N-(对甲苯)氨基甲酸乙酯 | 5255-66-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(对甲苯)氨基甲酸乙酯
• 英文名称: ethyl p-tolylcarbamate
• 英文别名: ethyl N-(4-methylphenyl)carbamate；N-p-tolylcarbamic acid ethyl ester
• CAS: 5255-66-3
• 化学式: C₁₀H₁₃NO₂
• mdl: MFCD00089001
• 分子量: 179.219
• InChiKey: RGLJNFKWUYDVBI-UHFFFAOYSA-N

物化性质

• 保留指数：
  1495;1496;1500

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  N-(对甲苯)氨基甲酸乙酯 在 phosphorus pentoxide 作用下， 生成 对甲苯异氰酸酯
  参考文献：
  名称：

  Trichosporon asahii-induced asthma in a family with Japanese summer-type hypersensitivity pneumonitis

  摘要：

  Background: Trichosporon species frequently induce summer-type hypersensitivity pneumonitis (SHP), which is the most prevalent type of hypersensitivity pneumonitis (HP) in Japan, but have not been reported to induce asthma.Objective: Evaluation of a case of asthma induced by Trichosporon asahii.Methods and Results: This report describes a 46-year-old Japanese man who developed asthma induced by T. asahii, following symptoms of HP attributable to the same pathogen, in a case of familial occurrence of SHP. This patient lacked typical findings of HP in his radiograph but had an elevated level of eosinophils in his bronchoalveolar lavage fluid. Open lung biopsy, however, revealed typical pathologic findings of HP when he was free of asthmatic symptoms. His serum was also positive for anti-T. asahii antibody, as are the sera of SHP patients. Nevertheless, provocation tests, including returning home and inhalations of T. asahii antigen, reproduced asthmatic features such as airway hyperresponsiveness and reversible bronchoobstruction, but not the features of HP. A skin test with the same antigen also evoked an immediate allergic reaction. An IgE mechanism was suspected but could not be proven by radioallergosorbent test. The patient's son and daughter displayed typical features of SHP, associated with compatible results in their radiographs, bronchoalveolar lavage fluid analysis, serologic and pathologic examinations, and provocation and skin tests.Conclusions: To our knowledge, this is the first case of extrinsic asthma, and of coexistent asthma and HP, induced by T. asahii. The patient initially displayed symptoms typical of SHP, which were subsequently replaced by more typical asthmatic symptoms.

  DOI：

  10.1016/s1081-1206(10)62018-2
• 作为产物：
  描述：

  4-硝基甲苯 以95%的产率得到N-(对甲苯)氨基甲酸乙酯
  参考文献：
  名称：

  Process for producing an aromatic urethane

  摘要：

  通过将芳香族硝基化合物、至少含有一个羟基的有机化合物和一氧化碳在含有(1)钯、钌、铑或其化合物的(2)路易斯酸和(3)叔胺的催化剂存在下相互作用，可以获得高产率的芳香族脲烷，而不涉及不锈钢反应器的腐蚀。例如，将2,4-二硝基甲苯、乙醇和一氧化碳放入SUS-32反应器中，在含有(1)5%钯/碳、(2)氯化铁和(3)吡啶的催化剂存在下相互作用，可以获得2,4-二乙基二碳酸甲苯，而不会腐蚀反应器。反应完成后，将催化剂和反应产物从反应系统中分离出来；例如，首先分离不溶性催化剂，然后将反应溶液冷却，例如，到室温，以结晶形式分离出反应产物，随后通过过滤分离出晶体。然后，通过在加压的一氧化碳气氛下向所得滤液中加入新鲜的2,4-二硝基甲苯和乙醇以及分离的催化剂，可以重复反应。通过这种方式重复反应，可以获得纯度为98%，产率为90%的2,4-二乙基二碳酸甲苯。

  公开号：

  US04186269A1

文献信息

• Power- and structure-variable fluorinating agents. The N-fluoropyridinium salt system
  作者：Teruo Umemoto、Shinji Fukami、Ginjiro Tomizawa、Kikuko Harasawa、Kosuke Kawada、Kyoichi Tomita

