benzoyl-DL-serine | 4582-71-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzoyl-DL-serine
• 英文别名: (dl)-N-Benzoylserine；N-(benzoyl)serine；N-benzoyl-DL-serine；N-benzoyl-serine；N-Benzoyl-DL-serin；N-Benzoyl-serin；3-Hydroxy-2-(phenylformamido)propanoic acid；2-benzamido-3-hydroxypropanoic acid
• CAS: 4582-71-2
• 化学式: C₁₀H₁₁NO₄
• mdl: MFCD01570456
• 分子量: 209.202
• InChiKey: MWCDMTCWMZHVAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  benzoyl-DL-serine 生成 L-丝氨酸
  参考文献：
  名称：

  Kameda et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1958, vol. 78, p. 767

  摘要：

  DOI：
• 作为产物：
  描述：

  2-benzoylamino-3-oxo-propionic acid ethyl ester 在 sodium hydroxide 、 乙醚 、 aluminium amalgam 作用下， 生成 benzoyl-DL-serine
  参考文献：
  名称：

  Erlenmeyer jun.; Stoop, Justus Liebigs Annalen der Chemie, 1904, vol. 337, p. 256

  摘要：

  DOI：

文献信息

• Reactivity of α-Amino Acids in the Reaction with Esters in Aqueous–1,4-Dioxane Media
  作者：L. B. Kochetova、T. P. Kustova、L. V. Kuritsyn

  DOI：10.1134/s1070363218010127

  日期：2018.1

  The kinetics of the reaction of a series of α-amino acids with 4-nitrophenyl acetate, 4-nitrophenyl benzoate, and 2,4,6-trinitrophenyl benzoate in aqueous 1,4-dioxane medium has been studied. Kinetics of the reactions involving 4-nitrophenyl acetate and 2,4,6-trinitrophenyl benzoate has complied with the Brønsted dependence and revealed linear correlation between rate constant logarithm and the energy

  研究了一系列α-氨基酸与4-硝基苯基乙酸酯，4-硝基苯基苯甲酸酯和2,4,6-三硝基苯基苯甲酸酯在1,4-二恶烷水溶液中的反应动力学。涉及乙酸4-硝基苯酯和2,4,6-三硝基苯甲酸苯酯的反应动力学符合布朗斯台德依赖性，并揭示了速率常数对数与α-氨基酸阴离子前沿轨道的能量差之间的线性关系。
• [EN] GRANZYME B DIRECTED IMAGING AND THERAPY<br/>[FR] IMAGERIE DU GRANZYME B ET THÉRAPIE DIRIGÉES CONTRE LE GRANZYME B
  申请人：CYTOSITE BIOPHARMA INC

  公开号：WO2019160916A1

  公开（公告）日：2019-08-22

  Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

  本文提供了用于成像Granzyme B的杂环化合物。还提供了成像Granzyme B的方法、联合疗法以及包含Granzyme B成像试剂的试剂盒。
• Gemischte Anhydride aus Carbobenzoxy-Aminosäuren und Chlorameisensäure zur Veresterung von aromatischen und aliphatischen Hydroxyl-Verbindungen
  作者：M. Brenner、J. P. Zimmermann、P. Quitt、W. Schneider、A. Hartmann

  DOI：10.1002/hlca.19570400315

  日期：——

  Die Einführung des N-Cbzo-α-Aminosäure-Restes in alkoholische und phenolische Hydroxylgruppen erfolgt einfach und zuverlässig mit Hilfe von Phosgen bei tiefen Temperaturen. Die „Phosgenmethode” wird in einer Reihe von Beispielen beschrieben.

  N-Cbzo-α-Aminosäure-Restes在醇和酚醛中的反应 死于“艾诺尔·里贝·冯·贝斯皮伦·贝希里本”的“光致发光二极管”。
• PREVENTING OR AMELIORATING AGENT FOR PIGMENTATION
  申请人：Saitoh Yuko

  公开号：US20120258063A1

  公开（公告）日：2012-10-11

  An object is to provide an external preparation for skin preferably usable to prevent or ameliorate pigmentation. The object is achieved by providing a preventing or ameliorating agent for pigmentation, consisting of a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof, and an external preparation for skin containing the same as a component: [wherein R 1 represents an unsubstituted aromatic group or an aromatic group having any substituent; R 2 represents a hydrogen atom, a linear chain or branched chain alkyl group having a number of carbon atom or atoms of 1 to 4, or an acyl group having a linear or branched alkyl chain having a number of carbon atom or atoms of 1 to 4; and R 3 represents a hydrogen atom or a linear chain or branched chain alkyl group having a number of carbon atom or atoms of 1 to 4.]

