Pht-L-天冬酰胺 | 42406-52-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: Pht-L-天冬酰胺
• 中文别名: N-A-邻苯二酰-L-精氨酸
• 英文名称: N²,N²-phthaloyl-L-asparagine
• 英文别名: N²,N²-Phthaloyl-L-asparagin；2-Phthalimido-bernsteinsaeure-4-amid, N-Phthaloyl-asparagin；N²-Phthaloyl-L-asparagin；N-Phthaloyl-L-asparagin；N-Phthaloylasparagin；Phthalyl-L-asparagin；N-alpha-Phthalyl-L-Asparagine；(2S)-4-amino-2-(1,3-dioxoisoindol-2-yl)-4-oxobutanoic acid
• CAS: 42406-52-0
• 化学式: C₁₂H₁₀N₂O₅
• 分子量: 262.222
• InChiKey: FXHJNPKWNYXBKP-QMMMGPOBSA-N

物化性质

• 熔点：
  200-201 °C
• 沸点：
  576.1±45.0 °C(Predicted)
• 密度：
  1.573±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2925190090
• 储存条件：
  存储条件：密封、干燥、避光，温度范围为2-8°C。

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: N-Alpha-phthalyl-l-asparagine
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: N-Alpha-phthalyl-l-asparagine
CAS number: 42406-52-0

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C12H10N2O5
Molecular weight: 262.2

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  Pht-L-天冬酰胺 在 水 、 一水合肼 作用下， 生成 L-天冬酰胺
  参考文献：
  名称：

  661.由邻苯二甲酰亚胺酸合成。第三部分 由邻苯二甲酰-DL-和-L-天冬氨酸酐制备DL-和L-天冬酰胺

  摘要：

  DOI：

  10.1039/jr9510002976
• 作为产物：
  描述：

  N²-phthalyl-L-aspartic anhydride 在 1,4-二氧六环 、 乙醚 、 氨 作用下， 生成 Pht-L-天冬酰胺
  参考文献：
  名称：

  661.由邻苯二甲酰亚胺酸合成。第三部分 由邻苯二甲酰-DL-和-L-天冬氨酸酐制备DL-和L-天冬酰胺

  摘要：

  DOI：

  10.1039/jr9510002976

文献信息

• DETERGENT COMPOSITION COMPRISING A FATTY ACID-TRANSFORMING ENZYME
  申请人：The Procter & Gamble Company

  公开号：EP3243897A1

  公开（公告）日：2017-11-15

  Use of a detergent composition comprising a fatty acid-transforming enzyme to impart suds longevity in a washing process.

  使用含有脂肪酸转化酶的洗涤剂组合物，在洗涤过程中延长泡沫寿命。
• DETERGENT COMPOSITION COMPRISING A FATTY ACID DECARBOXYLASE
  申请人：The Procter & Gamble Company

  公开号：EP3243896A1

  公开（公告）日：2017-11-15

  A detergent composition, preferably a manual dishwashing detergent composition and method of washing comprising a surfactant system and a fatty acid decarboxylase enzyme.

  由表面活性剂体系和脂肪酸脱羧酶组成的洗涤剂组合物，最好是手动洗碗机洗涤剂组合物和洗涤方法。
• DETERGENT COMPOSITION
  申请人：The Procter & Gamble Company

  公开号：EP3269729A1

  公开（公告）日：2018-01-17

  A detergent composition comprising a BslA-like protein and a surfactant system

  由 BslA 样蛋白和表面活性剂系统组成的洗涤剂组合物
• DETERGENT COMPOSITION COMPRISING FATTY ACID PROCESSING ENZYMES
  申请人：The Procter & Gamble Company

  公开号：EP3483243A1

  公开（公告）日：2019-05-15

  A detergent composition, preferably a manual dishwashing detergent composition, comprising: a) one or more hydroperoxy fatty acid producing enzymes; b) one or more hydroperoxy fatty acid converting enzymes; and c) a surfactant system. Method of washing comprising the detergent composition are also provided.

  一种洗涤剂组合物，最好是手动洗碗机洗涤剂组合物，包括：a) 一种或多种氢过氧化脂肪酸生成酶；b) 一种或多种氢过氧化脂肪酸转化酶；和 c) 表面活性剂系统。还提供了包含该洗涤剂组合物的洗涤方法。
• DETERGENT COMPOSITION COMPRISING MODIFIED PROTEINS
  申请人：The Procter & Gamble Company

  公开号：EP3483240A1

  公开（公告）日：2019-05-15

  The present invention is directed to a detergent composition comprising a modified protein selected from the group consisting of modified ovalbumin, modified ovomucin, modified ovoglobulin, and mixtures thereof, and a surfactant system. Methods of making and using such compositions are also provided.

  本发明涉及一种洗涤剂组合物，该组合物包含一种从改性卵清蛋白、改性卵粘蛋白、改性卵球蛋白及其混合物组成的组中选出的改性蛋白质和一种表面活性剂系统。还提供了制造和使用这种组合物的方法。