4-(吗啉-4-羰基)苯甲醛 | 58287-80-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 4-(吗啉-4-羰基)苯甲醛
• 英文名称: 4-(morpholine-4-carbonyl)benzaldehyde
• 英文别名: 4-(morpholin-4-ylcarbonyl)benzaldehyde
• CAS: 58287-80-2
• 化学式: C₁₂H₁₃NO₃
• mdl: MFCD09758996
• 分子量: 219.24
• InChiKey: WVDVJQSVTBHGQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  4-(吗啉-4-羰基)苯甲醛 在 三氟乙酸 、 2,3-二氯-5,6-二氰基-1,4-苯醌 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 反应 7.83h， 生成 methyl 3-[2,2-difluoro-12-(3-methoxy-3-oxoprop-1-enyl)-8-[4-(morpholine-4-carbonyl)phenyl]-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl]prop-2-enoate
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS WITH PHOTOLUMINESCNCE PROPERTIES AND APPLICATIONS THEREOF
  [FR] NOUVEAUX COMPOSÉS AYANT DES PROPRIÉTÉS DE PHOTOLUMINESCENCE ET APPLICATIONS ASSOCIÉES

  摘要：

  公开号：

  WO2012118444A9
• 作为产物：
  描述：

  4-(吗啉-4-羰基)溴苯 、 9-methyl-9H-fluorene-9-carbonyl chloride 在 dichloro(cycloocta-1,5-diene)palladium (II) 、 N-甲基二环己基胺 、 potassium formate 、 四丁基碘化铵 、 tricyclohexylphosphine tetrafluoroborate 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 tri tert-butylphosphoniumtetrafluoroborate 作用下， 反应 18.0h， 以73%的产率得到4-(吗啉-4-羰基)苯甲醛
  参考文献：
  名称：

  Reductive Carbonylation of Aryl Halides Employing a Two-Chamber Reactor: A Protocol for the Synthesis of Aryl Aldehydes Including ¹³C- and D-Isotope Labeling

  摘要：

  A protocol has been developed for conducting the palladium-catalyzed reductive carbonylation of aryl iodides and bromides using 9-methylfluorene-9-carbonyl chloride (COgen) as a source of externally delivered carbon monoxide in a sealed two-chamber system (COware), and potassium formate as the in situ hydride source. The method is tolerant to a wide number Of functional groups positioned on the aromatic ring, and it can be exploited for the isotope labeling of the aldehyde group. Hence, reductive carbonylations run with (13)COgen provide a facile access to C-13-labeled aromatic aldehydes, whereas with DCO2K, the aldehyde is specifically labeled with deuterium. Two examples of double isotopic labeling are also demonstrated. Finally, the method was applied to the specific carbon-13 labeling of the beta-amyloid binding compound, florbetaben.

  DOI：

  10.1021/jo400741t

文献信息

• COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF
  申请人：WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.

  公开号：US20200190066A1

  公开（公告）日：2020-06-18

  It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.

  该内容涉及作为自噬调节剂的化合物及其制备和使用方法，具体提供了一类具有通用公式(I)的化合物，或其药用可接受盐，这是一种自噬调节剂，特别是哺乳动物ATG8同源物调节剂。
• Mesoporous poly-melamine-formaldehyde stabilized palladium nanoparticle (Pd@mPMF) catalyzed mono and double carbonylation of aryl halides with amines
  作者：Rostam Ali Molla、Md. Asif Iqubal、Kajari Ghosh、Anupam Singha Roy、Kamaluddin Kamaluddin、Sk. Manirul Islam

  DOI：10.1039/c4ra07554d

  日期：——

  A new mesoporous polymer stabilized Pd nano (mPMF–Pd⁰) has been synthesized and well characterized. The catalytic performance of this complex has been tested for mono and double carbonylation of aryl halides with amines.

  一种新的介孔聚合物稳定的Pd纳米(mPMF-Pd^0)已经合成并进行了良好的表征。该复合物的催化性能已经用于芳基卤化物与胺的单和双羰基化反应的测试。
• [EN] HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES<br/>[FR] COMPOSÉS À PETITES MOLÉCULES MIMÉTIQUES DES FACTEURS DE CROISSANCE HÉMATOPOÏÉTIQUE ET LEURS UTILISATIONS
  申请人：LIGAND PHARM INC

  公开号：WO2011046954A1

  公开（公告）日：2011-04-21

  The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.

  目前的实施例涉及具有生理效应的化合物，例如激活造血生长因子受体。目前的实施例还涉及利用这些化合物来治疗各种疾病、疾病和疾患，如造血状况和疾病。
• A synthesis of α-amino acids via direct reductive carboxylation of imines with carbon dioxide
  作者：Ajay A. Sathe、Douglas R. Hartline、Alexander T. Radosevich

  DOI：10.1039/c3cc42057d

  日期：——

  A method for the synthesis of alpha-amino acids by direct reductive carboxylation of aromatic imines with CO2 is described. The protocol employs readily available commercial reagents and serves as a one-step alternative to the Strecker synthesis.

  描述了通过用CO 2对芳族亚胺进行直接还原羧化来合成α-氨基酸的方法。该方案采用现成的市售试剂，并作为Strecker合成的一步替代品。
• COMPOUNDS AND METHOD OF USE
  申请人：Ferro Therapeutics, Inc.

  公开号：US20190263802A1

  公开（公告）日：2019-08-29

  This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.

  本公开涉及具有诱导铁死亡活性的化合物，一种使用这些化合物治疗癌症患者的方法，以及与第二种治疗药物的联合治疗。