2-甲氨基苯酚 | 611-24-5

• 物质功能分类: 化学试剂 - 有机试剂 - 芳香醇
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-甲氨基苯酚
• 中文别名: N-甲基-2-氨基苯酚
• 英文名称: o-(N-methylamino)phenol
• 英文别名: 2-(methylamino)phenol；N-methyl 2-aminophenol
• CAS: 611-24-5
• 化学式: C₇H₉NO
• mdl: MFCD00462180
• 分子量: 123.155
• InChiKey: JHKKTXXMAQLGJB-UHFFFAOYSA-N

物化性质

• 熔点：
  85-88 °C
• 沸点：
  229.26°C (rough estimate)
• 密度：
  1.0877 (rough estimate)
• 稳定性/保质期：
  避免与不相容的材料、光线、热源、水、空气或潮湿空气接触。

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R22
• WGK Germany：
  3
• 海关编码：
  2922299090
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302
• 储存条件：
  密封储存，应存放在阴凉、干燥的库房中。

SDS

Name:	2-Methylaminophenol 97+% Material Safety Data Sheet
Synonym:	None known
CAS:	611-24-5

Section 1 - Chemical Product MSDS Name:2-Methylaminophenol 97+% Material Safety Data Sheet
Synonym:None known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
611-24-5	2-Methylaminophenol	97.0+	210-263-5

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 611-24-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: almost white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 85 - 88 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C7H9NO
Molecular Weight: 123.15

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 611-24-5 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Methylaminophenol - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 37/39 Wear suitable gloves and eye/face
protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 611-24-5: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 611-24-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 611-24-5 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-甲氨基苯酚 在 五氯化磷 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以85%的产率得到
  参考文献：
  名称：

  磷（v）的2-氨基酚盐配体：具有手性[P（OC 6 H 4 NR）3 ] -阴离子的锂盐†

  摘要：

  通过用各自的2-氨基苯酚处理PCl 5来合成磷烷P（OC 6 H 4 NR）2（OC 6 H 4 NHR）[R = Me（2a），Ph（2b），C 6 F 5（2c）]导数（1a–c，3.1当量）。在一个实例中，分离出一种中间物质P（OC 6 H 4 NR）2 Cl [R = Me（3a）]，并对其结构进行了表征。磷烷2a和2b中胺部分（–N R）的去质子化用强碱金属碱（如正一个强有力的供体溶剂的存在正丁基锂）（例如THF），得到的盐组成的六配位P（的V）-anions [P（OC 6 H ^ 4 NR）3 ] -（R ＝ Me，[ 4a ] -； Ph，[ 4b ] -）。使用前体2a，分离出Li（THF）3 fac- [ 4a ] -盐。[ 4a ] -的每个对映异构体的X射线晶体经测定，据我们所知，它是包含具有P（V）–N键的六配位P（V）N 3 O 3阴离子的盐的第一个结构表征的例子。

  DOI：

  10.1039/c8dt02522c
• 作为产物：
  描述：

  2-硝基苯甲醚 在 盐酸 、 甲醇 、 tin 、 sodium methylate 作用下， 生成 2-甲氨基苯酚
  参考文献：
  名称：

  Diepolder, Chemische Berichte, 1899, vol. 32, p. 3525

  摘要：

  DOI：

文献信息

• 4-Nitropyrocatechol ethers as possible photoaffinity labels
  作者：A. Castello、J. Cervello、J. Marquet、M. Moreno-Mañas、X. Sirera

  DOI：10.1016/s0040-4020(01)87564-5

  日期：1986.1

  The photochemical reactions of O- and N-(2-methoxy-4-nitro)phenoxyalkyl derivatives of estrone and of the antibiotic cycloheximide with methylamine afford clean substitutions of the methoxy group. From these experiments it is inferred that 2-methoxy-4-nitrophenyl ethers can be good photoaffinity labels.

