3-azido-1-propanamine hydrochloride

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 3-azido-1-propanamine hydrochloride
• 英文别名: 3-azidopropan-1-amine hydrochloride；3-azidopropylamine hydrochloride；3-Azido-1-propanamine hydrochloride；3-azidopropylazanium;chloride
• 化学式: C₃H₈N₄*ClH
• 分子量: 136.584
• InChiKey: XZFJZGIGUCXZKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.07
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-azido-1-propanamine hydrochloride 在 potassium hydroxide 作用下， 以 二氯甲烷 为溶剂， 以1.2 g的产率得到3-叠氮基丙胺
  参考文献：
  名称：

  Synthesis and Hierarchical Self-Assembly of Rod−Rod Block Copolymers via Click Chemistry between Mesogen-Jacketed Liquid Crystalline Polymers and Helical Polypeptides

  摘要：

  A series of novel rod-rod diblock copolymers containing poly{2,5-bis[(4-methoxyphenyl)oxycarbonyl]styrene} (PMPCS) and poly(gamma-benzyl-L-glutamate) (PBLG) were synthesized by click chemistry from alkyne- and azide-functionalized homopolymers The alpha-alkyne PM PCS homopolymers were synthesized by coppei -mediated atom ti ansfer radical polymerization with a In online-containing a-alkyne bifun( tional initiator, and a-azido PBLG homopolymers were synthesized by ring-opening polymerization of gamma-benzyl-L-glutamate N-car boxyanhydnde with an amino-containing a-azide mina tor The no struceares of the rod-rod block copcdymeis were confirmed by H-1 NM R spectroscopy, Fourier transform int) an.rd spectroscopy, and gel permeation chromatography analysis The self-assembling behavior of the rod t od block copolymers in bulk was investigated using differential scanning calonmetry, polar Ind light micro;copy, wide-angle X-ray diffraction, and transmission electron microscopy techniques A lamellar structure was observed with of f(PBLG) similar to 0 50, in which PMPCS was in a columnar nematie phase and PBLG assigned to a hexagonally packed-cylinder structure (Phi(II)) According to the TEM micrographs and simulated lengths of the copolymers. a stacked bdayei structure in a hexagon in lamella morphology for the selfassembly of the rod rod block copolymers was proposed Finally, by increasing f(PBLG) to similar to 0 69, a micro?hase-sepat riled hexagon in cylinder morphology was found, in which PM PCS formed the core of the cylinders sur rounded by PBLG in Phi(II) phase and both rods were in an inter digitated packing

  DOI：

  10.1021/ma1007418
• 作为产物：
  描述：

  3-溴丙胺氢溴酸盐 在 sodium azide 、 盐酸 作用下， 以 水 为溶剂， 以55%的产率得到3-azido-1-propanamine hydrochloride
  参考文献：
  名称：

  通过原位点击化学选择性 RNA 与 DNA G-四链体靶向

  摘要：

  一切都按部就班：通过使用由非沃森-克里克 DNA 二级结构催化的一系列炔烃和叠氮化物构件的无铜 1,3-偶极环加成，已经鉴定出一种有效的端粒靶向小分子（参见图片）。这种方法可以快速识别出意想不到的有效小分子探针，以选择性地靶向给定的 RNA 或 DNA。

  DOI：

  10.1002/anie.201206281
• 作为试剂：
  描述：

  1-azido-2-(2-(2-(2-[¹⁸F]fluoroethoxy)ethoxy)ethoxy)ethane 、 在 copper(II) sulfate 、 sodium ascorbate 、 4-羟乙基哌嗪乙磺酸 、 3-azido-1-propanamine hydrochloride 作用下， 以 四氢呋喃 、 二甲基亚砜 、 乙腈 为溶剂， 反应 0.33h， 生成
  参考文献：
  名称：

  用半胱天冬酶触发的纳米聚集探针对药物诱导的肿瘤细胞凋亡进行正电子发射断层扫描成像

  摘要：

  药物设计：制备并评估了18 F 标记的 caspase-3 敏感纳米聚集正电子发射断层扫描示踪剂，用于对阿霉素处理的肿瘤异种移植物中的 caspase-3 活性进行成像。通过分子内大环化和 caspase-3 激活后的原位聚集来增强18 F 活性在凋亡肿瘤中的保留（见图）。

  DOI：

  10.1002/anie.201303422

文献信息

• IRAK DEGRADERS AND USES THEREOF
  申请人：Kymera Therapeutics, Inc.

