6-(4-羟基-6-甲氧基-7-甲基-3-氧代-5-邻苯二甲酰基)-4-甲基-4-己烯酸三乙胺盐 | 66341-85-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 中文名称: 6-(4-羟基-6-甲氧基-7-甲基-3-氧代-5-邻苯二甲酰基)-4-甲基-4-己烯酸三乙胺盐
• 英文名称: triethylamine mycophenolate
• 英文别名: 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid triethylamine salt；mycophenolic acid triethylamine salt；mycophenolic acid triethylamine；Mycophenolate triethylamine；N,N-diethylethanamine;(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
• CAS: 66341-85-3
• 化学式: C₆H₁₅N*C₁₇H₂₀O₆
• 分子量: 421.534
• InChiKey: UCVFIGBNEJKUIA-JOKMOOFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.08
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  96.3
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6-(4-羟基-6-甲氧基-7-甲基-3-氧代-5-邻苯二甲酰基)-4-甲基-4-己烯酸三乙胺盐 在 sodium ethyl hexanoate 作用下， 以 乙酸乙酯 为溶剂， 反应 3.0h， 生成 sodium mycophenolate
  参考文献：
  名称：

  [EN] ISOLATION AND USE OF AMINE SALTS OF MYCOPHENOLIC ACID
  [FR] ISOLATION ET UTILISATION DE SELS AMINÉS D'ACIDE MYCOPHÉNOLIQUE

  摘要：

  公开号：

  WO2008003637A3
• 作为产物：
  描述：

  霉酚酸 、 三乙胺 以 乙酸乙酯 为溶剂， 反应 0.5h， 生成 6-(4-羟基-6-甲氧基-7-甲基-3-氧代-5-邻苯二甲酰基)-4-甲基-4-己烯酸三乙胺盐
  参考文献：
  名称：

  [EN] IMPROVED PROCESS FOR PREPARING MYCOPHENOLATE MOFETIL
  [FR] PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DE MYCOPHÉNOLATE DE MOFETIL

  摘要：

  公开号：

  WO2009096668A3

文献信息

• [EN] METHOD FOR THE PREPARATION OF MYCOPHENOLATE MOFETIL<br/>[FR] PROCÉDÉ DE PRÉPARATION DE MYCOPHÉNOLATE MOFÉTIL
  申请人：DSM IP ASSETS BV

  公开号：WO2009003878A1

  公开（公告）日：2009-01-08

  The present invention provides a method for the preparation of mycophenolate mofetil wherein mycophenolic acid or an amine salt of mycophenolic acid is esterified with 2-morpholinoethanol followed by downstream processing in the presence of a chelating agent (formula (I)).

  本发明提供了一种制备麦考酚酯酰甲酸酯的方法，其中麦考酚酸或麦考酚酸的胺盐与2-吗啉乙醇酯化，然后在螯合剂（式（I））存在下进行下游处理。
• PROCESS FOR PREPARING MYCOPHENOLATE MOFETIL
  申请人：Choi Byoung Taek

  公开号：US20100298560A1

  公开（公告）日：2010-11-25

  The present invention relates to an improved method of manufacturing mycophenolate mofetil. More particularly, the present invention relates to a method of manufacturing mycophenolate mofetil with high purity comprising : a) converting mycophenolate to an amine salt by reacting with an amine base; and b) reacting the resultant with a halogenating agent and 2-morpholinoethanol continuously.
• [EN] FORMULATIONS AND METHOD FOR TREATMENT OF INFLAMMATORY DISEASES<br/>[FR] FORMULATIONS ET MÉTHODE POUR LE TRAITEMENT DES MALADIES INFLAMMATOIRES
  申请人：VYOME THERAPEUTICS INC

  公开号：WO2021124301A1

  公开（公告）日：2021-06-24

  The present invention relates to formulations and their use to treat ocular disorders such as uveitis. Particularly, the invention relates to a formulation comprising mycophenolic acid (MPA) or a pharmaceutically acceptable salt or derivative thereof; and at least one component selected from the group consisting of preservative, chelating agent, buffering agent, pH modifier, thickening agent, viscosity enhancer or viscosity modifier, antioxidant, tonicity modifier, surfactant, humectant, solvent or co-solvent, emulsifier, co-emulsifier, ointment base, targeting agent, polymer, wetting agent, lubricating agent, suspending agent, and therapeutic agent. The disclosure further provides preparation method of said ophthalmic formulations, a pharmaceutical kit comprising said formulations, and method for treating ocular diseases by administering said formulations. The present formulations are advantageous and can be delivered to the eye with increased retention time in the eye and increased bioavailability of mycophenolic acid, or a pharmaceutically acceptable salt or derivative thereof in the eye.
• [EN] IMPROVED PROCESS FOR PREPARING MYCOPHENOLATE MOFETIL<br/>[FR] PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DE MYCOPHÉNOLATE DE MOFETIL
  申请人：CKD BIO CORP

  公开号：WO2009096668A3

  公开（公告）日：2010-05-27
• [EN] ISOLATION AND USE OF AMINE SALTS OF MYCOPHENOLIC ACID<br/>[FR] ISOLATION ET UTILISATION DE SELS AMINÉS D'ACIDE MYCOPHÉNOLIQUE
  申请人：DSM IP ASSETS BV

  公开号：WO2008003637A3

  公开（公告）日：2008-05-08