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{4-[1-(3-benzyloxy-6-methyl-pyridin-2-ylmethyl)-4-methyl-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-acetic acid ethyl ester | 856706-29-1

中文名称
——
中文别名
——
英文名称
{4-[1-(3-benzyloxy-6-methyl-pyridin-2-ylmethyl)-4-methyl-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-acetic acid ethyl ester
英文别名
Ethyl 2-[4-[[4-methyl-1-[(6-methyl-3-phenylmethoxypyridin-2-yl)methyl]benzimidazol-2-yl]amino]piperidin-1-yl]acetate
{4-[1-(3-benzyloxy-6-methyl-pyridin-2-ylmethyl)-4-methyl-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-acetic acid ethyl ester化学式
CAS
856706-29-1
化学式
C31H37N5O3
mdl
——
分子量
527.666
InChiKey
BSELCGDXYCEPRW-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    5.4
  • 重原子数:
    39
  • 可旋转键数:
    11
  • 环数:
    5.0
  • sp3杂化的碳原子比例:
    0.39
  • 拓扑面积:
    81.5
  • 氢给体数:
    1
  • 氢受体数:
    7

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    {4-[1-(3-benzyloxy-6-methyl-pyridin-2-ylmethyl)-4-methyl-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-acetic acid ethyl ester 在 lithium aluminium tetrahydride 、 作用下, 以 四氢呋喃 为溶剂, 反应 2.0h, 以71.6%的产率得到2-{4-[1-(3-benzyloxy-6-methyl-pyridin-2-ylmethyl)-4-methyl-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethanol
    参考文献:
    名称:
    [EN] PIPERIDINE-AMINO-BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION
    [FR] DERIVES PIPERIDINE-AMINO-BENZIMIDAZOLE EN TANT QU'INHIBITEURS DE LA REPLICATION DU VIRUS RESPIRATOIRE SYNCYTIAL
    摘要:
    本发明涉及具有抑制呼吸道合胞病毒复制活性的哌啶-氨基-苯并咪唑类化合物,其具有通式(I),及其前药、N-氧化物、加成盐、季铵盐、金属络合物和立体化学异构体,其中Q为C1-6烷基,可选择性地被三氟甲基、C3-7环烷基、Ar2、羟基、C1-4烷氧基、C1-4烷基硫基、Ar2-氧-、Ar2-硫-、Ar2(CH2)n氧、Ar2(CH2)n硫、羟基羰基、氨基羰基、C1-4烷基羰基、Ar2羰基、C1-4烷氧基羰基、Ar2(CH2)n羰基、氨基羰基氧、C1-4烷基羰基氧、Ar2羰基氧、Ar2(CH2)n羰基氧、C1-4烷氧基羰基(CH2)n氧、单或二(C1-4烷基)氨基羰基、单或二(C1-4烷基)氨基羰基氧、氨基磺酰基、单或二(C1-4烷基)氨基磺酰基或选自吡咯烷基、吡咯基、二氢吡咯基、咪唑基、三唑基、哌啶基、高哌啶基、哌嗪基、吗啉基、硫代吗啉基、1-氧代-硫代吗啉基、1,1-二氧代-硫代吗啉基、吡啶基和四氢吡啶基的杂环,其中所述的每个杂环可选择性地被羰基或C1-6烷基取代;G为直接键或可选择性取代的C1-10亚烷基;R1为Ar1或单环或双环杂环;R2a和R3a中的一个是C1-6烷基,另一个是氢;如果R2a不同于氢,则R2b为氢或C1-6烷基,R3b为氢;如果R3a不同于氢,则R3b为氢或C1-6烷基,R2b为氢;t为1、2或3;Ar1为苯基或取代苯基;Ar2为苯基或取代苯基。本发明还涉及它们的制备方法和包含它们的组合物,以及它们作为药物的用途。
    公开号:
    WO2005058873A1
  • 作为产物:
    描述:
    [1-(3-benzyloxy-6-methyl-pyridin-2-ylmethyl)-4-methyl-1H-benzoimidazol-2-yl]-piperidin-4-yl-amine氯乙酸乙酯potassium carbonate 作用下, 以 乙腈 为溶剂, 反应 12.0h, 以90%的产率得到{4-[1-(3-benzyloxy-6-methyl-pyridin-2-ylmethyl)-4-methyl-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-acetic acid ethyl ester
    参考文献:
    名称:
    [EN] PIPERIDINE-AMINO-BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION
