3-methoxy-N,N-bis(pyridin-2-ylmethyl)propan-1-amine | 742060-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-methoxy-N,N-bis(pyridin-2-ylmethyl)propan-1-amine
• CAS: 742060-16-8
• 化学式: C₁₆H₂₁N₃O
• 分子量: 271.362
• InChiKey: SBIWSHLNFWGRPR-UHFFFAOYSA-N

物化性质

• 沸点：
  372.3±37.0 °C(Predicted)
• 密度：
  1.089±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-methoxy-N,N-bis(pyridin-2-ylmethyl)propan-1-amine 、 zinc(II) chloride 以 甲醇 为溶剂， 以73%的产率得到(N-(2-methoxypropyl)-N,N-bis(2-pyridylmethyl)amine)dichlorozinc(II)
  参考文献：
  名称：

  Intramolecular ether oxygen coordination in the zinc complexes with dipicolylamine (DPA)-derived ligands

  摘要：

  The ether oxygen coordination to the zinc center in the complexes with dipicolylamine (DPA)-derived ligands, N-(2-methoxyethyl)-N, N-bis(2-pyridylmethyl) amine (L), N-(3-methoxypropyl)-N, N-bis(2-pyridylmethyl) amine (L'), and N-{3-(2-pyridylmethyloxy)propyl}-N, N-bis(2-pyridylmethyl) amine (L-Py) has been discussed. Upon chelation of the oxygen atom, L forms a five-membered chelate ring with respect to the 2-aminoethyl ether moiety whereas L' forms a six-membered chelate in 3-aminopropyl ether unit. This difference was highlighted by the crystal structures of ZnCl2 complexes, in which [Zn(L)Cl-2] (1) exhibited ether oxygen coordination but [Zn(L')Cl-2] (2) had the ether oxygen non-coordinated. The terminal pyridyl group of L-Py facilitates the ether oxygen atom coordination via a metal binding from the basal plane trans to the aliphatic nitrogen. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.02.022
• 作为产物：
  描述：

  2-氯甲基吡啶 、 3-甲氧基丙胺 在 potassium hydroxide 作用下， 以 水 为溶剂， 反应 100.0h， 生成 3-methoxy-N,N-bis(pyridin-2-ylmethyl)propan-1-amine
  参考文献：
  名称：

  含有 N,N-二(2-吡啶甲基)胺基配体的新型钴 (II) 配合物；甲基丙烯酸甲酯聚合的合成、表征和应用

  摘要：

  摘要 [CoCl2·6H2O]与N'-取代的N,N-二(2-甲基吡啶)胺配体如1-环己基-N,N-双(吡啶-2-基甲基)甲胺(LA)、2 -甲氧基-N,N-双(吡啶-2-基甲基)乙-1-胺(LB)和3-甲氧基-N,N-双(吡啶-2-基甲基)丙-1-胺(LC)，分别产生 [LnCoCl2]（Ln = LA、LB 和 LC）。[LnCoCl2] 中的 Co(II) 中心（Ln = LA，和 LC）通过将二（2-吡啶甲基）胺部分的氮原子与 Co（II）中心以及两个氯配体配位而采用扭曲的双锥几何结构。6-配位的 [LBCoCl2] 显示出扭曲的八面体几何形状，这是通过两个吡啶基单元、两个氯单元以及 N'-甲氧基乙胺中氮和氧的双齿配位与 Co(II) 中心的配位实现的。[LCCoCl2] (6. 与其他 Co(II) 配合物相比，70 × 104 gPMMA/molCo h) 在改性甲基铝氧烷 (MMAO)

  DOI：

  10.1016/j.molstruc.2016.02.022

文献信息

• Cycloneophylpalladium(IV) Complexes: Formation by Oxidative Addition and Selectivity of Their Reductive Elimination Reactions
  作者：Ava Behnia、Mahmood A. Fard、Johanna M. Blacquiere、Richard J. Puddephatt

  DOI：10.1021/acs.organomet.0c00615

  日期：2020.11.23

  formed via either CH2–Ar or CH2–X bond formation. In the latter case, neophyl rearrangement and protonolysis steps follow reductive elimination to give a mixture of organic products. The methylpalladium(IV) complexes [PdMe(CH2CMe2C6H4)(κ3-N,N′,N″-L)]I decompose at 0 °C by selective reductive elimination with Me–Ar bond coupling to give the alkylpalladium(II) complex [Pd(CH2CMe2-2-C6H4Me)(κ3-N,N′,N″-L)]I

