4,4′-bis(benzoimidazol-1-yl) biphenyl | 1092975-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4,4′-bis(benzoimidazol-1-yl) biphenyl
• 英文别名: 4,4′-bis(benzoimidazo-1-ly)biphenyl；4,4′-bbibp；4,4'-bis(benzoimidazol-1-yl)biphenyl；4,4′-bis(benzimidazol-1-yl)biphenyl；4,4'-Bis(benzimidazol-1-yl)biphenyl；1-[4-[4-(benzimidazol-1-yl)phenyl]phenyl]benzimidazole
• CAS: 1092975-33-1
• 化学式: C₂₆H₁₈N₄
• 分子量: 386.456
• InChiKey: MEPZZRWGHGOPGC-UHFFFAOYSA-N

物化性质

• 沸点：
  632.0±65.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  palladium (II) nitrate 、 4,4′-bis(benzoimidazol-1-yl) biphenyl 以 二甲基亚砜 为溶剂， 反应 12.0h， 以76%的产率得到
  参考文献：
  名称：

  Self-Assembled Pd^II₆ Molecular Spheroids and Their Proton Conduction Property

  摘要：

  A series of molecular spheroids (SP1-SP4) was synthesized using pseudolinear bisimidazole and bisbenzimidazole donors in combination with Pd(NO3)(2) acceptor via coordination-driven self-assembly. They were characterized by NMR and mass spectrometry, and the solid-state structures of SP1 and SP3 were confirmed by X-ray diffraction. Crystal packing revealed the presence of molecular channels with water molecules in the channels as proton source. All the systems showed proton conductivity across a wide range of temperature and relative humidity. Furthermore, the mode of proton conduction in these molecular spheroids was explored by performing a control experiment using 2,4-dinitrophenol molecule, which indicates that the proton conductivity in the present case increases with increasing surface area of these molecular spheroids.

  DOI：

  10.1021/acs.inorgchem.8b00668
• 作为产物：
  描述：

  咪唑 、 苯并咪唑 在 potassium carbonate 、 copper(II) sulfate 作用下， 反应 24.0h， 以8%的产率得到4,4′-bis(benzoimidazol-1-yl) biphenyl
  参考文献：
  名称：

  The anti-malarial activity of bivalent imidazolium salts

  摘要：

  A series of compounds containing bivalent imidazolium rings and one triazolium analog were synthesized and evaluated for their ability to inhibit the replication of Plasmodium falciparum cultures. The activity and selectivity of the compounds for P. falciparum cultures were found to depend on the presence of electron-deficient rings that were spaced an appropriate distance apart. The activity of the compounds was not critically dependent on the nature of the linker between the electron-deficient rings, an observation that suggests that the rings were responsible for the primary interaction with the molecular target of the compounds in the parasite. The bivalent imidazolium and triazolium compounds disrupted the process whereby merozoites gain entry into erythrocytes, however, they did not appear to prevent merozoites from forming. The compounds were also found to be active in a murine Plasmodium berghei infection, a result consistent with the compounds specifically interacting with a parasite component that is required for replication and is conserved between two Plasmodium species. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.06.002

文献信息

• TRIAZOLIUM AND IMIDAZOLIUM SALTS AND USES THEREOF
  申请人：Crandall Ian E.

  公开号：US20110257235A1

  公开（公告）日：2011-10-20

  The present disclosure relates to certain new and known triazolium and/or imidazolium salts and to their therapeutic use, for example in methods of treating or preventing an infection by a Plasmodium or Babesia parasite in a subject in need thereof. The triazolium and imidazolium salts are compounds of the Formula (I) or (II): wherein R 1 -R 4 , R 1′ -R 3′ , R 8 -R 11 , X, X′, X″, Y, Y′ and Y″ are as defined in the disclosure.

  本公开涉及某些新的和已知的三唑和/或咪唑盐及其治疗用途，例如在治疗或预防受需要的主体中由Plasmodium或Babesia寄生虫引起的感染的方法中。三唑和咪唑盐是以下化合物的化合物：其中R1-R4，R1′-R3′，R8-R11，X，X′，X″，Y，Y′和Y″如本公开所定义。
• Controlling the BET Surface Area of Porous Carbon by Using the Cd/C Ratio of a Cd-MOF Precursor and Enhancing the Capacitance by Activation with KOH
  作者：Zuo-Xi Li、Xue Zhang、Yi-Chen Liu、Kang-Yu Zou、Man-Li Yue

  DOI：10.1002/chem.201603072

  日期：2016.12.5

  vapor, for the first time we have utilized these Cd–MOFs as precursors to further prepare porous carbon materials (PCs) in a calcination–thermolysis procedure. These PCs show different porous features that correspond to the topological structures of Cd–MOFs. Significantly, it was found that the specific surface area and capacitance of PCs are tuned by the Cd/C ratio of the MOF. Furthermore, the as‐synthesized

  在这里，四个新的镉金属有机框架（Cd–MOFs），[Cd（bib）（bdc）] ∞（1），[Cd（bbib）（bdc）（H 2 O）] ∞（2），[Cd （BIBP）（BDC）] ∞（3），和[CD 2（bbibp）2（BDC）2（H 2 O）] ∞（4），已经从镉的反应构建（NO 3）2 ⋅ 4 H 2 O与1,4-苯二甲酸（H 2bdc）和结构相关的双（咪唑）配体（1,4-双（咪唑-1-基）苯（bib），1,4-双（苯并咪唑-1-基）苯（bbib），4,4'溶剂热条件下的-双（咪唑-1-基）联苯（bibp）和4,4'-双（苯并咪唑-1-基）联苯（bbibp））。Cd–MOF 1显示了具有平行互穿的2D（4,4）晶格，而2显示了有趣的3D互穿的dia网络，3显示了不寻常的3D互穿的dmp网络，4显示了3D自分类的柱状层框架，其中[4施莱夫利符号3 ⋅ 6 3 ] 2 ⋅ [4 6 ⋅ 616
• Anions behaviors for the dimensionalities of coordination polymers based on poly(imidazole) ligands
  作者：Qinhe Pan、Hong Ma、Zuo-Xi Li、Tong-Liang Hu