    [FR] DERIVES PIPERIDINE-AMINO-BENZIMIDAZOLE EN TANT QU'INHIBITEURS DE LA REPLICATION DU VIRUS RESPIRATOIRE SYNCYTIAL
    摘要:
    本发明涉及具有抑制呼吸道合胞病毒复制活性的哌啶-氨基-苯并咪唑类化合物,其具有通式(I),及其前药、N-氧化物、加成盐、季铵盐、金属络合物和立体化学异构体,其中Q为C1-6烷基,可选择性地被三氟甲基、C3-7环烷基、Ar2、羟基、C1-4烷氧基、C1-4烷基硫基、Ar2-氧-、Ar2-硫-、Ar2(CH2)n氧、Ar2(CH2)n硫、羟基羰基、氨基羰基、C1-4烷基羰基、Ar2羰基、C1-4烷氧基羰基、Ar2(CH2)n羰基、氨基羰基氧、C1-4烷基羰基氧、Ar2羰基氧、Ar2(CH2)n羰基氧、C1-4烷氧基羰基(CH2)n氧、单或二(C1-4烷基)氨基羰基、单或二(C1-4烷基)氨基羰基氧、氨基磺酰基、单或二(C1-4烷基)氨基磺酰基或选自吡咯烷基、吡咯基、二氢吡咯基、咪唑基、三唑基、哌啶基、高哌啶基、哌嗪基、吗啉基、硫代吗啉基、1-氧代-硫代吗啉基、1,1-二氧代-硫代吗啉基、吡啶基和四氢吡啶基的杂环,其中所述的每个杂环可选择性地被羰基或C1-6烷基取代;G为直接键或可选择性取代的C1-10亚烷基;R1为Ar1或单环或双环杂环;R2a和R3a中的一个是C1-6烷基,另一个是氢;如果R2a不同于氢,则R2b为氢或C1-6烷基,R3b为氢;如果R3a不同于氢,则R3b为氢或C1-6烷基,R2b为氢;t为1、2或3;Ar1为苯基或取代苯基;Ar2为苯基或取代苯基。本发明还涉及它们的制备方法和包含它们的组合物,以及它们作为药物的用途。
    公开号:
    WO2005058873A1
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文献信息

  • Piperdine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
    申请人:Bonfanti Jean-Francois
    公开号:US20070093659A1
    公开(公告)日:2007-04-26
    The present invention concerns piperidine-amino-benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms wherein Q is C 1-6 alkyl optionally substituted with trifluoromethyl, C 3-7 cycloalkyl, Ar 2 , hydroxy, C 1-4 alkoxy, C 1-4 alkylthio, Ar 2 -oxy-, Ar 2 -thio-, Ar 2 (CH 2 ) n oxy, Ar 2 (CH 2 ) n thio, hydroxycarbonyl, aminocarbonyl, C 1-4 alkylcarbonyl, Ar 2 carbonyl, C 1-4 alkoxycarbonyl, Ar 2 (CH 2 ) n carbonyl, aminocarbonyloxy, C 1-4 alkylcarbonyloxy, Ar 2 carbonyloxy, Ar 2 (CH 2 ) n carbonyloxy, C 1-4 alkoxy-carbonyl(CH 2 ) n oxy, mono- or di(C 1-4 alkyl)aminocarbonyl, mono- or di(C 1-4 alkyl)-aminocarbonyloxy, aminosulfonyl, mono- or di(C 1-4 alkyl)aminosulfonyl or a heterocycles selected from the group consisting of pyrrolidinyl, pyrrolyl, dihydropyrrolyl, imidazolyl, triazolyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, pyridyl and tetrahydropyridyl, wherein each of said heterocycle may optionally be substituted with oxo or C 1-6 alkyl; G is a direct bond or optionally substituted C 1-10 alkanediyl; R 1 is Ar 1 or a monocyclic or bicyclic heterocycle; one of R 2a and R 3a is C 1-6 alkyl and the other one of R 2a and R 3a is hydrogen; in case R 2a is different from hydrogen then R 2b is hydrogen or C 1-6 alkyl, and R 3b is hydrogen; in case R 3a is different from hydrogen then R 3b is hydrogen or C 1-6 alkyl, and R 2b is hydrogen; t is 1, 2 or 3; Ar 1 is phenyl or substituted phenyl; and Ar 2 is phenyl or substituted phenyl. It further concerns their preparation and compositions comprising them, as well as their use as a medicine.