  本发明旨在提供一种外用制剂，特别是用于预防或改善色素沉着的皮肤外用制剂。本发明通过提供一种预防或改善色素沉着的制剂，该制剂包括以下一般式（1）所表示的化合物，其异构体和/或药学上可接受的盐，并且包含该化合物作为组分的皮肤外用制剂，从而实现上述目的: [其中R1表示未取代的芳香基或具有任何取代基的芳香基; R2表示氢原子，具有1至4个碳原子的线性链或支链烷基，或具有1至4个碳原子的线性或支链烷基链的酰基; R3表示氢原子或具有1至4个碳原子的线性链或支链烷基。]
• The UDPase activity of the Kluyveromyces lactis Golgi GDPase has a role in uridine nucleotide sugar transport into Golgi vesicles
  作者：M. D. Lopez-Avalos、D. Uccelletti、C. Abeijon、C. B. Hirschberg

  DOI：10.1093/glycob/11.5.413

  日期：2001.5.1

  In Saccharomyces cerevisiae a Golgi lumenal GDPase (ScGda1p) generates GMP, the antiporter required for entry of GDP-mannose, from the cytosol, into the Golgi lumen. Scgda1 deletion strains have severe defects in N- and O-mannosylation of proteins and glycosphingolipids. ScGda1p has also significant UDPase activity even though S. cerevisiae does not utilize uridine nucleotide sugars in its Golgi lumen. Kluyveromyces lactis, a species closely related to S. cerevisiae, transports UDP-N-acetylglucosamine into its Golgi lumen, where it is the sugar donor for terminal N-acetylglucosamine of the mannan chains. We have identified and cloned a K. lactis orthologue of ScGda1p. KlGda1p is 65% identical to ScGda1p and shares four apyrase conserved regions with other nucleoside diphosphatases. KlGda1p has UDPase activity as ScGda1p. Transport of both GDP-mannose, and UDP-GlcNAc was decreased into Golgi vesicles from Klgda1 null mutants, demonstrating that KlGda1p generates both GMP and UMP required as antiporters for guanosine and uridine nucleotide sugar transport into the Golgi lumen. Membranes from Klgda1 null mutants showed inhibition of glycosyltransferases utilizing uridine- and guanosine-nucleotide sugars, presumably due to accumulation of nucleoside diphosphates because the inhibition could be relieved by addition of apyrase to the incubations. KlGDA1 and ScGDA1 restore the wild-type phenotype of the other yeast gda1 deletion mutant. Surprisingly, KlGDA1 has only a role in O-glycosylation in K. lactis but also complements N-glycosylation defects in S. cerevisiae. Deletion mutants of both genes have altered cell wall stability and composition, demonstrating a broader role for the above enzymes.

  在酿酒酵母（Saccharomyces cerevisiae）中，高尔基体腔内 GDP 酶（ScGDA1p）生成 GMP，这是 GDP-甘露糖从细胞质进入高尔基体腔所需的反转运体。ScgDA1 基因缺失株在蛋白质和糖磷脂的 N- 和 O-mannosyl 化方面存在严重缺陷。尽管 S. cerevisiae 在高尔基体腔内不利用尿苷核苷酸糖，但 ScGDA1p 也具有显著的尿苷核苷酸酶活性。乳酸克鲁维酵母菌（Kluyveromyces lactis）是一种与麦角菌（S. cerevisiae）亲缘关系很近的菌种，它将 UDP-N-乙酰葡糖胺转运到高尔基管腔中，作为甘露聚糖链末端 N-乙酰葡糖胺的供糖体。我们发现并克隆了 K. lactis 的 ScGDA1p 同源物。KlGDA1p与ScGDA1p有65%的相同之处，并与其他核苷二磷酸酶共享四个apyrase保守区。KlGDA1p 与 ScGDA1p 一样具有 UDP 酶活性。在 KlgDA1 空缺突变体的高尔基体囊泡中，GDP-甘露糖和 UDP-GlcNAc 的转运都有所减少，这表明 KlGDA1p 产生的 GMP 和 UMP 都是鸟苷酸和尿苷核苷酸糖转运到高尔基体内腔所需的反转运体。来自 KlgDA1 空缺突变体的膜显示出对利用尿苷和鸟苷酸核苷酸糖的糖基转移酶的抑制，这可能是由于核苷二磷酸盐的积累，因为在培养液中加入 apyrase 可以缓解抑制作用。KlGDA1 和 ScGDA1 恢复了另一种酵母 gDA1 缺失突变体的野生型表型。令人惊讶的是，KlGDA1在乳酸酵母中只起O-糖基化作用，但在酿酒酵母中却能补充N-糖基化缺陷。这两个基因的缺失突变体都改变了细胞壁的稳定性和组成，表明上述酶具有更广泛的作用。