6,7-O,O-demethylene-6,7-O,O-dimethylpodophyllotoxin | 18651-67-7

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 木脂素内酯
• 英文名称: 6,7-O,O-demethylene-6,7-O,O-dimethylpodophyllotoxin
• 英文别名: DMA-podophyllotoxin；(3aR)-4c-hydroxy-6,7-dimethoxy-9c-(3,4,5-trimethoxy-phenyl)-(3ar,9at)-3a,4,9,9a-tetrahydro-3H-naphtho[2,3-c]furan-1-one；(3aR)-4c-Hydroxy-6,7-dimethoxy-9c-(3,4,5-trimethoxy-phenyl)-(3ar,9at)-3a,4,9,9a-tetrahydro-3H-naphtho[2,3-c]furan-1-on；6,7-O-Demethylen-podophyllotoxin-dimethylaether；Sikkimotoxin；(3aR,4R,9R,9aR)-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-1-one
• CAS: 18651-67-7
• 化学式: C₂₃H₂₆O₈
• 分子量: 430.455
• InChiKey: JQNGRAVMNACCCG-MGNXDGSBSA-N

物化性质

• 熔点：
  120°
• 比旋光度：
  D25 -91.8°
• 沸点：
  606.7±55.0 °C(Predicted)
• 密度：
  1.268±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  92.7
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6,7-O,O-demethylene-6,7-O,O-dimethylpodophyllotoxin 在 4-二甲氨基吡啶 、 三氟化硼乙醚 、 sodium iodide 、 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 生成 [(3aR,4S,9R,9aR)-6,7-dimethoxy-1-oxo-9-(3,4,5-trimethoxyphenyl)-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-4-yl] butanoate
  参考文献：
  名称：

  Synthesis and Quantitative Structure–Activity Relationship (QSAR) Study of Novel 4-Acyloxypodophyllotoxin Derivatives Modified in the A and C Rings as Insecticidal Agents

  摘要：

  In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, we have synthesized three series of novel 4-acyloxy compounds derived from podophyllotoxin modified in the A and C rings, which is isolated as the main secondary metabolite from the roots and rhizomes of Podophyllum hexandrum. Their insecticidal activity was preliminarily evaluated against the pre-third-instar larvae of Mythimna separata in vivo. Compound 9g displayed the best promising insecticidal activity. It revealed that cleavage of the 6,7-methylenedioxy group of podophyllotoxin will lead to a less active compound and that the C-4 position of podophyllotoxin was the important modification location. A quantitative structure activity relationship (QSAR) model was developed by genetic algorithm combined with multiple linear regression (GA-MLR). For this model, the squared correlation coefficient (R-2) is 0.914, the leave-one-out cross-validation correlation coefficient (Q(LOO)(2)) is 0.881, and the root-mean-square error (RMSE) is 0.024. Five descriptors, BEHm2, Mor14v, Wap, G1v, and RDF020e, are likely to influence the biological activity of these compounds. Among them, two important ones are BEHm2 and Mor14v. This study will pave the way for further design, structural modification, and development of podophyllotoxin derivatives as insecticidal agents.

  DOI：

  10.1021/jf305011n
• 作为产物：
  描述：

  鬼臼毒素 在 三氯化硼 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 2.25h， 生成 6,7-O,O-demethylene-6,7-O,O-dimethylpodophyllotoxin
  参考文献：
  名称：

  Synthesis and Quantitative Structure–Activity Relationship (QSAR) Study of Novel 4-Acyloxypodophyllotoxin Derivatives Modified in the A and C Rings as Insecticidal Agents

  摘要：

  In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, we have synthesized three series of novel 4-acyloxy compounds derived from podophyllotoxin modified in the A and C rings, which is isolated as the main secondary metabolite from the roots and rhizomes of Podophyllum hexandrum. Their insecticidal activity was preliminarily evaluated against the pre-third-instar larvae of Mythimna separata in vivo. Compound 9g displayed the best promising insecticidal activity. It revealed that cleavage of the 6,7-methylenedioxy group of podophyllotoxin will lead to a less active compound and that the C-4 position of podophyllotoxin was the important modification location. A quantitative structure activity relationship (QSAR) model was developed by genetic algorithm combined with multiple linear regression (GA-MLR). For this model, the squared correlation coefficient (R-2) is 0.914, the leave-one-out cross-validation correlation coefficient (Q(LOO)(2)) is 0.881, and the root-mean-square error (RMSE) is 0.024. Five descriptors, BEHm2, Mor14v, Wap, G1v, and RDF020e, are likely to influence the biological activity of these compounds. Among them, two important ones are BEHm2 and Mor14v. This study will pave the way for further design, structural modification, and development of podophyllotoxin derivatives as insecticidal agents.

  DOI：

  10.1021/jf305011n

文献信息

• Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives☆
  作者：Xiao-Kang Zhu、Jian Guan、Zhiyan Xiao、L Mark Cosentino、Kuo-Hsiung Lee

  DOI：10.1016/j.bmc.2004.04.048

  日期：2004.8.1

  A series of novel podophyllotoxin derivatives containing structural modifications at C-4 (7-14), C-4' (16-17), and the methylenedioxy A-ring (23-28) was synthesized and tested for inhibition of HIV replication. Four of these compounds (25-28) were previously reported to show EC50 values of <0.001 mug/mL and therapeutic index (TI) values >120. Three of the newly tested compounds (8.. 12, and 20) showed good activity with EC50 values of 0.012, <0.001, and 0.389 mug/ml and TI values of 19.1, >16, and 19.4, respectively. A comparison of the anti-HIV activity of these derivatives suggested that an opened A-ring with 6,7-dimethoxy substitution and a 4'-demethylated E ring enhanced anti-HIV activity. (C) 2004 Elsevier Ltd. All rights reserved.
• Chatterjee; Chakravarti, Journal of the American Pharmaceutical Association (1912), 1952, vol. 41, p. 415,418
  作者：Chatterjee、Chakravarti

  DOI：——

  日期：——
• TAKANO, SEIICHI;SATO, NOBUAKI;OTAKI, SHIZUO;OGASAWARA, KUNIO, HETEROCYCLES, 25,(1987) NPEC. ISSUE, 69-73
  作者：TAKANO, SEIICHI、SATO, NOBUAKI、OTAKI, SHIZUO、OGASAWARA, KUNIO

  DOI：——

  日期：——