Na-EDTA | 17421-79-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Na-EDTA
• 英文别名: Monosodium ethylenediaminetetraacetate；sodium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate
• CAS: 17421-79-3
• 化学式: C₁₀H₁₅N₂O₈*Na
• 分子量: 314.227
• InChiKey: HLWRUJAIJJEZDL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -6.4
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  159
• 氢给体数：
  3
• 氢受体数：
  10

安全信息

• 海关编码：
  2922509090

反应信息

• 作为反应物：
  描述：

  乙酸铁(III) 、 Na-EDTA 生成 乙二胺四乙酸铁钠
  参考文献：
  名称：

  RATAJEWICZ, ZBIGNIEW;SAWA, JOZEF

  摘要：

  DOI：
• 作为产物：
  描述：

  乙二胺四乙酸 在 sodium hydroxide 、 碳酸氢钠 作用下， 以 水 为溶剂， 生成 Na-EDTA
  参考文献：
  名称：

  Synthesis and vibrational study of some polydentate ligands

  摘要：

  DOI：

  10.1016/0584-8539(87)80176-9
• 作为试剂：
  描述：

  lipitor 在 Na-EDTA 作用下， 以 水 为溶剂， 生成 阿托伐他汀
  参考文献：
  名称：

  WO2007/4236

  摘要：

  公开号：

文献信息

• Hiv Integrase Inhibitors
  申请人：Wai John S.

  公开号：US20080287394A1

  公开（公告）日：2008-11-20

  Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

  羟基取代的吡嗪吡咯吡啶二酮化合物是HIV整合酶的抑制剂和HIV复制的抑制剂。在一种实施例中，二酮化合物是公式（I）中的化合物，其中R1，R2，R3，R4，R5，R6和R7在此被定义。这些化合物对于预防和治疗HIV感染以及预防、延缓和治疗艾滋病非常有用。这些化合物作为化合物本身或作为药物可接受的盐的形式用于对抗HIV感染和艾滋病。这些化合物及其盐可以作为药物组成部分使用，可选地与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用。
• AMINOCARBOXYLATE POWDERS WITH IMPROVED PURITY AND FLOWABILITY PROPERTIES
  申请人：Moore, JR. J. W.

  公开号：US20110288332A1

  公开（公告）日：2011-11-24

  Provided is a method for preparing stable free flowing solid aminocarboxylate chelants by adding to a chelant that contains residual alkaline metal hydroxide a free or partially neutralized carboxylic acid such that the free or partially neutralized acid neutralizes at least a portion of the alkaline metal hydroxide; and isolating therefrom the free-flowing solid chelant.

  提供了一种制备稳定自由流动的固态氨基羧酸螯合剂的方法，该方法是向含有残留碱性金属氢氧化物的螯合剂中添加一个自由或部分中和的羧酸，使得自由或部分中和的酸至少中和部分碱性金属氢氧化物；然后从中分离出自由流动的固态螯合剂。
• Lanthanum-based coordination polymers microplates using a “green ligand” EDTA with tailorable morphology and fluorescent property
  作者：Zhurui Shen、Sisi He、Pengcheng Yao、Xun Lao、Bin Yang、Yejing Dai、Xiaohong Sun、Tiehong Chen

  DOI：10.1039/c3ra46829a

  日期：——

  In this work, lanthanum (La)-based coordination polymers (CPs) microplates were fabricated in a simple bottom-up way by hydrothermal reaction of La3+ and a “green ligand” EDTA (ethylenediamine-N,N,N′,N′-tetraacetate). Under similar conditions, cerium (Ce)–EDTA CPs microplates could also be fabricated, which had the same crystalline phase and similar chemical composition to the La–EDTA CPs. The formation mechanism of the La–EDTA CPs was investigated and proved to follow the Ostwald ripening process. Moreover, its morphology could be tuned facilely by varying the quantity of EDTA and the total concentrations of reactants, and several kinds of micro/nanostructures were produced such as nanoparticle clusters, nanofibers, large or uniform microplates. Furthermore, the as-prepared La–EDTA CPs exhibited green light emission property after doping with Tb3+, and La2O3 nanorods as well as CeO2 microplates were also prepared by calcination of their corresponding CPs precursors.

