3-(benzo[d]thiazol-2-yl)-7-(isopropyl(prop-2-ynyl)amino)-2H-chromen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-(benzo[d]thiazol-2-yl)-7-(isopropyl(prop-2-ynyl)amino)-2H-chromen-2-one
• 英文别名: 3-(1,3-benzothiazol-2-yl)-7-[propan-2-yl(prop-2-ynyl)amino]chromen-2-one
• 化学式: C₂₂H₁₈N₂O₂S
• 分子量: 374.463
• InChiKey: CAWQJIPAOMMXLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  70.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  copper(ll) sulfate pentahydrate 、 3-(benzo[d]thiazol-2-yl)-7-(isopropyl(prop-2-ynyl)amino)-2H-chromen-2-one 、 4-methoxy benzyl 4-((3,4,5-tris(2-(2-(2-azidoethoxy)ethoxy) ethoxy)benzamido)methyl)benzoate 、 sodium ascorbate 以 二氯甲烷 、 水 为溶剂， 以60%的产率得到4-methoxybenzyl 4-((3,4,5-tris(2-(2-((4-(((3-(benzo[d]thiazol-2-yl)-2-oxo-2H-chromen-7-yl)(isopropyl)amino)methyl)-1H-1,2,3-triazol-1-yl)methoxy)ethoxy) ethoxy)benzamido)methyl)benzoate
  参考文献：
  名称：

  MULTI-FLUORESCENT SUBSTANCE INCLUDING NOVEL COUMARIN DERIVATIVE, AND LED LIGHT SOURCE-BASED MICROFLUORESCENT QUANTITATIVE BIOSENSOR FOR DIAGNOSIS USING SAME

  摘要：

  本发明涉及一种新型香豆素衍生物，一种制备该衍生物的方法，以及包括多个香豆素衍生物并能够利用LED光源发射光的多荧光物质。根据本发明的新型香豆素衍生物多荧光物质具有512纳米至590纳米的最佳发射波长带，因此能够有效提高信号强度和稳定性，因为可以利用LED光源进行光发射。此外，与相关技术中已知的香豆素荧光物质相比，由于一个分子具有多个荧光物质，因此表现出更高的荧光反应性，而且解决了香豆素荧光物质可能结合到抗体的抗原结合位点的问题，因为即使少量的荧光物质分子结合到抗体上，也可以进行荧光检测。此外，根据本发明的新型香豆素衍生物多荧光物质适用于作为基于LED的微荧光定量生物传感器用于诊断的荧光联结免疫吸附试验（FLISA）和快速荧光免疫层析试验（FICT），因此，可以快速和定量地分析疟疾等疾病。

  公开号：

  US20140350227A1
• 作为产物：
  描述：

  哌啶 、 2-(2-苯并噻唑)乙酸乙酯 以 乙醇 为溶剂， 生成 3-(benzo[d]thiazol-2-yl)-7-(isopropyl(prop-2-ynyl)amino)-2H-chromen-2-one
  参考文献：
  名称：

  MULTI-FLUORESCENT SUBSTANCE INCLUDING NOVEL COUMARIN DERIVATIVE, AND LED LIGHT SOURCE-BASED MICROFLUORESCENT QUANTITATIVE BIOSENSOR FOR DIAGNOSIS USING SAME

  摘要：

  本发明涉及一种新型香豆素衍生物，一种制备该衍生物的方法，以及包括多个香豆素衍生物并能够利用LED光源发射光的多荧光物质。根据本发明的新型香豆素衍生物多荧光物质具有512纳米至590纳米的最佳发射波长带，因此能够有效提高信号强度和稳定性，因为可以利用LED光源进行光发射。此外，与相关技术中已知的香豆素荧光物质相比，由于一个分子具有多个荧光物质，因此表现出更高的荧光反应性，而且解决了香豆素荧光物质可能结合到抗体的抗原结合位点的问题，因为即使少量的荧光物质分子结合到抗体上，也可以进行荧光检测。此外，根据本发明的新型香豆素衍生物多荧光物质适用于作为基于LED的微荧光定量生物传感器用于诊断的荧光联结免疫吸附试验（FLISA）和快速荧光免疫层析试验（FICT），因此，可以快速和定量地分析疟疾等疾病。

  公开号：

  US20140350227A1

文献信息

• Multi-fluorescent substance including novel coumarin derivative, and LED light source-based microfluorescent quantitative biosensor for diagnosis using same
  申请人：Park Hyun

  公开号：US09354234B2

  公开（公告）日：2016-05-31

  The present invention relates to a novel coumarin derivative, to a method for preparing the same, and a multi-fluorescent substance that includes a plurality of the coumarin derivatives and is able to emit light using an LED light source. A novel coumarin derivative multi-fluorescent substance according to the present invention has an optimal emission wavelength band of 512 nm to 590 nm and thereby is effective in improving a signal intensity and stability since light emission using an LED light source is possible. In addition, higher fluorescence reactivity is exhibited compared to coumarin fluorescent substances known in the related arts since one molecule has a plurality of fluorescent substances, and the problem of the coumarin fluorescent substance possibly binding to a binding site of the antigen of the antibody is solved since fluorescence detection is possible even when a minimum number of fluorescent substance molecules bind to an antibody. Moreover, the novel coumarin derivative multi-fluorescent substance according to the present invention is suitably used in a fluorescent-linked immunosorbent assay (FLISA) and a rapid fluorescent immunochromatographic test (FICT) as an LED-based microfluorescent quantitative biosensor for diagnosis, therefore, diseases such as malaria may be rapidly and quantitatively analyzed.