  DOI：10.1016/j.molstruc.2011.12.025

  日期：2012.3

  one-dimensional (1D) chain structure. However, complexes 2 and 3 both present layered structures contain a similar -L(ligand)–M(metal)-L–M- chain motifs that found in complex 1. In complex 2, each Zn(II) ion is coordinated by four different L2 to form a undulated sheet. Complex 3 also present a undulated sheet structure, however, they were connected by the SO 4 2 - group and the L2 ligands, different from

  摘要 为了探讨配位聚合物维数的影响，在具有不同行为的不同阴离子的存在下，通过 M2+（M = Zn 或 Co）与两种结构相关的棒状聚（咪唑)配体、1,4-双(苯并咪唑-1-基)-苯基(L1)和1,4-双(咪唑-1-基)-苯基(L2)。这三种具有不同结构的新型配位聚合物，[Zn(L1)(NO3)2]n (1), [Zn(L2)2]·2BF4·2HCCl3·2H2O}n (2) 和 [Co(L2)( SO4)]n (3) 已通过单晶 X 射线衍射分析确定，并通过元素分析和红外分析进行表征。配合物 1 由八面体 Zn 中心和配体 L1 交替连接以表现出一维 (1D) 链结构。然而，配合物 2 和 3 均呈现层状结构，包含在配合物 1 中发现的类似 -L(配体)-M(金属)-L-M- 链基序。在配合物 2 中，每个 Zn(II) 离子由四个不同的 L2 配位形成一个起伏的薄片。配合物3也呈现起伏的片状结构，但它们由SO
• Three new coordination polymers based on an N-heterocyclic carboxylic acid: Structural diversity, luminescent properties and gas adsorption
  作者：Jinfang Liang、Jinxia Liang、Lijun Zhai、Haonan Wu、Xiaoyan Niu、Jie Zhang、Tuoping Hu

  DOI：10.1016/j.jssc.2019.120916

  日期：2019.12

  high sensitivity and selective detection towards Fe3+ ions with the low detection limit of 7.15 × 10−4 M−1 and 2.56 × 10−4 M−1, respectively. Gas adsorption behaviors show the adsorption amounts of 3a for CO2 advantage over those of CH4 and N2. The selectivities of 3a for CO2/CH4 were estimated by the ideal adsorbed solution theory (IAST), which are 4.78 for land fill gas (CO2:CH4 = 0.50:0.50) and

  基于混合配体策略，三种新的配位聚合物（CP）分别为[Zn 2（TZMB）2（bim）]·2DMA·EtOH} n （1），[Zn 2（TZMB）2（4， 4'-bibp）·2DMA·EtOH]} n （2）和[Cd（TZMB）（bbibp）] DMA·EtOH} n （3）（bim =苯并咪唑，4,4'-bipb = 4，通过4,4的反应已成功合成了4'-双（吡啶-4-基）联苯，bbibp = 4,4'-双（苯并咪唑基-1-基）联苯，DMA = N，N-二甲基乙酰胺）在溶剂热法下，'-（1H-1,2,4-三唑-1-基）亚甲基双（苯甲酸）（H 2 TZMB）和Zn（II）/ Cd（II）。结构分析表明1显示具有6 3 } 6 5 .8}拓扑的2节点（3,4）-c 3D框架，2显示具有与1相同拓扑的稀有1D + 1D→3D框架，而3是3D超分子通过2 5 .8}拓扑在相邻2D层之间
• Adjusting the Porosity and Interpenetration of Cadmium(II) Coordination Polymers by Ligand Modification: Syntheses, Structures, and Adsorption Properties
  作者：Zuo-Xi Li、Tong-Liang Hu、Hong Ma、Yong-Fei Zeng、Cui-Jin Li、Ming-Liang Tong、Xian-He Bu

  DOI：10.1021/cg900980y

  日期：2010.3.3

  frameworks (MOFs) based on six-connected CdII nodes which are octahedrally coordinated by six nitrogen atoms of ligand molecules. Complex 2 represents a distorted α-Po framework with noninterpenetration, whereas 1 and 3 both exhibit a double interpenetrating α-Po network. These results suggest that the degree of interpenetration is tunable by ligand modifications, that is, varying the ligand spacer or

  一系列结构相关的刚性咪唑配体，1,4-双（咪唑-1-基）苯（L 1），1,4-双（苯并咪唑-1-基）苯（L 2）和4,4' -双（苯并咪唑-1-基）联苯（L 3）已被用于构建配位聚合物。CDX的反应2（X = BF 4 -或C10 4 - ）与这些配体得到三个新的三维网络，[CD（大号1）3 ]（BF 4）2（氯仿3）2 } ∞（1），[Cd（L2） 3 ]（ClO 4） 2（CHCl 3） 4（CH 3 OH） 2 } ∞（ 2）和[Cd（ L 3） 3 ]（ClO 4） 2 } ∞（ 3）。化合物1 - 3是根据6个连接的CD的所有α-宝金属-有机骨架（MOF） II被八面体通过配体分子的六个氮配位的节点。配合物2表示扭曲且不互穿的α-Po骨架，而图1和图3均显示出双重互穿的α-Po网络。这些结果表明，互穿度可通过配体修饰来调节，即，改变配体间隔基或端基。这三种络合物在其网络中表