  在这项研究中，通过La3+与 "绿色配体 "EDTA（乙二胺-N,N,N²,N²-四乙酸酯）的水热反应，以自下而上的简单方法制备了基于镧（La）的配位聚合物（CPs）微板。在类似条件下，还可以制备铈（Ce）âEDTA CPs 微板，与 LaâEDTA CPs 具有相同的结晶相和相似的化学成分。对 LaâEDTA CPs 的形成机理进行了研究，证明其遵循奥斯特瓦尔德熟化过程。此外，通过改变乙二胺四乙酸（EDTA）的用量和反应物的总浓度，可以方便地调整其形态，并制备出多种微/纳米结构，如纳米颗粒团、纳米纤维、大型或均匀的微板。此外，制备的 LaâEDTA 氯化石蜡在掺杂 Tb3+ 后具有绿光发射特性，通过煅烧相应的氯化石蜡前驱体还制备了 La2O3 纳米棒和 CeO2 微板。
• Immunodiagnostic assays for use in the detection and determination of mastitis
  申请人：UNIVERSITY COLLEGE DUBLIN

  公开号：EP0375424A1

  公开（公告）日：1990-06-27

  Immunodiagnostic assays for the detection and determination of mastitis and sub-clinical mastitis comprise capturing neutrophils or fragments or soluble products thereof in a milk sample on an insolubilised form of a corresponding antibody, optionally using conditions whereby the cells in the milk sample are lysed. Monoclonal antibodies are provided which can be used in said assays and which are specific to neutrophils.

  用于检测和确定乳腺炎和亚临床乳腺炎的免疫诊断测定包括将牛奶样品中的中性粒细胞或其片段或可溶性产物捕捉到相应抗体的未溶解形式上，可选择使用牛奶样品中的细胞被裂解的条件。所提供的单克隆抗体可用于上述检测，且对中性粒细胞具有特异性。
• Pan paint compostion
  申请人：BINNEY & SMITH INC.

  公开号：EP0705887A2

  公开（公告）日：1996-04-10

  Pan paints and associated color-changing systems are disclosed. In a first embodiment, the color-changing system comprises an undercolor pan paint coloring composition comprising an undercolor dye whose coloring ability is destroyed in the presence of a pH of about 10 or greater and / or in the presence of a reducing agent; and an overcolor composition comprising a colorant capable of maintaining its characteristic color in the presence of a pH of about 10 or greater and / or in the presence of a reducing agent, and a base such that the pH of the overcolor composition is about 10 or greater and / or a reducing agent. In a second embodiment, the color-changing system comprises an undercolor coloring composition comprising an undercolor dye whose coloring ability is destroyed in the presence of a pH of about 4 or less; and an overcolor coloring composition comprising a colorant capable of maintaining its characteristic color in the presence of a pH of about 4 or less and an acid such that the pH of the overcolor coloring composition is about 4 or less; wherein one or both of the coloring compositions is a pan paint.

  本发明公开了平底锅涂料和相关的变色系统。在第一个实施方案中，变色系统包括底色泛用漆着色组合物，该组合物包含底色染料，其着色能力在 pH 值约为 10 或更高和/或存在还原剂的情况下被破坏；以及罩色组合物，该组合物包含在 pH 值约为 10 或更高和/或存在还原剂的情况下能够保持其特征颜色的着色剂，以及碱，使得罩色组合物的 pH 值约为 10 或更高和/或存在还原剂。在第二个实施方案中，变色系统包括一种底色着色组合物，该组合物包含一种底色染料，其着色能力在 pH 值约为 4 或更低的条件下被破坏；以及一种罩色着色组合物，该组合物包含一种着色剂，该着色剂能够在 pH 值约为 4 或更低的条件下保持其特征颜色，以及一种酸，使得罩色着色组合物的 pH 值约为 4 或更低；其中一种或两种着色组合物是一种泛色涂料。