  本发明涉及一种新型香豆素衍生物、其制备方法以及包含多种香豆素衍生物的多荧光物质，该多荧光物质能够使用LED光源发光。本发明的新型香豆素衍生物多荧光物质具有512nm至590nm的最佳发射波长带，因此能够通过使用LED光源发光来有效提高信号强度和稳定性。此外，与相关技术中已知的香豆素荧光物质相比，由于一种分子具有多种荧光物质，因此表现出更高的荧光反应性，并且即使最少量的荧光物质分子与抗体结合，也可以进行荧光检测，从而解决了香豆素荧光物质可能与抗体的抗原结合位点结合的问题。此外，本发明的新型香豆素衍生物多荧光物质可作为基于LED的微荧光定量生物传感器，在荧光联合免疫吸附测定（FLISA）和快速荧光免疫层析试验（FICT）中得到适当使用，因此，可以快速和定量地分析疟疾等疾病。
• US9354234B2
  申请人：——

  公开号：US9354234B2

  公开（公告）日：2016-05-31
• [EN] MULTI-FLUORESCENT SUBSTANCE INCLUDING NOVEL COUMARIN DERIVATIVE, AND LED LIGHT SOURCE-BASED MICROFLUORESCENT QUANTITATIVE BIOSENSOR FOR DIAGNOSIS USING SAME<br/>[FR] SUBSTANCE MULTIFLUORESCENTE CONTENANT UN NOUVEAU DÉRIVÉ DE COUMARINE, ET BIOCAPTEUR QUANTITATIF MICROFLUORESCENT À VISÉE DIAGNOSTIQUE BASÉ SUR UNE SOURCE LUMINEUSE DE TYPE LED L'UTILISANT
  申请人：WONKWANG UNIV CT IND ACAD COOP

  公开号：WO2013051769A1

  公开（公告）日：2013-04-11

  본 발명은 신규한 코마린 유도체, 이의 제조방법 및 상기 코마린 유도체를 다수 포함하는 LED 광원에 의해 발광 가능한 다중 형광체에 관한 것이다. 본 발명에 따른 신규한 코마린 유도체 다중형광체는 512 nm 내지 590 nm의 최적 여기 파장범위를 가지므로 LED 광원에 의해 발광이 가능하므로 신호의 세기 및 안정성이 개선된 효과를 나타낸다. 또한, 공지된 코마린 형광체와 비교하여 한 분자가 다수의 형광체를 가지게 되는 바. 높은 형광 반응을 나타내며, 항체에 최소한의 형광체 분자만 결합하더라도 형광 검출이 가능한바, 코마린 형광체가 항체의 항원과 결합하는 부위에 결합될 수 있는 문제를 해결하였다. 또한, 본 발명에 따른 신규한 코마린 유도체 다중형광체는 LED 기반 진단용 미세형광정량 바이오센서로서 형광표지면역분석법(FLISA) 및 신속 형광 면역크로마토그래피법(FICT)에 적합하게 사용될 수 있는바 말라리아 등의 질환을 신속하고 정량적으로 분석할 수 있다.
• MULTI-FLUORESCENT SUBSTANCE INCLUDING NOVEL COUMARIN DERIVATIVE, AND LED LIGHT SOURCE-BASED MICROFLUORESCENT QUANTITATIVE BIOSENSOR FOR DIAGNOSIS USING SAME
  申请人：Park Hyun

  公开号：US20140350227A1

  公开（公告）日：2014-11-27

  The present invention relates to a novel coumarin derivative, to a method for preparing the same, and a multi-fluorescent substance that includes a plurality of the coumarin derivatives and is able to emit light using an LED light source. A novel coumarin derivative multi-fluorescent substance according to the present invention has an optimal emission wavelength band of 512 nm to 590 nm and thereby is effective in improving a signal intensity and stability since light emission using an LED light source is possible. In addition, higher fluorescence reactivity is exhibited compared to coumarin fluorescent substances known in the related arts since one molecule has a plurality of fluorescent substances, and the problem of the coumarin fluorescent substance possibly binding to a binding site of the antigen of the antibody is solved since fluorescence detection is possible even when a minimum number of fluorescent substance molecules bind to an antibody. Moreover, the novel coumarin derivative multi-fluorescent substance according to the present invention is suitably used in a fluorescent-linked immunosorbent assay (FLISA) and a rapid fluorescent immunochromatographic test (FICT) as an LED-based microfluorescent quantitative biosensor for diagnosis, therefore, diseases such as malaria may be rapidly and quantitatively analyzed.

  本发明涉及一种新型香豆素衍生物，一种制备该衍生物的方法，以及包括多个香豆素衍生物并能够利用LED光源发射光的多荧光物质。根据本发明的新型香豆素衍生物多荧光物质具有512纳米至590纳米的最佳发射波长带，因此能够有效提高信号强度和稳定性，因为可以利用LED光源进行光发射。此外，与相关技术中已知的香豆素荧光物质相比，由于一个分子具有多个荧光物质，因此表现出更高的荧光反应性，而且解决了香豆素荧光物质可能结合到抗体的抗原结合位点的问题，因为即使少量的荧光物质分子结合到抗体上，也可以进行荧光检测。此外，根据本发明的新型香豆素衍生物多荧光物质适用于作为基于LED的微荧光定量生物传感器用于诊断的荧光联结免疫吸附试验（FLISA）和快速荧光免疫层析试验（FICT），因此，可以快速和定量地分析疟疾等疾病。