2-溴-2-甲基丁酸乙酯 | 5398-71-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-溴-2-甲基丁酸乙酯
• 英文名称: ethyl 2-bromo-2-methylbutanoate
• 英文别名: 2-bromo-2-ethyl-2-methyl acetic acid ethyl ester
• CAS: 5398-71-0
• 化学式: C₇H₁₃BrO₂
• 分子量: 209.083
• InChiKey: ALHOFXQMBUWICK-UHFFFAOYSA-N

物化性质

• 沸点：
  181.6±8.0 °C(Predicted)
• 密度：
  1.300±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  2-溴-2-甲基丁酸乙酯 在 氢氧化钾 、 硫酸 作用下， 以 乙醇 、 苯 为溶剂， 生成 n-Propyl 2-methyl-2-[p-(p'-chlorobenzyl)phenoxy]butyrate
  参考文献：
  名称：

  Thiele; Ahmed; Jahn, Arzneimittel-Forschung/Drug Research, 1979, vol. 29, # 5, p. 711 - 720

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基丁酸乙酯 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 氯仿 为溶剂， 反应 3.0h， 以81%的产率得到2-溴-2-甲基丁酸乙酯
  参考文献：
  名称：

  [EN] SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS
  [FR] COMPOSÉS DE SULFONIMIDAMIDE EN TANT QUE MODULATEURS DE NLRP3

  摘要：

  本文描述了式(I)、式(I-A)和式(I-B)的化合物，以及它们的溶剂化物、互变异构体和上述化合物的药用可接受盐，此外，本文还描述了使用这些化合物抑制NLRP3的方法，以及用于治疗NLRP3依赖性疾病的方法和组合物。

  公开号：

  WO2021150574A1

文献信息

• Cholesterol-lowering phenoxyalkanoic acid esters
  申请人：Siegfried Aktiengesellschaft

  公开号：US04153803A1

  公开（公告）日：1979-05-08

  Compounds possessing pharmaceutical activity as substances able to lower the level of fatty substances in the blood possess the following general formula: ##STR1## wherein R represents hydrogen, halogen, hydroxy or alkyl or alkoxy containing from 1 to 4 carbon atoms; A.sup.1 and A.sup.2 which can be the same or different are hydrogen or alkyl containing from 1 to 9 carbon atoms such that A.sup.1 and A.sup.2 contain together not more than 10 carbon atoms, Y is oxygen, in which case X is benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is amine, azacyclohydrocarbyloxy cycloalkoxy containing from 3 to 6 ring carbon atoms or tertiary aminoalkoxy or pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, or X is hydrogen and Z is pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, or Y is oxygen, X is benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is alkoxy containing from 1 to 4 carbon atoms, hydroxy or O.sup.- M.sup.+, M being a metal cation of Main Groups I, II or III of the Periodic System of the Elements or an organic base cation or ammonium ion, A.sup.1 and A.sup.2 being the same and being as aforesaid or being different with one of A.sup.1 and A.sup.2 being hydrogen or both being hydrogen and X being a para substituent with respect to Y in the benzene ring in the same general formula, Y is oxygen, X is hydrogen and Z is amine, azacyclohydrocarbyloxy or pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, Or Y is sulphur, in which case X is hydrogen, benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is amine, azacyclohydrocarbyloxy, alkoxy containing from 1 to 4 carbon atoms, hydroxy, O.sup.- M.sup.+ wherein M is a metal cation of Main Groups I, II or III of the Periodic System of The Elements or an organic base cation or ammonium ion, cycloalkoxy containing from 3 to 6 ring carbon atoms or tertiaryaminoalkoxy, pivaloyloxyalkoxy or pyridyl-C-alkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, and pharmacologically acceptable acid addition and quaternary ammonium salts of compounds containing basic groups, and optical isomers of said compounds when A.sup.1 and A.sup.2 are different.

  具有降低血液中脂质含量能力的具有药用活性的化合物具有以下一般公式：##STR1## 其中R代表氢、卤素、羟基或含有1至4个碳原子的烷基或烷氧基；A.sup.1和A.sup.2可以相同也可以不同，分别代表含有1至9个碳原子的氢或烷基，使得A.sup.1和A.sup.2共同含有不超过10个碳原子，Y为氧，此时X为苄基、苄氧基或苄硫氧基或被R取代的苄基、苄氧基或苄硫氧基，Z为胺、含有3至6个环碳原子的氮代环烷氧基环烷氧基或三级氨基氧基或戊二酰氧基氧基，其中烷氧基含有1至3个碳原子，或X为氢而Z为戊二酰氧基氧基，其中烷氧基含有1至3个碳原子，或Y为氧，X为苄基、苄氧基或苄硫氧基或被R取代的苄基、苄氧基或苄硫氧基，Z为含有1至4个碳原子的烷氧基、羟基或O.sup.- M.sup.+，M为元素周期表主族I、II或III的金属阳离子或有机碱阳离子或铵离子，A.sup.1和A.sup.2相同且如上所述或不同，其中A.sup.1和A.sup.2中的一个为氢或两者均为氢且X为与苯环中Y相对的对位取代基，在相同的一般公式中，Y为氧，X为氢，Z为胺、氮代环烷氧基或戊二酰氧基氧基，其中烷氧基含有1至3个碳原子，或Y为硫，此时X为氢、苄基、苄氧基或苄硫氧基或被R取代的苄基、苄氧基或苄硫氧基，Z为胺、氮代环烷氧基、含有1至4个碳原子的烷氧基、羟基、O.sup.- M.sup.+，其中M为元素周期表主族I、II或III的金属阳离子或有机碱阳离子或铵离子，含有含有3至6个环碳原子的环烷氧基或三级氨基氧基、戊二酰氧基氧基或吡啶基-C-烷氧基，其中烷氧基含有1至3个碳原子，以及含有碱性基团的化合物的药理学上可接受的酸盐和季铵盐，以及当A.sup.1和A.sup.2不同时，所述化合物的光学异构体。
• Process for the production of living radical polymers and polymers
  申请人：Yamago Shigeru

