12-oxo-3,4-seco-5β-cholane-3,4,24-trioic acid | 438-06-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-oxo-3,4-seco-5β-cholane-3,4,24-trioic acid
• 英文别名: 12-Oxo-3,4-seco-5β-cholan-3,4,24-trisaeure；Desoxybiliansaeure；(3R,3aR,5aS,6R,7S,9aR,9bS)-3-[(2R)-4-carboxybutan-2-yl]-6-(2-carboxyethyl)-3a,6-dimethyl-4-oxo-1,2,3,5,5a,7,8,9,9a,9b-decahydrocyclopenta[a]naphthalene-7-carboxylic acid
• CAS: 438-06-2
• 化学式: C₂₄H₃₆O₇
• 分子量: 436.546
• InChiKey: FCLKILCSSINPNA-IFGJHMKXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  12-oxo-3,4-seco-5β-cholane-3,4,24-trioic acid 在 重氮甲烷 、 乙醚 作用下， 生成 12-oxo-3,4-seco-5β-cholanetrioic acid-(3.4.24)-trimethyl ester
  参考文献：
  名称：

  Windaus; Bohne, Justus Liebigs Annalen der Chemie, 1925, vol. 442, p. 7,15

  摘要：

  DOI：
• 作为产物：
  描述：

  3,12-二氧代-5-beta-胆烷-24-酸 在 sodium hydroxide 、 potassium permanganate 作用下， 生成 12-oxo-3,4-seco-5β-cholane-3,4,24-trioic acid
  参考文献：
  名称：

  Lymphocyte subset pattern in acromegaly

  摘要：

  Immune function in acromegalic patients has been poorly investigated. The aim of this study was to evaluate the main surface antigen clusters of circulating lymphocytes in acromegaly. One hundred patients with active acromegaly (55 women and 45 men, aged 20-70 yr) and 200 healthy subjects sex- and age-matched with the patients (110 women and 90 men, aged 20-70 yr) were enrolled in this study. All patients and controls were born and live in Southern Italy. No patient had received octreotide, bromocriptine or corticosteroids for at least 3 months before entering the study. The analysis of lymphocyte subset pattern was performed by flow cytometry and fluorescein isothiocyanate or phycoerythrin directly conjugated monoclonal antibodies specific for the cell surface antigen clusters (CD) representing T-cell population as a whole (CD3), T helpers (CD4), T suppressors (CD8), natural killer cells (CD16) and B-cell population as a whole (CD19). Acromegalics had significantly increased levels of CD3 (67.1+/-7.2 vs 64.3+/-8.8%; p=0.03) and CD4 (37.8+/-3.5 vs 36.4+/-4.3%; p=0.004) and decreased levels of CD8 (31.4+/-3.3 vs 33.7+/-8.2%; p<0.01) and CD19 (12.1+/-3.1 vs 15.2+/-5.1; p=0.01) without age-difference. The results of the current study demonstrate an increase in T-cell activity together with a decrease in B-cell activity in a very large series of patients with active acromegaly. These data further support the existence of abnormalities of the immune system in patients with chronic GH/IGF-I excess. (C)2002, Editrice Kurtis.

  DOI：

  10.1007/bf03343975

文献信息

• Noninvasive drug delivery
  作者：Ruth Zimmer、Michael A. Ashburn

  DOI：10.1007/s12019-001-0027-z

  日期：2001.12

  Advances in biopharmaceutical technology have spawned new drug delivery devices and mechanisms. Noninvasive methods, including iontophoresis and transmucosal drug delivery, have improved treatment of certain patient population. Their use is discussed in the following paper.

  生物制药技术的进步催生了新的药物输送装置和机制。非侵入性的方法，包括离子透入法和粘膜药物输送，改善了对某些患者群体的治疗。它们的使用将在以下论文中讨论。
• Borsche; Hallwass, Chemische Berichte, 1922, vol. 55, p. 3318,3323
  作者：Borsche、Hallwass

  DOI：——

  日期：——
• Schenck, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1924, vol. 139, p. 39,46, 48
  作者：Schenck

  DOI：——

  日期：——
• Borsche, Chemische Berichte, 1924, vol. 57, p. 1435
  作者：Borsche

  DOI：——

  日期：——
• Wieland; Kraft, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1932, vol. 211, p. 203,206
  作者：Wieland、Kraft

  DOI：——

  日期：——