2-docosyloxy-9-(4-chlorophenyl)-9-bromofluorene | 1245574-82-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-docosyloxy-9-(4-chlorophenyl)-9-bromofluorene
• 英文别名: 9-bromo-9-(4-chlorophenyl)-2-docosoxyfluorene
• CAS: 1245574-82-6
• 化学式: C₄₁H₅₆BrClO
• 分子量: 680.252
• InChiKey: JCJJDSZORVZTRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17
• 重原子数：
  44
• 可旋转键数：
  23
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  L-丙氨酸 、 2-docosyloxy-9-(4-chlorophenyl)-9-bromofluorene 在 N,N-二异丙基乙胺 作用下， 以 氯仿 为溶剂， 以74%的产率得到
  参考文献：
  名称：

  EP2415744

  摘要：

  公开号：
• 作为产物：
  描述：

  1-溴二十二烷 在 乙酰溴 、 potassium carbonate 作用下， 以 四氢呋喃 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 2-docosyloxy-9-(4-chlorophenyl)-9-bromofluorene
  参考文献：
  名称：

  EP2415744

  摘要：

  公开号：

文献信息

• FLUORENE COMPOUND
  申请人：TAKAHASHI Daisuke

  公开号：US20100240867A1

  公开（公告）日：2010-09-23

  Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides.

  具有芴骨架的特定化合物在广泛的应用和稳定性方面优越，作为氨基酸和/或肽液相合成的保护试剂。
• Fluorene compound
  申请人：Takahashi Daisuke

  公开号：US08569453B2

  公开（公告）日：2013-10-29

  Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides.

  具有芴骨架的特定化合物在广泛的应用和稳定性方面表现出优越性，作为液相合成氨基酸和/或肽的保护试剂。
• METHOD FOR REMOVING FMOC GROUP
  申请人：Ajinomoto Co., Inc.

  公开号：US20140296483A1

  公开（公告）日：2014-10-02

  The present invention relates to a method of removing an Fmoc group, including a step of mixing a compound represented by the formula (I): HS-L-COOH  (I) wherein L is a C 1-8 alkylene group optionally having substituent(s), an amino group-containing compound protected by an Fmoc group, and a base to give a reaction mixture containing a compound represented by the formula (II): Fm-S-L-COOH  (II) wherein Fm is a 9-fluorenylmethyl group, and L is as mentioned above, and an amino group-containing compound, and a step of removing the compound represented by the formula (II) by washing the obtained reaction mixture with a basic aqueous solution. According to the present invention, a removal method of Fmoc group, which can remove a dibenzofulvene derivative as a byproduct with ease, can be provided.

  本发明涉及一种去除Fmoc基团的方法，包括混合式化合物（I）的步骤：HS-L-COOH（I），其中L是一个C1-8烷基链，可选地具有取代基，一种被Fmoc基团保护的氨基化合物和一种碱，以得到一种反应混合物，其中包含一种化合物，其由式（II）表示：Fm-S-L-COOH（II），其中Fm是9-芴甲基基团，L如上所述，还包括一种氨基化合物，以及通过用碱性水溶液洗涤所得到的反应混合物，去除由式（II）表示的化合物。根据本发明，可以提供一种可以轻松去除二苯并富烯衍生物作为副产物的Fmoc基团去除方法。
• METHOD FOR PRODUCING PEPTIDE CONTINUOUSLY
  申请人：AJINOMOTO CO., INC.

  公开号：US20220041648A1

  公开（公告）日：2022-02-10

  Peptides may be continuously produced by a method including the following steps (1), (A), (2), and (B): (1) performing a condensation reaction in a flow reactor to obtain an N-protected C-protected peptide in which an N-terminal amino group and C-terminal are protected by protecting groups, a side chain functional group is optionally further protected by a protecting group, and at least one of the C-terminal or the side chain functional group is protected by a pseudo-solid-phase protecting group (N-protected C-protected peptide), (A) washing a reaction mixture containing an N-protected C-protected peptide in a flow reactor and separating oil and water to separate an organic layer containing the N-protected C-protected peptide, (2) subjecting an organic layer containing an N-protected C-protected peptide to a reaction to remove a protecting group of an N-terminal amino group in a flow reactor to obtain a C-protected peptide in which an N-terminal amino group is not protected, C-terminal is protected by a protecting group, a side chain functional group is optionally further protected by a protecting group, and at least one of the C-terminal or the side chain functional group is protected by a pseudo-solid-phase protecting group (N-unprotected C-protected peptide), (B) subjecting a reaction mixture containing an N-unprotected C-protected peptide to washing and oil-water separation in a flow reactor to separate an organic layer containing the N-unprotected C-protected peptide.
• US8569453B2
  申请人：——

  公开号：US8569453B2

  公开（公告）日：2013-10-29