    本发明涉及具有对呼吸合胞病毒复制具有抑制活性的哌啶基氨基苯并咪唑,其具有以下式子,它们的前药,N-氧化物,加成盐,季铵盐,金属配合物和立体化学异构体形式,其中Q是C1-6烷基,可选地被三氟甲基取代,C3-7环烷基,Ar2,羟基,C1-4烷氧基,C1-4烷基硫基,Ar2-氧基,Ar2-硫基,Ar2(CH2)noxy,Ar2(CH2)nthio,羟基羧酸,氨基羧酸,C1-4烷基羧酸,Ar2羧酸,C1-4烷氧羧酸,Ar2(CH2)ncarbonyl,氨基羧酸氧酯,C1-4烷基羧酸氧酯,Ar2羧酸氧酯,Ar2(CH2)ncarbonyloxy,C1-4烷氧基羧酸(CH2)noxy,单一或二(C1-4烷基)氨基羧酸,单一或二(C1-4烷基)氨基羧酸氧酯,氨基磺酰基,单一或二(C1-4烷基)氨基磺酰基或从吡咯烷基,吡咯基,二氢吡咯基,咪唑基,三唑基,哌啶基,同源哌啶基,哌嗪基,吗啉基,噻吗啉基,1-氧代噻吗啉基,1,1-二氧代噻吗啉基,吡啶基和四氢吡啶基中选择的杂环,其中每个所述杂环可选地被氧代或C1-6烷基取代;G是直接键或可选地取代的C1-10烷二基;R1是Ar1或单环或双环杂环;R2a和R3a中的一个是C1-6烷基,另一个是氢;在R2a与氢不同的情况下,R2b是氢或C1-6烷基,R3b是氢;在R3a与氢不同的情况下,R3b是氢或C1-6烷基,R2b是氢;t为1、2或3;Ar1为苯基或取代苯基;Ar2为苯基或取代苯基。本发明还涉及它们的制备和包含它们的组合物,以及它们作为药物的用途。
  • PIPERIDINE-AMINO-BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION
    申请人:BONFANTI Jean-Francois
    公开号:US20080146613A1
    公开(公告)日:2008-06-19
    The present invention concerns piperidine-amino-benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms wherein Q is C 1-6 alkyl optionally substituted with trifluoromethyl, C 3-7 cycloalkyl, Ar 2 , hydroxy, C 1-4 alkoxy, C 1-4 alkylthio, Ar 2 -oxy-, Ar 2 -thio-, Ar 2 (CH 2 ) n oxy, Ar 2 (CH 2 ) n thio, hydroxycarbonyl, aminocarbonyl, C 1-4 alkyl-carbonyl, Ar 2 -carbonyl, C 1-4 alkoxycarbonyl, Ar 2 (CH 2 ) n carbonyl, aminocarbonyloxy, C 1-4 alkylcarbonyloxy, Ar 2 -carbonyloxy, Ar 2 (CH 2 ) n carbonyloxy, C 1-4 alkoxy-carbonyl(CH 2 ) n oxy, mono- or di(C 1-4 alkyl)aminocarbonyl, mono- or di(C 1-4 alkyl)-aminocarbonyloxy, aminosulfonyl, mono- or di(C 1-4 alkyl)aminosulfonyl or a heterocycles selected from the group consisting of pyrrolidinyl, pyrrolyl, dihydropyrrolyl, imidazolyl, triazolyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, pyridyl and tetrahydropyridyl, wherein each of said heterocycle may optionally be substituted with oxo or C 1-6 alkyl; G is a direct bond or optionally substituted C 1-10 alkanediyl; R 1 is Ar 1 or a monocyclic or bicyclic heterocycle; one of R 2a and R 3a is C 1-6 alkyl and the other one of R 2a and R 3a is hydrogen; in case R 2a is different from hydrogen then R 2b is hydrogen or C 1-6 alkyl, and R 3b is hydrogen; in case R 3a is different from hydrogen then R 3b is hydrogen or C 1-6 alkyl, and R 2b is hydrogen; t is 1, 2 or 3; Ar 1 is phenyl or substituted phenyl; and Ar 2 is phenyl or substituted phenyl. It further concerns their preparation and compositions comprising them, as well as their use as a medicine.