  公开号：US20060135711A1

  公开（公告）日：2006-06-22

  A process for producing a living radical polymer characterized in that a vinyl monomer is polymerized with use of an organotellurium compound represented by the formula (1) and an azo type polymerization initiator, and the living radical polymer obtainable by the process wherein R 1 is C 1 -C 8 alkyl, aryl, substituted aryl or an aromatic heterocyclic group, R 2 and R 3 are each a hydrogen atom or C 1 -C 8 alkyl, and R 4 is aryl, substituted aryl, an aromatic heterocyclic group, acyl, oxycarbonyl or cyano.

  使用由公式（1）表示的有机碲化合物和偶氮类聚合引发剂聚合乙烯单体的生活自由基聚合物的生产方法，其中所述生活自由基聚合物可通过该方法获得 其中R1为C1-C8烷基，芳基，取代芳基或芳香杂环基，R2和R3分别为氢原子或C1-C8烷基，R4为芳基，取代芳基，芳香杂环基，酰基，氧羰基或氰基。
• ARYL COMPOUNDS AS PPAR LIGANDS AND THEIR USE
  申请人：Kang Heonjoong

  公开号：US20120271055A1

  公开（公告）日：2012-10-25

  The present invention relates to a compound as a peroxisome proliferator activated receptor (PPAR) activator and a hydrate, a solvate, a stereoisomer and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition, a cosmetic composition, a muscle strengthening agent, a memory improving agent, a therapeutic agent for dementia and Parkinson's disease, a functional food and a feed composition containing the same.

  本发明涉及一种作为过氧化物酶体增殖物激活受体（PPAR）激活剂的化合物及其水合物、溶剂化合物、立体异构体和药用可接受盐，以及含有该化合物的药物组合物、化妆品组合物、肌肉强化剂、记忆改善剂、治疗痴呆症和帕金森病的药物、功能性食品和含有该化合物的饲料组合物。
• Directed Copper-Catalyzed Intermolecular Heck-Type Reaction of Unactivated Olefins and Alkyl Halides
  作者：Chunlin Tang、Ran Zhang、Bo Zhu、Junkai Fu、Yi Deng、Li Tian、Wei Guan、Xihe Bi

  DOI：10.1021/jacs.8b10874

  日期：2018.12.12

  A new type of intermolecular alkylative olefination of unactivated olefins and alkyl halides has been realized for the first time. This copper-promoted Heck-type reaction employs a directing-group strategy to efficiently produce the coupled alkyl olefin products with excellent regio- and stereoselectivity. A broad substrate scope including 1°, 2°, and 3° alkyl bromides and various nonactivated alkenes

  首次实现了未活化烯烃和卤代烷的新型分子间烷基化烯化。这种铜促进的 Heck 型反应采用定向基团策略有效地生产具有优异区域和立体选择性的偶联烷基烯烃产物。可以很好地耐受广泛的底物范围，包括 1°、2° 和 3° 烷基溴化物和各种未活化的烯烃。DFT 计算揭示了二甲基亚砜辅助协调 H-Br 消除构象应变 Cu(III) 环状过渡态的过程。
• General and Facile Method for <i>exo</i>-Methlyene Synthesis via Regioselective C–C Double-Bond Formation Using a Copper–Amine Catalyst System
  作者：Takashi Nishikata、Kimiaki Nakamura、Kohei Itonaga、Shingo Ishikawa

  DOI：10.1021/ol502953w

  日期：2014.11.7

  elimination to produce exomethylene compounds with a newly formed Csp3–Csp3 bond between tertiary alkyl halides and α-alkylated styrenes, a combination of a Cu(I) salt and a pyridine-based amine ligand (TPMA) is found to be a very efficient catalyst system. The yields and regioselectivities were high, and the regioselectivity was found to be dependent on the structure of the alkyl halide, with bulky alkyl

  在这项研究中，为消除远端选择的β-氢化物以生成在叔烷基卤化物和α-烷基化苯乙烯之间具有新形成的Csp 3 -Csp 3键的外亚甲基化合物，需要结合使用Cu（I）盐和吡啶基发现胺配体（TPMA）是非常有效的催化剂体系。产率和区域选择性高，并且发现区域选择性取决于卤代烷的结构，大体积的卤代烷表现出最高的远端选择性。