  DOI：10.1021/ja00179a047

  日期：1990.11

  N-Fluoropyridinium salts provide a new system of fluorinating agents by which a wide range of nucleophilic substrates differing in reactivity can be fluorinated due to the varying degree of fluorinating power and also fluorinated very selectively through structural alteration. The scope of selective fluorination should be broadened considerably on the basis of the present results. The N-fluoropyridinium

  N-氟吡啶鎓盐提供了一种新的氟化剂系统，通过该系统，由于氟化能力的不同程度，反应性不同的各种亲核底物可以被氟化，并且还可以通过结构改变非常有选择性地氟化。在现有结果的基础上，选择性氟化的范围应该大大拓宽。因此，N-氟吡啶鎓盐系统应该可以制备许多有用的有机氟化合物
• Halogenation Using Quaternary Ammonium Polyhalides. IX. One-Step Syntheses of Acylureas and Carbamates from Amides by Use of Tetrabutylammonium Tribromide and DBU
  作者：Shizuo Fujisaki、Kazushi Tomiyasu、Akiko Nishida、Shoji Kajigaeshi

  DOI：10.1246/bcsj.61.1401

  日期：1988.4

  The reaction of amides with tetrabutylammonium tribromide (TBA Br3) (0.5 equiv) and DBU (one equiv) in dichloromethane at room temperature gave N-substituted acylureas in fairly good yields. In the...

  在室温下，酰胺与四丁基三溴化铵 (TBA Br3)（0.5 当量）和 DBU（1 当量）在二氯甲烷中的反应以相当好的产率得到 N-取代的酰基脲。在里面...
• SUBSTITUTED BENZAMIDES
  申请人：Groebke Zbinden Katrin

  公开号：US20110152245A1

  公开（公告）日：2011-06-23

  The invention relates to compounds of formula wherein R, R 1 , R 2 , X, and Y are as defined herein and to a pharmaceutically suitable acid addition salt thereof. Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds can be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

  该发明涉及以下式的化合物 其中R、R1、R2、X和Y如本文所定义，并且其药学上适宜的酸盐。 式I的化合物对痕量胺相关受体（TAARs）具有良好的亲和力，特别是对TAAR1。这些化合物可用于治疗抑郁症、焦虑障碍、双相情感障碍、注意缺陷多动障碍（ADHD）、与压力有关的障碍、如精神分裂症的精神障碍、如帕金森病的神经疾病、如阿尔茨海默病的神经退行性疾病、癫痫、偏头痛、高血压、物质滥用和代谢性障碍，如进食障碍、糖尿病、糖尿病并发症、肥胖症、血脂异常、能量消耗和吸收障碍、体温稳态障碍、睡眠和昼夜节律障碍，以及心血管疾病。
• The Platinum Complex Catalyzed Reductive<i>N</i>-Carbonylation of Nitroarenes to the Carbamates
  作者：Yoshihisa Watanabe、Yasushi Tsuji、Ryo Takeuchi、Naoki Suzuki

  DOI：10.1246/bcsj.56.3343

  日期：1983.11

  chloride and titanium(IV) chloride could be used as Lewis acids in place of tin(IV) chloride. Various nitroarenes were transformed into corresponding carbamate in moderate to excellent yields with the platinum catalyst.

  铂催化剂与三苯基膦、氯化锡 (IV) 和三乙胺结合，在 180 °C 和 60 kg cm-2 的一氧化碳下，对硝基芳烃在乙醇中的还原性 N-羰基化显示出高活性。由硝基苯以83%的产率获得苯基氨基甲酸乙酯。氯化铁 (III)、氯化铝和氯化钛 (IV) 可用作路易斯酸代替氯化锡 (IV)。在铂催化剂的作用下，各种硝基芳烃以中等至极好的收率转化为相应的氨基甲酸酯。
• An exceptionally mild, catalytic homogeneous method for the conversion of amines into carbamate esters
  作者：Howard Alper、Frederick W. Hartstock

  DOI：10.1039/c39850001141

  日期：——

  Aromatic amines react at room temperature and atmospheric pressure with carbon monoxide, oxygen, alcohols, and hydrochloric acid, with palladium chloride as the catalyst and copper(II) chloride as re-oxidant to give carbamate esters in fair to quantitative yields.

  芳族胺在室温和大气压下与一氧化碳，氧气，醇和盐酸反应，以氯化钯为催化剂，氯化铜（II）为再氧化剂，以合理的定量收率得到氨基甲酸酯。

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