6-diethylamino-O¹,O²-isopropylidene-6-deoxy-α-D-glucofuranose | 537-46-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-diethylamino-O¹,O²-isopropylidene-6-deoxy-α-D-glucofuranose
• 英文别名: 6-Diaethylamino-O¹,O²-isopropyliden-6-desoxy-α-D-glucofuranose；Methamphetamine；(2S)-N-methyl-1-phenylpropan-2-amine
• CAS: 537-46-2
• 化学式: C₁₃H₂₅NO₅
• 分子量: 275.345
• InChiKey: VTZSXQQXYBQHLW-IYKVGLELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  71.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  布洛芬 、 6-diethylamino-O¹,O²-isopropylidene-6-deoxy-α-D-glucofuranose 以2%的产率得到
  参考文献：
  名称：

  Fogassy Elemer, Acs Maria, Szili Timea, Simandi Bela, Sawinsky Janos, Tetrahedron Lett, 35 (1994) N 2, S 257-260

  摘要：

  DOI：
• 作为产物：
  描述：

  二乙胺 、 5,6-anhydro-1,2-O-isopropylidene-α-D-glucofuranose 生成 6-diethylamino-O¹,O²-isopropylidene-6-deoxy-α-D-glucofuranose
  参考文献：
  名称：

  Ohle et al., Chemische Berichte, 1936, vol. 69, p. 1636,1637

  摘要：

  DOI：

文献信息

• Method and reagents for detecting amphetamine and/or D-methamphetamine
  申请人：Abbott Laboratories

  公开号：US05262333A1

  公开（公告）日：1993-11-16

  This disclosure relates to a method and reagents for determining amphetamine and d-methamphetamine in a biological fluid, such as urine. In particular, this disclosure relates to improvements in a fluorescence polarization immunoassay procedure for determining the presence of amphetamine and d-methamphetamine in a single assay and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described includes pretreatment of the biological sample to eliminate cross reactants such as .beta.-hydroxyphenethylamine by preincubating the sample solely with an aqueous periodate solution having a pH from about 4.0 to about 7.5 without adjustment to an alkaline pH, and contacting the sample with riboflavin binding protein to reduce interference from fluorescent components in the sample. The procedure also maintains the cross reactivity of the immunoassay for tyramine at about 0.4% and for 1-methamphetamine below about 5.1% and eliminates the necessity of using controlled substances as starting materials.

  本公开涉及一种用于确定生物液体（例如尿液）中安非他命和d-甲基苯丙胺的方法和试剂。特别是，本公开涉及改进荧光偏振免疫测定程序，以确定单个测定中安非他命和d-甲基苯丙胺的存在，并涉及用作这种程序中试剂的新型示踪剂化合物类别。所描述的程序包括处理生物样品以消除交叉反应物，例如β-羟基苯乙胺，通过仅将样品与具有pH约为4.0至约7.5的水期酸溶液预孵育而不调整为碱性pH，并将样品与核黄素结合蛋白接触以减少样品中荧光成分的干扰。该程序还保持酪胺酸的免疫测定的交叉反应率约为0.4％，对1-甲基苯丙胺的交叉反应率低于约5.1％，并消除使用受控物质作为起始材料的必要性。
• N-Methyl-5-(4-nitrophenyl)-N-(a-methylphenethyl)furfurylamine
  申请人：Morton-Norwich Products, Inc.

  公开号：US04097500A1

  公开（公告）日：1978-06-27

  N-Methyl-5-(4-nitrophenyl)-N-(a-methylphenethyl)furfurylamine hydrochloride is useful as an antidepressant agent.