  公开号：US20190192668A1

  公开（公告）日：2019-06-27

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用这些化合物的方法。
• [EN] COMPOSITIONS AND METHODS RELATED TO ANTI-CD19 ANTIBODY DRUG CONJUGATES<br/>[FR] COMPOSITIONS ET MÉTHODES ASSOCIÉES À DES CONJUGUÉS ANTICORPS ANTI-CD19-MÉDICAMENTS
  申请人：LEGOCHEM BIOSCIENCES INC

  公开号：WO2017051249A1

  公开（公告）日：2017-03-30

  In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-CD 19 antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.

  在某些方面，本发明涉及一种抗体药物偶联物，包括：一种抗CD19抗体；一个连接器；和一个活性剂。抗体药物偶联物可以包括一个自焚基团。连接器可以包括一个O-取代的肟，例如，肟的氧原子被一个与活性剂共价连接的基团所取代；肟的碳原子被一个与抗体共价连接的基团所取代。
• [EN] COMPOSITIONS AND METHODS RELATED TO ANTI-EGFR ANTIBODY DRUG CONJUGATES<br/>[FR] COMPOSITIONS ET MÉTHODES ASSOCIÉES À DES CONJUGUÉS ANTICORPS ANTI-EGFR-MÉDICAMENTS
  申请人：LEGOCHEM BIOSCIENCES INC

  公开号：WO2017051254A1

  公开（公告）日：2017-03-30

  In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-epidermal growth factor receptor ("EGFR") antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the drug; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.

  在某些方面，本发明涉及一种抗体-药物偶联物，包括针对表皮生长因子受体（“EGFR”）的抗体；连接体；以及活性剂。抗体-药物偶联物可以包含自焚基团。连接体可以包含O-取代的肟，例如，其中肟的氧原子被取代以与药物共价连接的基团；肟的碳原子被取代以与抗体共价连接的基团。
• Benzoazine mono-N-oxides and benzoazine 1,4 dioxides and compositions therefrom for the therapeutic use in cancer treatments
  申请人：Auckland Uniservices Limited

  公开号：EP1468688A2

  公开（公告）日：2004-10-20

  The present invention relates to a synergetistic composition comprising one or more benzoazine-mono-N-oxides, and one or more benzoazine 1,4 dioxides for use in cancer therapy. The invention also provides a range of novel 1,2,4 benzoazine-mono-N-oxides and related analogues. These can be used as potentiators of the cytotoxicity of existing anticancer drugs and therapies for cancer treatment.

  本发明涉及一种协同组合物，包括一种或多种苯并噁唑-单-N-氧化物，以及一种或多种苯并噁唑1,4-二氧化物，用于癌症治疗。 该发明还提供了一系列新颖的1,2,4苯并噁唑-单-N-氧化物及相关类似物。这些可以用作增强现有抗癌药物的细胞毒性和癌症治疗的治疗剂。
• Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions
  作者：Anna Barnard、Kérya Long、Heather L. Martin、Jennifer A. Miles、Thomas A. Edwards、Darren C. Tomlinson、Andrew Macdonald、Andrew J. Wilson

  DOI：10.1002/anie.201410810

  日期：2015.3.2

  discovery. α‐Helix mediated PPIs may be amenable to modulation using generic chemotypes, termed “proteomimetics”, which can be assembled in a modular manner to reproduce the vectoral presentation of key side chains found on a helical motif from one partner within the PPI. In this work, it is demonstrated that by using a library of N‐alkylated aromatic oligoamide helix mimetics, potent helix mimetics which

  抑制蛋白质-蛋白质相互作用 (PPI) 是化学生物学和药物发现的主要挑战。α-螺旋介导的 PPI 可能适合使用称为“蛋白质模拟物”的通用化学型进行调节，该化学型可以以模块化方式组装，以重现 PPI 内一个伙伴在螺旋基序上发现的关键侧链的矢量呈现。在这项工作中，证明通过使用 N-烷基化芳族寡酰胺螺旋模拟物库，可以识别在细胞环境中重现其生物物理结合选择性的有效螺旋模拟物。