    本发明涉及对呼吸道合胞病毒复制具有抑制活性的哌啶基氨基苯并咪唑,其具有以下式子: 其中Q是C1-6烷基,可选地取代三氟甲基,C3-7环烷基,Ar2,羟基,C1-4烷氧基,C1-4烷基硫基,Ar2-氧基,Ar2-硫基,Ar2(CH2)noxy,Ar2(CH2)nthio,羟基羧酸,氨基羧酸,C1-4烷基羧酸,Ar2-羧酸,C1-4烷氧基羧酸,Ar2(CH2)ncarbonyl,氨基羧酸氧酸酯,C1-4烷基羧酸氧酸酯,Ar2-羧酸氧酸酯,Ar2(CH2)ncarbonyloxy,C1-4烷氧基-羧酸(CH2)noxy,单烷基或双烷基氨基羧酸,单烷基或双烷基氨基羧酸氧酸酯,氨基磺酰基,单烷基或双烷基氨基磺酰基或从吡咯烷基,吡咯基,二氢吡咯基,咪唑基,三唑基,哌啶基,同型哌啶基,哌嗪基,吗啉基,硫代吗啉基,1-氧代硫代吗啉基,1,1-二氧代硫代吗啉基,吡啶基和四氢吡啶基中选择的杂环,其中每个所述杂环可以选择地用氧代或C1-6烷基取代;G是直接键或可选取代的C1-10烷基二基基;R1是Ar1或单环或双环杂环;R2a和R3a中的一个是C1-6烷基,另一个是氢;如果R2a不同于氢,则R2b是氢或C1-6烷基,而R3b是氢;如果R3a不同于氢,则R3b是氢或C1-6烷基,而R2b是氢;t为1、2或3;Ar1为苯基或取代苯基;Ar2为苯基或取代苯基。本发明还涉及它们的制备和包含它们的组合物,以及它们作为药物的用途。
  • Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate, Part 1:  Improving the Pharmacokinetic Profile Using the Structure−Property Relationship
    作者:Jean-François Bonfanti、Frédéric Doublet、Jérôme Fortin、Jean Lacrampe、Jérôme Guillemont、Philippe Muller、Laurence Queguiner、Eric Arnoult、Tom Gevers、Peggy Janssens、Heidi Szel、Rudy Willebrords、Philip Timmerman、Koen Wuyts、Frans Janssens、Cois Sommen、Piet Wigerinck、Koen Andries
    DOI:10.1021/jm070143x
    日期:2007.9.1
    We previously reported the discovery of substituted benzimidazole fusion inhibitors with nanomolar activity against respiratory syncytial virus (Andries, K.; et al. Antiviral Res. 2003, 60, 209-219). A lead compound of the series was selected for preclinical evaluation. This drug candidate, JNJ-2408068 (formerly R 17059 1, 1), showed long tissue retention times in several species (rat, dog, and monkey), creating cause for concern. We herein describe the optimization program to develop compounds with improved properties in terms of tissue retention. We have identified the aminoethyl-piperidine moiety as being responsible for the long tissue retention time of 1. We have investigated the replacement or the modification of this group, and we suggest that the pK(a) of this part of the molecules influences both the antiviral activity and the pharmacokinetic profile. We were able to identify new respiratory syncytial virus inhibitors with shorter half-lives in lung tissue.