  雌酮的O-和N-（2-甲氧基-4-硝基）苯氧基烷基衍生物以及抗生素环己酰亚胺与甲胺的光化学反应提供了甲氧基的干净取代。从这些实验推断出2-甲氧基-4-硝基苯基醚可以是良好的光亲和标记。
• Photochemisch induzierte Reaktionen von 3-Amino-2H-azirinen
  作者：Kurt Dietliker、Heinz Heimgartner

  DOI：10.1002/hlca.19830660126

  日期：1983.2.2

  Photochemically Induced Reactions of 3-Amino-2H-azirines

  3-氨基-2 H-叠氮基的光化学诱导反应
• Reaction Discovery by Using a Sandwich Immunoassay
  作者：Julia Quinton、Sergii Kolodych、Manon Chaumonet、Valentina Bevilacqua、Marie-Claire Nevers、Hervé Volland、Sandra Gabillet、Pierre Thuéry、Christophe Créminon、Frédéric Taran

  DOI：10.1002/anie.201201451

  日期：2012.6.18

  Mmm, a reaction sandwich…︁ Using an immunoassay‐based technique able to monitor any kind of cross‐coupling reaction, a systematic and rapid evaluation of a large panel of random reactions was carried out. This approach led to the discovery of two new copper‐promoted reactions: a desulfurization reaction of thioureas leading to isoureas and a cyclization reaction leading to thiazole derivatives from

  嗯，反应夹心……︁使用基于免疫分析的技术能够监测任何种类的交叉偶联反应，对大量随机反应进行了系统，快速的评估。这种方法导致发现了两个新的铜促进的反应：硫脲的脱硫反应导致异脲，环化反应导致炔烃和N-羟基硫脲的噻唑衍生物。
• Method for sorting of pluripotent cells
  申请人：KYOTO UNIVERSITY

  公开号：US09335323B2

  公开（公告）日：2016-05-10

  A method for sorting pluripotent cells using a compound which is eliminated from the pluripotent cells through the MDR1 transporter.

  一种使用通过MDR1转运体从多能细胞中消除的化合物对多能细胞进行分类的方法。
• 6-Membered heterocyclic compound and use thereof
  申请人：Shoda Motoshi

  公开号：US20070060590A1

  公开（公告）日：2007-03-15

  A compound represented by the general formula (I) or a salt thereof: [T represents oxygen atom and the like; V represents CH 2 and the like; R O1 to R O4 represent hydrogen atom and the like; A represents a linear alkylene group or linear alkenylene group having 2 to 8 carbon atoms and the like; D represents carboxyl group and the like; X represents ethylene group, trimethylene group and the like; E represents —CH(OH)— group and the like; and W represent —U 1 —(R W1 )(R W2 )—U 2 —U 3 group (U 1 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; R W1 and R W2 represent hydrogen atom and the like; U 2 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; and U 3 represent an alkyl group having 1 to 8 carbon atoms and the like), or a residue of a carbon ring or heterocyclic compound], which can be utilized as an active ingredient of medicaments effective for prophylactic and/or therapeutic treatment of skeletal diseases such as osteoporosis and fracture, glaucoma, ulcerative colitis and the like.

  由通用公式(I)表示的化合物或其盐： [T代表氧原子等；V代表CH2等；RO1至RO4代表氢原子等；A代表具有2至8个碳原子的线型亚烷基或线型亚烯基等；D代表羧基等；X代表亚乙基、亚丙基等；E代表—CH(OH)—基团等；W代表—U1—(RW1)(RW2)—U2—U3基团（U1代表单键、具有1至4个碳原子的亚烷基等；RW1和RW2代表氢原子等；U2代表单键、具有1至4个碳原子的亚烷基等；U3代表具有1至8个碳原子的烷基等），或碳环或杂环化合物的残基]，其可作为预防性和/或治疗性药物的有效成分，用于治疗骨骼疾病如骨质疏松症和骨折、青光眼、溃疡性结肠炎等。