1,2-bis(2-(bromomethyl)phenoxy)ethane | 166192-10-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2-bis(2-(bromomethyl)phenoxy)ethane
• 英文别名: 1,2-bis(2-bromomethylphenoxy)ethane；1,2-bis-(2-bromomethyl-phenoxy)-ethane；1,2-Bis-(2-brommethyl-phenoxy)-aethan；1-(Bromomethyl)-2-[2-[2-(bromomethyl)phenoxy]ethoxy]benzene
• CAS: 166192-10-5
• 化学式: C₁₆H₁₆Br₂O₂
• 分子量: 400.11
• InChiKey: LJOMDZVNSHXHGJ-UHFFFAOYSA-N

物化性质

• 熔点：
  127-128 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  461.0±40.0 °C(Predicted)
• 密度：
  1.554±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-bis(2-(bromomethyl)phenoxy)ethane 在 sodium tetrahydroborate 、 对甲苯磺酸 、 potassium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 5.0h， 生成 10,29-diazaheptacyclo[27,6,1,1^3,10,0^4,9,0^12,17,0^30,35]heptatriaconta-1(36),3(37),4,6,8,12,14,16,22,24,26,30,32,34-tetradecaene
  参考文献：
  名称：

  羟甲基吲哚的异丙基取代反应中的甲烷化挤出*

  摘要：

  的3-hydroxymethylindoles一系列经历涉及酸催化的反应本位与甲醛的挤出和吲哚基甲烷基团的形成-electrophilic取代。分子间和分子内过程均导致大环化合物10和14。

  DOI：

  10.1071/ch17257
• 作为产物：
  描述：

  邻甲酚 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 sodium hydroxide 作用下， 以 四氢呋喃 、 四氯化碳 为溶剂， 反应 49.5h， 生成 1,2-bis(2-(bromomethyl)phenoxy)ethane
  参考文献：
  名称：

  1,4-Diazobicyclo(2,2,2)octane-modified multi-ammonium derivatives as ratiometric fluorescent sensors for lipopolysaccharide

  摘要：

  A series of pyrene derivatives bearing multi-quaternary ammonium 1,4-diazobicyclo(2,2,2)octane groups were synthesised as ratiometric fluorescent sensors for lipopolysaccharide (LPS) in aqueous solution. Ratiometric changes in fluorescence spectra of the sensors were observed from the pyrene monomerexcimer conversion which is modulated by the supramolecular self-assembly between sensors and LPS. These sensors show high selectivity towards LPS with the detection limit down to tens of nanomolar levels. The interaction mechanism between the sensors and LPS was also discussed.

  DOI：

  10.1080/10610278.2012.732224

文献信息

• Two threefold interpenetrated two-dimensional frameworks based on a flexible imidazole-containing ligand and benzene-1,4-dicarboxylate
  作者：Ning-Ning Yuan、Qi-Kui Liu、Jian-Ping Ma、Ru-Qi Huang、Yu-Bin Dong

  DOI：10.1107/s0108270111009383

  日期：2011.4.15

  polyether‐bridged flexible ligand 1,2‐bis[2‐(1H‐1,3‐imidazol‐1‐ylmethyl)phenoxy]ethane (L) has been used to create two two‐dimensional coordination polymers under hydrothermal reaction of L with CdII or CoII, in the presence of benzene‐1,4‐dicarboxylic acid (H2bdc). In poly[[(μ2‐benzene‐1,4‐dicarboxylato)μ‐1,2‐bis[2‐(1H‐1,3‐imidazol‐1‐ylmethyl)phenoxy]ethane}cadmium(II)] dihydrate], [Cd(C8H4O4)(C22H22N4O2)]·2H2O}n

  开链聚醚桥联柔性配体1,2-双[2-（1 H - 1,3-咪唑-1-1-甲基）苯氧基]乙烷（L）已用于在水热条件下生成两个二维配位聚合物L在苯-1,4-二羧酸（H 2 bdc）存在下与Cd II或Co II反应。在聚[（μ 2 -苯-1,4- dicarboxylato）μ-1,2-双[2-（1- ħ -1,3-咪唑-1-基甲基）苯氧基]乙烷}镉（II）]二水合物]，[Cd（C 8 H 4 O 4）（C 22 H 22 N 4 O 2）]·2H 2O} n，（I）和钴（II）类似物[Co（C 8 H 4 O 4）（C 22 H 22 N 4 O 2）]·2H 2 O} n，（II），Cd II和Co II阳离子与两个不同bdc 2-二价阴离子的四个羧酸O原子以螯合方式配位，两个N原子来自两个不同的L配体配位。金属离子，bdc 2-二价阴离子和L配体分别位于晶体学的双重轴上。bdc 2
• Synthesis of new macrocyclic bispidinone ionophores
  作者：David St C. Black、Mark A. Horsham、Michael Rose

  DOI：10.1016/0040-4020(95)00161-z

  日期：1995.4

  A linear synthesis, a convergent synthesis and cyclic Mannich reactions were used to prepare the macrocyclic bispidinone ionophores (6-7), (14) and (12-13). The convergent synthesis required successful alkylation of the N-unsubstituted bispidinone (9).
• Kyi, Huaxue Xuebao/Acta Chimica Sinica, 1959, vol. 25, p. 100,102
  作者：Kyi

  DOI：——

  日期：——
• Chi, Huaxue Xuebao/Acta Chimica Sinica, 1959, vol. 25, p. 100,101,103
  作者：Chi

  DOI：——

  日期：——
• A simple quinoline-based fluorescent “turn on” probe with high selectivity for Ag+ in aqueous media
  作者：Chang-Juan Chen、Ai-Jiang Zhang、Jiang-Bo Hu、Yu-Hang Miao、Xiang Liu

  DOI：10.1016/j.ica.2015.06.014

  日期：2015.8

  A simple quinoline-based fluorescent probe L for Ag+ has been developed. Probe L shows fluorescence enhancement (turn on) response towards Ag+ with high selectivity in aqueous media (methanol-water, v/v = 3: 7, pH 7.2, 20 mM Tris-HCl) based on a combinational effect of the inhibition of intermolecular photoinduced proton transfer and chelation-enhanced fluorescence. And an obvious fluorescent color change could be observed by naked eyes under the light of 365 nm. The binding mode between L and Ag+ has been found to be 1: 1 based on the fluorescence/absorption titration, ESI-MS and further confirmed by X-ray crystallography. (C) 2015 Elsevier B.V. All rights reserved.