  所述cycloneophylpalladium（II）配合物[加入Pd（CH 2 CME 2 ç 6 ħ 4）（κ 2 -N，N'-大号）]（大号= RO（CH 2）3 N（CH 2 -2-C 5 H ^ 4 N）2，R = H，Me）的经历氧化以钯（IV）与溴或碘，以得到[PDX（CH 2 CME 2 ç 6 ħ 4）（κ 3 -N，N'，N“ -大号）] X（X = Br，I）或与甲基碘一起制得瞬态络合物[PdMe（CH 2 CME 2 C 6ħ 4）（κ 3 -N，N'，N“ -大号）]我。BR的产品2和余2氧化，[PDX（CH 2 CME 2 ç 6 ħ 4）（κ 3 -N，N'，N“ -大号）] X（X = Br的，I），是足够稳定的，以被分离，但它们在溶液中缓慢地分解通过还原消除，得到钯（II）制品[PDX（κ 3 -N，N'，N“ -大号）] X（X = Br的，I）。通过CH
• [EN] COMPOUND HAVING ACTIVITY TO SUPPRESS DEGRANULATION AND CYTOKINE PRODUCTION AND USE THEREOF<br/>[FR] COMPOSÉ AYANT UNE ACTIVITÉ DE SUPPRESSION DE LA DÉGRANULATION ET DE PRODUCTION DE CYTOKINE, ET SON UTILISATION
  申请人：INTERPROTEIN CORP

  公开号：WO2009084737A1

  公开（公告）日：2009-07-09

  The present invention provides a compound represented by the formula (I): wherein L is an alkylene group;X is a bond, -O-, -S- or -CO-;Y is a bond, -NR3- or -CO-;Z is an organic group or OH;R1 and R2 are the same or different and each is an optionally substituted alkyl group, a halogen atom or a hydrogen atom; and R3 is an optionally substituted alkyl group or a hydrogen atom, or a salt thereof.

  本发明提供了一种由以下公式（I）表示的化合物：其中L是烷基链；X是键，-O-，-S-或-CO-；Y是键，-NR3-或-CO-；Z是有机基团或-OH；R1和R2相同或不同，每个都是可选择取代的烷基基团，卤素原子或氢原子；R3是可选择取代的烷基基团或氢原子，或其盐。
• Cadmium(II) complexes containing N′-substituted N,N-di(2-picolyl)amine: The formation of monomeric versus dimeric complexes is affected by the N′-substitution group on the amine moiety
  作者：Yujin Song、Saira Nayab、Jongho Jeon、Sang Hyun Park、Hyosun Lee

  DOI：10.1016/j.jorganchem.2015.02.011

  日期：2015.5

  6-coordinate dimeric [LACd(μ−Br)Br]2 and [LDCd(μ−Br)Br]2 showed a distorted octahedral geometry through coordination of nitrogen in the N′-substituted amine moiety (cyclohexylmethylamine and 3-methoxypropylamine, respectively) to the Cd metal centre and a bromide bridge ligand. However, the 5-coordinate monomeric [LBCdBr2] was square pyramidal through the coordination of nitrogen in the N′-phenyl-substituted

  [CdBr 2的反应。4H 2 O]与N' -取代的Ñ，ñ -二（2-吡啶甲基）胺配体，例如1-环己基- Ñ，ñ -双（吡啶-2-基甲基）甲胺（大号甲），Ñ，ñ -双（吡啶-2-基甲基）苯胺（大号乙），2-甲氧基ñ，ñ -双（吡啶-2-基甲基）乙-1-胺（大号ç）和3-甲氧基ñ，ñ -双（吡啶-2-基甲基）丙-1-胺（L D）在乙醇中生成镉（II）[Cd（II）]络合物，即[L n CdBr 2 ] m（L n  = L A，m = 2; L B，m = 1; L C，m = 1; L D，m = 2）。镉的分子结构（II）配合物显示，6-坐标二聚体[L甲镉（μ-溴）BR] 2和[L d镉（μ-溴）BR] 2呈扭曲的八面体几何形状通过在氮气协调的N'-取代的胺部分（分别为环己基甲胺和3-甲氧基丙胺）与Cd金属中心和溴化物桥配体的连接。然而，通过N'-苯基取代的胺残基中的氮与Cd金属中心的配位，五配位单体[L
• Control of Intramolecular Ether‐Oxygen Coordination in the Crystal Structure of Copper(II) Complexes With Dipicolylamine‐Based Ligands
  作者：Yuji Mikata、Tomomi Fujimoto、Yuko Sugai、Shigenobu Yano