  • US7355051B2
    申请人:——
    公开号:US7355051B2
    公开(公告)日:2008-04-08
  • [EN] PIPERIDINE-AMINO-BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION<br/>[FR] DERIVES PIPERIDINE-AMINO-BENZIMIDAZOLE EN TANT QU'INHIBITEURS DE LA REPLICATION DU VIRUS RESPIRATOIRE SYNCYTIAL
    申请人:TIBOTEC PHARM LTD
    公开号:WO2005058873A1
    公开(公告)日:2005-06-30
    The present invention concerns piperidine-amino-benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I) their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms wherein Q is C1-6alkyl optionally substituted with trifluorornethyl, C3-7cycloalkyl, Ar2, hydroxy, C1-4 alkoxy, C1-4alkylthio, Ar2-oxy-, Ar2-thio-, Ar2(CH2)noxy, Ar2(CH2)nthio, hydroxycarbonyl, aminocarbonyl, C1-4alkyl­carbonyl, Ar2carbonyl, C1-4alkoxycarbonyl, Ar2(CH2)ncarbonyl, aminocarbonyloxy, C1-4alkylcarbonyloxy, Ar2carbonyloxy, Ar2(CH2)ncarbonyloxy, C1-4alkoxy­ carbonyl(CH2)noxy, mono- or di(C1-4alkyl)aminocarbonyl, mono- or di(C1-4alkyl)-­aminocarbonyloxy, aminosulfonyl, mono-odi(C1-4alkyl)aminosulfonyl or a heterocycles selected from the group consisting of pyrrolidinyl, pyrrolyl, dihydropyrrolyl, imidazolyl, triazolyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, pyridyl and tetrahydropyridyl, wherein each of said heterocycle may optionally be substituted with oxo or C1-6alkyl; G is a direct bond or optionally substituted Cl-10 loalkanediyl; R1 is Ar1 or a monocyclic or bicyclic heterocycle; one of R2a and R3a is C1-6 salkyl and the other one of R2a and R3a is hydrogen; in case R2a is different from hydrogen then R2b is hydrogen or C1-6alkyl, and R3b is hydrogen; in case R3a is different from hydrogen then R3b is hydrogen or C1-6alkyl, and R2b is hydrogen; t is 1, 2 or 3; Ar1 is phenyl or substituted phenyl; and Ar2 is phenyl or substituted phenyl. It further concerns their preparation and compositions comprising them, as well as their use as a medicine.
