2-(1H-indol-3-yl)-N-(3-morpholinopropyl)-2-oxoacetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(1H-indol-3-yl)-N-(3-morpholinopropyl)-2-oxoacetamide
• 英文别名: 2-(1H-indol-3-yl)-N-(3-morpholin-4-ylpropyl)-2-oxoacetamide
• 化学式: C₁₇H₂₁N₃O₃
• 分子量: 315.372
• InChiKey: STRWPIQSFJTHMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  74.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(3-氨丙基)吗啉 、 吲哚-3-乙醛酰氯 以 四氢呋喃 为溶剂， 以70%的产率得到2-(1H-indol-3-yl)-N-(3-morpholinopropyl)-2-oxoacetamide
  参考文献：
  名称：

  Synthesis of marine alkaloid: 8,9-Dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents

  摘要：

  A series of marine alkaloid 8,9-dihydrocoseinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99-100% inhibition against promastigotes and 97-98% inhibition against amastigotes at a concentration of 10 mu g/ml. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.035

文献信息

• Synthesis of marine alkaloid: 8,9-Dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents
  作者：Leena Gupta、Archna Talwar、Nishi、Shraddha Palne、Suman Gupta、Prem M.S. Chauhan

  DOI：10.1016/j.bmcl.2007.04.035

  日期：2007.7

  A series of marine alkaloid 8,9-dihydrocoseinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99-100% inhibition against promastigotes and 97-98% inhibition against amastigotes at a concentration of 10 mu g/ml. (C) 2007 Elsevier Ltd. All rights reserved.