5-吡哆酸 | 524-07-2

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-吡哆酸
• 英文名称: 5-hydroxy-4-hydroxymethyl-6-methyl-nicotinic acid
• 英文别名: 5-Hydroxy-4-hydroxymethyl-6-methyl-nicotinsaeure；5-Pyridoxic acid；5-hydroxy-4-(hydroxymethyl)-6-methylpyridine-3-carboxylic acid
• CAS: 524-07-2
• 化学式: C₈H₉NO₄
• 分子量: 183.164
• InChiKey: VJZTVPVXKYQRJZ-UHFFFAOYSA-N

物化性质

• 熔点：
  282-283 °C (decomp)(Solv: ethanol (64-17-5))
• 沸点：
  543.3±50.0 °C(Predicted)
• 密度：
  1.480±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  90.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-甲基-3-羟基-4,5-二羟甲基吡啶 在 pseudomonas-cultures 作用下， 生成 5-吡哆酸
  参考文献：
  名称：

  Rodwell et al., Journal of Biological Chemistry, 1958, vol. 233, p. 1548,1552

  摘要：

  DOI：

文献信息

• Catalyst compositions and catalytic processes
  申请人：PHILLIPS PETROLEUM COMPANY

  公开号：EP0603557A1

  公开（公告）日：1994-06-29

  Catalytic compositions and catalytic processes are provided. The catalytic compositions are produced by the process that comprises contacting an organonickel compound with a cyclicazacarbyl compound. Optionally, one or more catalytic promoters can be present in the catalytic compositions. Additionally, one or more olefins can be contacted with one or more of these catalytic compositions to form oligomerization products and/or polymerization products.

  提供了催化组合物和催化工艺。催化组合物是通过将有机镍化合物与环氮羰基化合物接触的工艺生产的。催化组合物中可任选存在一种或多种催化促进剂。此外，一种或多种烯烃可与一种或多种这些催化组合物接触，以形成低聚产物和/或聚合产物。
• NOVEL PEPTIDE, AND ANTITHROMBOTIC AGENT, ANTICOAGULANT FOR EXTRACORPOREAL CIRCULATION, CELL FUSION INHIBITOR, CANCER METASTASIS INHIBITOR, PROTECTIVE FOR PLATELET PREPARATION FOR TRANSFUSION AND PACK OF PLATELET PREPARATION FOR TRANSFUSION
  申请人：NIPPON STEEL CORPORATION

  公开号：EP0628571A1

  公开（公告）日：1994-12-14

  The invention provides a novel peptide derivative comprising RGD as the basic skeleton and having antithrombotic, anticoagulant and cell fusion inhibiting effects. The invention provides also an antithrombotic agent which is efficacious against thrombosis and thrombolus during or after thrombolytic therapy and which can prevent the recurrence of such diseases and myocardial infarction, and anticoagulant for extracorporeal circulation which can inhibit clotting as the principal cause of thrombus during extracorporeal circulation, a cell fusion inhibitor, a cancer metastasis inhibitor, and a protective for a platelet preparation for transfusion, each containing the above derivative as the active ingredient. The invention further provides a pack of a platelet preparation for transfusion containing the derivative.

  本发明提供了一种新型多肽衍生物，它以 RGD 为基本骨架，具有抗血栓、抗凝血和抑制细胞融合的作用。本发明还提供了一种抗血栓剂，它对溶栓治疗期间或之后的血栓形成和血栓溶解具有疗效，并能防止此类疾病和心肌梗塞的复发、体外循环用抗凝剂，可抑制作为体外循环过程中血栓形成主要原因的凝血；细胞融合抑制剂；癌症转移抑制剂；输血用血小板制剂保护剂，每一种都含有上述衍生物作为活性成分。本发明进一步提供了一种含有上述衍生物的输血用血小板制剂包装。
• Methods for conducting assays for enzyme activity on protein microarrays
  申请人：Zhou X. Fang

  公开号：US20050118665A1

  公开（公告）日：2005-06-02

  The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput analysis of enzymatic reactions. The invention relates to methods of using protein chips to assay the presence, amount, activity and/or function of enzymes present in a protein sample on a protein chip. In particular, the methods of the invention relate to conducting enzymatic assays using a microarray wherein a protein and a substance are immobilized on the surface of a solid support and wherein the protein and the substance are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the substance and the protein. The invention also relates to microarrays that have an enzyme and a substrate immobilized on their surface wherein the enzyme and the substrate are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the enzyme and the substrate.

  本发明涉及在微阵列上进行酶活性测定的方法，这种方法可用于蛋白质功能的大规模研究、筛选测定和酶反应的高通量分析。本发明涉及使用蛋白质芯片检测蛋白质芯片上蛋白质样品中酶的存在、数量、活性和/或功能的方法。特别是，本发明的方法涉及使用芯片进行酶测定，其中蛋白质和物质被固定在固体支持物表面，蛋白质和物质相互靠近，足以使物质和蛋白质之间发生酶反应。本发明还涉及在其表面固定有酶和底物的微阵列，其中酶和底物相互靠近，足以使酶和底物之间发生酶反应。
• US5332708A
  申请人：——

  公开号：US5332708A

  公开（公告）日：1994-07-26
• US5461126A
  申请人：——

  公开号：US5461126A

  公开（公告）日：1995-10-24