  DOI：10.1002/ejic.200600801

  日期：2007.3

  Thirteen crystal structures of copper(II) complexes with a series of dipicolylamine (DPA)-derived ligands, N-(2-methoxyethyl)-N,N-bis(2-pyridylmethyl)amine (L1), N-[2-(2-hydroxyethyloxy)ethyl]-N,N-bis(2-pyridylmethyl)amine (L2) and N-(3-methoxypropyl)-N,N-bis(2-pyridylmethyl)amine (L3), have been determined and the factors that control the coordination of the ether-oxygen atom of these ligands to the

  铜 (II) 与一系列二吡啶甲胺 (DPA) 衍生配体、N-(2-甲氧基乙基)-N,N-双(2-吡啶基甲基)胺 (L1)、N-[2-( 2-羟基乙氧基）乙基]-N,N-双（2-吡啶基甲基）胺（L2）和N-（3-甲氧基丙基）-N,N-双（2-吡啶基甲基）胺（L3）讨论了控制这些配体的醚-氧原子与铜中心配位的因素。具有 +1 或 +2 电荷的配合物表现出醚-氧原子的配位，而两个阴离子与铜 (II) 中心结合的中性配合物往往会失去氧配位。与氧原子螯合后，L3 与 3-氨基丙基醚部分形成六元螯合环，而 L1 和 L2 形成五元螯合物。这种差异，尤其是在硝酸盐和溴化物络合物中，决定了醚-氧原子是螯合到金属中心形成单阳离子络合物，还是第二个阴离子与金属中心配位形成无醚的中性络合物。L2 的末端锚定羟基通过氢键相互作用促进醚-氧配位，供体原子位于基平面中与脂肪族氮原子反式。(© Wiley-VCH Verlag
• Manganese(II) complexes of a set of 2-aminomethylpyridine-derived ligands bearing a methoxyalkyl arm: syntheses, structures and magnetism
  作者：Jian-Zhong Wu、Elisabeth Bouwman、Allison M. Mills、Anthony L. Spek、Jan Reedijk

  DOI：10.1016/j.ica.2004.02.001

  日期：2004.7

  Four new ligands, N-(2-methoxyethyl)-N-(pyridin-2-ylmethyl)amine (mepma), N-(3-methoxypropyl)-N,N-bis(pyridin-2-ylmethyl)amine (mpbpa), N-(2-methoxyethyl)-N,N-bis(pyridin-2-ylmethyl)amine (mebpa) and 2-[(2-methoxyethyl)(pyridin-2-ylmethyl)amino]methyl} phenol (Hmepap), and four of their complexes with manganese(II) halides, [MnCl2(mepma)(2)] (1), [MnCl(g-Cl)(mpbpa)](2) (2), [MnBr2(mebpa)] (3) and [MnBr2(MeOH)(Hmepap)] (4) have been synthesized and characterized. Single-crystal Xray studies revealed that in all four complexes, the Mn(II) coordination spheres are distorted octahedral. In 1 and 2, the ether oxygen atom does not coordinate to the Mn(II) centre, but in 3 and 4 it does. The mononuclear molecules of I are linked by double hydrogen bonds to form linear chains. Temperature dependent magnetic susceptibility measurements revealed that the Mn(II) ions in 1 interact antiferromagnetically, with J = -1.06 cm(-1). Compound 2 crystallizes as a double chloride-bridged dimer in which there is a weak ferromagnetic interaction (J = 0.55 cm(-1)) between the Mn(II) pair. The solution EPR spectrum of 2 suggests that in methanol compound 2 decomposes to a great extent to mononuclear species. In compound 3, mebpa acts as a tetradentate ligand with all of its nitrogen and oxygen atoms coordinated to the Mn(II) ion. Unexpectedly, in complex 4, the phenolic oxygen of Hmepap remains protonated and does not coordinate to the metal ion. Instead the oxygen from a methanol molecule coordinates the manganese centre. Hydrogen bonds between one of the two bromide ions, and the methanol and phenol hydroxyl groups, respectively, connect the mononuclear molecules of 4 into chains. No magnetic interactions were observed between the Mn(II) ions in 3 or 4. (C) 2004 Elsevier B.V. All rights reserved.