  N-甲基-5-(4-硝基苯基)-N-(α-甲基苯乙基)呋喃丙胺盐酸盐可用作抗抑郁药。
• Method of inhibiting methaphetamine synthesis
  申请人：——

  公开号：US20040049079A1

  公开（公告）日：2004-03-11

  A method of inhibiting or preventing the use of anhydrous ammonia as a solvent in a dissolving metal reduction process comprises adding to anhydrous ammonia a chemical reagent which is capable of scavenging solvated electrons generated when alkali or alkaline earth metal is dissolved in the anhydrous ammonia, the chemical reagent being added to the anhydrous ammonia such that when alkali metal is dissolved in the anhydrous ammonia containing the chemical reagent and thereafter ephedrine, pseudoephedrine or combination thereof is introduced to the anhydrous ammonia to produce a reaction product, the methamphetamine yield in the reaction product is below 50%, preferably below 10%. and more preferably below 1%. Preferred chemical reagents include Fe(III)citrate, ferrocene, 2-chloro-6-(trichloromethyl)pyridine and 1,1,1,2-tetrafluoroethane.

  一种抑制或预防无水氨作为溶剂在溶解金属还原过程中使用的方法，包括向无水氨中添加一种化学试剂，该化学试剂能够清除碱金属或碱土金属在无水氨中溶解时产生的溶剂化电子，该化学试剂被添加到无水氨中，使得当碱金属在含有该化学试剂的无水氨中溶解后，随后向无水氨中引入麻黄碱、伪麻黄碱或两者的组合以产生反应产物时，反应产物中的甲基苯丙胺收率低于50％，优选低于10％，更优选低于1％。优选的化学试剂包括Fe（III）柠檬酸盐，二茂铁，2-氯-6-（三氯甲基）吡啶和1,1,1,2-四氟乙烷。
• Crystallization Method for Benzphetamine
  申请人：Kalota Dennis J.

  公开号：US20080262268A1

  公开（公告）日：2008-10-23

  There is disclosed a method for the crystallization of benzphetamine hydrochloride from an organic medium by the steps of removing water from the system to a very low level and then reducing the temperature of the organic medium to provide crystallization of the acid salt. In the event that crystallization does not occur upon lowering the temperature of the medium, it has been discovered that gentle heating of the organic medium results in crystallization of the acid salt. It has also been discovered that higher temperature crystallization has been provided by removal of methamphetamine from the composition. The crystalline benzphetamine hydrochloride can then be isolated by typical liquid/solid separation means such as filtration or centrifugation.

  本文揭示了一种从有机介质中结晶苯丙胺盐酸盐的方法，其步骤包括将系统中的水分降至极低水平，然后降低有机介质的温度以提供酸盐的结晶。如果在降低介质温度时不发生结晶，则发现轻微加热有机介质会导致酸盐的结晶。还发现，通过从组成物中去除甲基苯丙胺，可以提供更高温度的结晶。然后，可以通过典型的液体/固体分离手段（如过滤或离心）分离结晶的苯丙胺盐酸盐。
• Detection of Methamphetamine Group Drugs
  申请人：Jehanli Ahmed Mohammed Taki

  公开号：US20080286816A1

  公开（公告）日：2008-11-20

  The present invention provides immunoassays which are highly specific for detection in biological samples of methamphetamine and other drugs of abuse of the methamphetamine group such as ecstasy and other ecstasy class drugs. More particularly, competitive assays are provided comprising: (a) contacting said sample with (i) a pseudoephedrine/carrier conjugate in which pseudoephedrine is linked via its hydroxyl group to the carrier and (ii) an antibody which is capable of binding both one or more drugs of the methamphetamine group and said conjugate; and (b) determining whether the binding of said antibody to said conjugate is reduced by the presence of said sample, a reduction in binding being indicative that the sample contains a methamphetamine group drug.

  本发明提供了高度特异性的免疫测定，用于检测生物样品中的甲基苯丙胺和其他甲基苯丙胺类滥用药物，如摇头丸和其他摇头丸类药物。更具体地，提供了竞争性测定，包括：(a)将样品与(i)伪麻黄碱/载体共轭物和(ii)能够结合甲基苯丙胺类药物和该共轭物的抗体接触；(b)确定抗体对共轭物的结合是否因样品的存在而减少，结合减少表明样品中含有甲基苯丙胺类药物。