methyl 11α-azido-3α,7α-diacetoxy-12-oxo-5β-cholan-24-oate | 851086-19-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: methyl 11α-azido-3α,7α-diacetoxy-12-oxo-5β-cholan-24-oate
• 英文别名: methyl 11α-azido-3α,7α-diaceoxy-12-oxo-5β-cholan-24-oate；methyl (4R)-4-[(3R,5S,7R,8S,9S,10S,11S,13R,14S,17R)-3,7-diacetyloxy-11-azido-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoate
• CAS: 851086-19-6
• 化学式: C₂₉H₄₃N₃O₇
• 分子量: 545.676
• InChiKey: HDYPAVVYAXYFBB-IBJFPTGSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  110
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  methyl 11α-azido-3α,7α-diacetoxy-12-oxo-5β-cholan-24-oate 在 十六烷基三甲基溴化铵 、 cobalt(II) chloride 、 sodium tetrahydroborate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 0.75h， 以86%的产率得到methyl (4R)-4-[(3R,5S,7R,8S,9S,10S,11S,12R,13R,14S,17R)-3,7-diacetyloxy-11-amino-12-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
  参考文献：
  名称：

  Amino Functionalized Novel Cholic Acid Derivatives Induce HIV-1 Replication and Syncytia Formation in T Cells

  摘要：

  Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.

  DOI：

  10.1021/jm051114u
• 作为产物：
  描述：

  胆酸甲酯 在 4-二甲氨基吡啶 、 Jones reagent 、 sodium azide 、 溴 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 丙酮 、 苯 为溶剂， 反应 160.08h， 生成 methyl 11α-azido-3α,7α-diacetoxy-12-oxo-5β-cholan-24-oate
  参考文献：
  名称：

  [EN] 11 -SUBSTITUTED BILE ACID DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE OF THESE COMPOUNDS AS MEDICAMENTS
  [FR] DÉRIVÉS D'ACIDES BILIAIRES 11-SUBSTITUÉS, LEUR PROCÉDÉ DE PRÉPARATION ET UTILISATION DE CES COMPOSÉS À TITRE DE MÉDICAMENTS

  摘要：

  本发明公开了一种在C-11处具有取代氮功能的新型胆酸衍生物，以及其合成方法。这些C-11取代的胆酸衍生物表现出抗癌和抗结核活性。

  公开号：

  WO2015087340A1

文献信息

• Synthesis of Bile Acid Dimers Linked with 1,2,3-Triazole Ring at C-3, C-11, and C-24 Positions
  作者：Vandana S. Pore、Nilkanth G. Aher

  DOI：10.1055/s-2005-872223

  日期：——

  1,3-Dipolar cycloaddition of propargyl ester of a bile acid to an azide group attached at different positions of another bile acid gave three new 1,2,3-triazole-containing dimeric analogues in excellent yields.

  将一种胆汁酸的丙炔基酯与另一种胆汁酸不同位置上的叠氮基进行 1,3-二极环加成，得到了三种新的含 1,2,3-三唑的二聚类似物，产量极高。
• 11-substituted bile acid derivatives, process for the preparation thereof and use of these compounds as medicaments
  申请人：Council of Scientific and Industrial Research

  公开号：US10000527B2

  公开（公告）日：2018-06-19

  The present invention discloses a novel bile acid derivatives having substituted nitrogen functionality at C-11 and process for synthesis thereof. These C-11 substituted bile acid derivatives shows anticancer and antimycobacterial activity.

  本发明公开了一种 C-11 位具有取代氮官能团的新型胆汁酸衍生物及其合成工艺。这些 C-11 取代的胆汁酸衍生物具有抗癌和抗霉菌活性。
• Design and synthesis of 11α-substituted bile acid derivatives as potential anti-tuberculosis agents
  作者：Vandana S. Pore、Jaisingh M. Divse、Chaitanya R. Charolkar、Laxman U. Nawale、Vijay M. Khedkar、Dhiman Sarkar

  DOI：10.1016/j.bmcl.2015.08.006

  日期：2015.10

  We have synthesized a series of novel 11 alpha-triazoyl bile acid derivatives. In addition, we also have synthesized N-alkyl and N-acyl derivatives of C-11 amino bile acid esters. All the compounds were evaluated for the inhibitory activity against Mycobacterium tuberculosis H37Ra (MTB) at 30 mu g/mL level. Four lead compounds (2b, 3, 7 and 8) were further confirmed from their dose dependent effect against MTB. These compounds were found to be active against Dormant and active stage MTB under both in vitro as well as within THP1 host macrophages. The most promising compound 2b showed strong antitubercular activities against MTB under in vitro and ex vivo (IC90 value of similar to 3 mu g/mL) conditions and almost insignificant cytotoxicity up to 100 mu g/mL against THP-1, A549 and PANC-1 human cancer cell lines. Inactivity of all these compounds against Gram positive and Gram negative bacteria indicates their specificity. Molecular docking studies of these compounds into the active site of DprE1 enzyme revealed a similar binding mode to native ligands in the crystal structure thereby helping to establish a structural basis of inhibition of MTB. The synthesized compounds were analyzed for ADME properties and showed potential to develop good oral drug candidates. Our results clearly indicate the identification of some novel, selective and specific inhibitors against MTB that can be explored further for potential antitubercular drug. (C) 2015 Elsevier Ltd. All rights reserved.
• An efficient method for the synthesis of methyl 11α-amino-3α,7α-diacetoxy-12-oxo-5β-cholan-24-oate
  作者：Deepak B. Salunke、Braja G. Hazra、Rajesh G. Gonnade、Mohan M. Bhadbhade、Vandana S. Pore

  DOI：10.1016/j.tet.2005.01.073

  日期：2005.4

  The synthesis of methyl 11 alpha-azido-3 alpha,7 alpha-diacetoxy-12-oxo-5 beta-cholan-24-oate, methyl 11 beta-azido-3 alpha,7 alpha-diacetoxy-12-oxo-5 beta-cholan-24-oate and methyl 11 alpha-amino-3 alpha,7 alpha-diacetoxy-12-oxo-5 beta-cholan-24-oate have been achieved. Mechanistic aspects for the decomposition of steroidal azidoketones to its enamines are discussed. (c) 2005 Elsevier Ltd. All rights reserved.
• 11-SUBSTITUTED BILE ACID DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE OF THESE COMPOUNDS AS MEDICAMENTS
  申请人：Council of Scientific and Industrial Research

  公开号：US20160311848A1

  公开（公告）日：2016-10-27

  The present invention discloses a novel bile acid derivatives having substituted nitrogen functionality at C-11 and process for synthesis thereof. These C-11 substituted bile acid derivatives shows anticancer and antimycobacterial activity.