Morpholin-N-carbonsaeure-<2-chlor-ethylester> | 89774-36-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: Morpholin-N-carbonsaeure-<2-chlor-ethylester>
• 英文别名: morpholine-4-carboxylic acid 2-chloro-ethyl ester；Morpholin-4-carbonsaeure-(2-chlor-aethylester)；2-Chloroethyl morpholine-4-carboxylate；2-chloroethyl morpholine-4-carboxylate
• CAS: 89774-36-7
• 化学式: C₇H₁₂ClNO₃
• 分子量: 193.63
• InChiKey: NSPWXRAOVCMWHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Morpholin-N-carbonsaeure-<2-chlor-ethylester> 在 potassium tert-butylate 作用下， 生成 乙烯基吗啉-4-羧酸酯
  参考文献：
  名称：

  Preparation and Polymerization of S-, O-, and N-Vinyl Derivatives of Carbonic Acid.¹ Unsaturated Carbonic Acid Derivatives. II

  摘要：

  DOI：

  10.1021/jo01059a047
• 作为产物：
  描述：

  morpholine-4-carboxylic acid-(2-hydroxy-ethyl ester) 在 氯化亚砜 作用下， 生成 Morpholin-N-carbonsaeure-<2-chlor-ethylester>
  参考文献：
  名称：

  Viard; Piganiol, 1950, p. 233,237

  摘要：

  DOI：

文献信息

• Malatesta; Migliaccio, Farmaco, Edizione Scientifica, 1956, vol. 11, p. 113,115
  作者：Malatesta、Migliaccio

  DOI：——

  日期：——
• Synthesis and Evaluation of Fenofibric Acid Ester Derivatives: Studies of Different Formulation with Their Bioavailability and Absorption Conditions
  作者：Zhixiang Lv、Zhou Wang、Fuyan Xiao、Guofan Jin

  DOI：10.21577/0103-5053.20190170

  日期：——

  A series of fenofibric acid ester pro-drugs (JF-1-7) were synthesized. The pharmacokinetic properties of these pro-drugs were examined after oral administration to rats at a dose of 20 mg kg(-1) to evaluate the relative bioavailability in rats. The bioavailability of the ester compounds, JF-1, 2, 3, 4, 5, 6, and 7, was significantly higher than that of fenofibrate. In particular, JF-2 proved to be most promising. The oral administration (20 mg kg(-1)) of JF-2 showed a relative bioavailability of approximately 272.8% compared to fenofibrate.
• Delaby et al., Bulletin de la Societe Chimique de France, 1951, p. 392,395
  作者：Delaby et al.

  DOI：——

  日期：——