    本发明涉及具有抑制呼吸道合胞病毒复制活性的哌啶-氨基-苯并咪唑类化合物,其具有通式(I),及其前药、N-氧化物、加成盐、季铵盐、金属络合物和立体化学异构体,其中Q为C1-6烷基,可选择性地被三氟甲基、C3-7环烷基、Ar2、羟基、C1-4烷氧基、C1-4烷基硫基、Ar2-氧-、Ar2-硫-、Ar2(CH2)n氧、Ar2(CH2)n硫、羟基羰基、氨基羰基、C1-4烷基羰基、Ar2羰基、C1-4烷氧基羰基、Ar2(CH2)n羰基、氨基羰基氧、C1-4烷基羰基氧、Ar2羰基氧、Ar2(CH2)n羰基氧、C1-4烷氧基羰基(CH2)n氧、单或二(C1-4烷基)氨基羰基、单或二(C1-4烷基)氨基羰基氧、氨基磺酰基、单或二(C1-4烷基)氨基磺酰基或选自吡咯烷基、吡咯基、二氢吡咯基、咪唑基、三唑基、哌啶基、高哌啶基、哌嗪基、吗啉基、硫代吗啉基、1-氧代-硫代吗啉基、1,1-二氧代-硫代吗啉基、吡啶基和四氢吡啶基的杂环,其中所述的每个杂环可选择性地被羰基或C1-6烷基取代;G为直接键或可选择性取代的C1-10亚烷基;R1为Ar1或单环或双环杂环;R2a和R3a中的一个是C1-6烷基,另一个是氢;如果R2a不同于氢,则R2b为氢或C1-6烷基,R3b为氢;如果R3a不同于氢,则R3b为氢或C1-6烷基,R2b为氢;t为1、2或3;Ar1为苯基或取代苯基;Ar2为苯基或取代苯基。本发明还涉及它们的制备方法和包含它们的组合物,以及它们作为药物的用途。
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(甲基3-(二甲基氨基)-2-苯基-2H-azirene-2-羧酸乙酯) (±)-盐酸氯吡格雷 (±)-丙酰肉碱氯化物 (d(CH2)51,Tyr(Me)2,Arg8)-血管加压素 (S)-(+)-α-氨基-4-羧基-2-甲基苯乙酸 (S)-阿拉考特盐酸盐 (S)-赖诺普利-d5钠 (S)-2-氨基-5-氧代己酸,氢溴酸盐 (S)-2-[3-[(1R,2R)-2-(二丙基氨基)环己基]硫脲基]-N-异丙基-3,3-二甲基丁酰胺 (S)-1-(4-氨基氧基乙酰胺基苄基)乙二胺四乙酸 (S)-1-[N-[3-苯基-1-[(苯基甲氧基)羰基]丙基]-L-丙氨酰基]-L-脯氨酸 (R)-乙基N-甲酰基-N-(1-苯乙基)甘氨酸 (R)-丙酰肉碱-d3氯化物 (R)-4-N-Cbz-哌嗪-2-甲酸甲酯 (R)-3-氨基-2-苄基丙酸盐酸盐 (R)-1-(3-溴-2-甲基-1-氧丙基)-L-脯氨酸 (N-[(苄氧基)羰基]丙氨酰-N〜5〜-(diaminomethylidene)鸟氨酸) (6-氯-2-吲哚基甲基)乙酰氨基丙二酸二乙酯 (4R)-N-亚硝基噻唑烷-4-羧酸 (3R)-1-噻-4-氮杂螺[4.4]壬烷-3-羧酸 (3-硝基-1H-1,2,4-三唑-1-基)乙酸乙酯 (2S,3S,5S)-2-氨基-3-羟基-1,6-二苯己烷-5-N-氨基甲酰基-L-缬氨酸 (2S,3S)-3-((S)-1-((1-(4-氟苯基)-1H-1,2,3-三唑-4-基)-甲基氨基)-1-氧-3-(噻唑-4-基)丙-2-基氨基甲酰基)-环氧乙烷-2-羧酸 (2S)-2,6-二氨基-N-[4-(5-氟-1,3-苯并噻唑-2-基)-2-甲基苯基]己酰胺二盐酸盐 (2S)-2-氨基-3-甲基-N-2-吡啶基丁酰胺 (2S)-2-氨基-3,3-二甲基-N-(苯基甲基)丁酰胺, (2S,4R)-1-((S)-2-氨基-3,3-二甲基丁酰基)-4-羟基-N-(4-(4-甲基噻唑-5-基)苄基)吡咯烷-2-甲酰胺盐酸盐 (2R,3'S)苯那普利叔丁基酯d5 (2R)-2-氨基-3,3-二甲基-N-(苯甲基)丁酰胺 (2-氯丙烯基)草酰氯 (1S,3S,5S)-2-Boc-2-氮杂双环[3.1.0]己烷-3-羧酸 (1R,4R,5S,6R)-4-氨基-2-氧杂双环[3.1.0]己烷-4,6-二羧酸 齐特巴坦 齐德巴坦钠盐 齐墩果-12-烯-28-酸,2,3-二羟基-,苯基甲基酯,(2a,3a)- 齐墩果-12-烯-28-酸,2,3-二羟基-,羧基甲基酯,(2a,3b)-(9CI) 黄酮-8-乙酸二甲氨基乙基酯 黄荧菌素 黄体生成激素释放激素 (1-5) 酰肼 黄体瑞林 麦醇溶蛋白 麦角硫因 麦芽聚糖六乙酸酯 麦根酸 麦撒奎 鹅膏氨酸 鹅膏氨酸 鸦胆子酸A甲酯 鸦胆子酸A 鸟氨酸缩合物