  选定的取代哌嗪化合物可用于预防和治疗疾病，如肥胖症等。该发明涵盖了新化合物、类似物、前药及其药学上可接受的盐、制药组合物以及用于预防和治疗涉及黑色素皮质素受体激活的疾病和其他疾病或病症的方法。该发明还涉及制造这些化合物的过程，以及在此类过程中有用的中间体。
• Reagents for directed biomarker signal amplification
  申请人：SIRIGEN II LIMITED

  公开号：US10962546B2

  公开（公告）日：2021-03-30

  Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

  本文描述的是涉及中性共轭聚合物的方法、组合物和制造品，包括合成中性共轭水溶性聚合物的方法，该聚合物沿聚合物主链结构具有连接体和末端封端单元。这种聚合物可用于制造新型光电器件和开发高效生物传感器。本发明还涉及这些聚合物在检测方法中的应用。