bis[2-hydroxy-3-methylphenyl]methane | 13747-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis[2-hydroxy-3-methylphenyl]methane
• 英文别名: 2,2'-methylenebis(6-methylphenol)；6,6'-dimethyl-2,2'-methanediyl-di-phenol；6,6'-Dimethyl-2,2'-methandiyl-di-phenol；Bis-(2-hydroxy-3-methyl-phenyl)-methan；2,2'-methylene bis-6-methyl phenol；2,2'-Methanediylbis(6-methylphenol)；2-[(2-hydroxy-3-methylphenyl)methyl]-6-methylphenol
• CAS: 13747-35-8
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: XACVRCGRFRDJTE-UHFFFAOYSA-N

物化性质

• 熔点：
  122-123 °C(Solv: ethanol, 50% (64-17-5))
• 沸点：
  377.4±37.0 °C(Predicted)
• 密度：
  1.151±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  bis[2-hydroxy-3-methylphenyl]methane 在 镍 氢氧化钾 、 氢溴酸 、 氢气 、 zinc(II) carbonate 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 25.0~60.0 ℃ 、7.73 kPa 条件下， 反应 16.0h， 生成 4,4'-bis(3-tert-butyl-4-hydroxybenzyl)-6,6'-dimethyl-2,2'-methanediyldiphenol
  参考文献：
  名称：

  杯形芳烃[4]芳烃的芳族和芳族位置上带有羟基的退火杯芳烃。

  摘要：

  通过在二甲苯中使合适的二聚体或四聚体与甲醛在二甲苯中进行非催化缩合反应，可以制备出在外位带有四个羟基的各种苯酚衍生的杯芳烃[4]芳烃（3），产率最高可达44％。X射线分析表明四叔丁基化合物（3a）具有两个分子内OH.O氢键的规则圆锥构象（与内异构体几乎相同），而相应的二聚体（6c）优选具有两个分子内OH.pi（芳烃）相互作用的构象（在杯芳烃中是不可能的）。用二溴甲基化的二聚体冷凝带有邻位游离位置的exo-calix [4]芳烃3f，g（可通过脱丁基容易制得），得到由内-和exo-calix [4]芳烃亚结构组成的双（9）和三（10）芳芳芳烃退火态产量分别高达24％和10％。分子动力学计算表明，9中的外杯芳烃部分比完全柔性的3瓶流动性差，而内杯芳烃部分则显示出比通常更高的迁移率。但是，不可能有一个完整的互变锥->锥，因此可以构建固有的手性分子。

  DOI：

  10.1021/jo9511197
• 作为产物：
  描述：

  4-叔丁基-2-[(5-叔-丁基-2-羟基-3-甲基苯基)甲基]-6-甲基苯酚 在 aluminum (III) chloride 作用下， 以 甲苯 为溶剂， 生成 bis[2-hydroxy-3-methylphenyl]methane
  参考文献：
  名称：

  Macrocyclic Nonviral Vectors: High Cell Transfection Efficiency and Low Toxicity in a Lower Rim Guanidinium Calix[4]arene

  摘要：

  New multivalent cationic lipids, one of them showing high efficiency and low toxicity in cell transfection, have been obtained by attaching guanidinium groups at the lower rim of calix[4]arenes.

  DOI：

  10.1021/ol801326d

文献信息

• Optically active compound and photosensitive resin composition
  申请人：——

  公开号：US20030211421A1

  公开（公告）日：2003-11-13

  A photoactive compound is used in combination with a photosensitizer, represented by the following formula (1): A −[( J ) m −( X-Pro )] n (1) wherein A represents a hydrophobic unit comprising at least one kind of hydrophobic groups selected from a hydrocarbon group and a heterocyclic group, J represents a connecting group, X-Pro represents a hydrophilic group protected by a protective group Pro which is removable by light exposure, m represents 0 or 1, and n represents an integer of not less than 1. The protective group Pro may be removable by light exposure in association with the photosensitizer (especially, a photo acid generator), or may be a hydrophobic protective group. The hydrophilic group may be a hydroxyl group or a carboxyl group. The photoactive compound has high sensitivity to a light source of short wavelength beams, for resist application, therefore, the photoactive compound is advantageously used for forming a pattern with high resolution.

  一种光活性化合物与光敏剂结合使用，由以下公式（1）表示： A −[( J ) m −( X-Pro )] n (1) 其中，A代表至少包括一种从烃基和杂环基中选择的疏水基的疏水单元，J代表连接基团，X-Pro代表由光照可去除的保护基团Pro保护的亲水基团，m代表0或1，n代表不少于1的整数。 保护基团Pro可以与光敏剂（特别是光酸发生剂）一起通过光照可去除，也可以是疏水保护基团。亲水基团可以是羟基或羧基。光活性化合物对短波长光源具有很高的敏感性，用于光刻应用，因此，该光活性化合物有利于形成具有高分辨率的图案。
• Sodium channel modulators
  申请人：——

  公开号：US20030027822A1

  公开（公告）日：2003-02-06

  The invention provides sodium channel modulating compounds of formula I: 1 wherein X, Y, Q, R 1 , w, and R 2 have any of the values defined in the specification, and salts thereof, which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of formula (I) or a salt thereof, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).

  该发明提供了公式I的钠通道调节化合物：1其中X、Y、Q、R1、w和R2具有规范中定义的任何值，以及其盐，这些化合物对于治疗与钠通道活性相关的疾病或症状，如神经病性疼痛，具有有用性。该发明还提供了包含公式(I)的化合物或其盐的药物组合物，以及包括将这种化合物或盐用于哺乳动物（例如人类）的治疗方法。
• MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME
  申请人：TABATA Masayoshi

  公开号：US20110224343A1

  公开（公告）日：2011-09-15

  The present invention provides a modifier for aromatic polyesters which enhances the melt fluidity of aromatic polyesters without a significant decrease in the heat resistance of the aromatic polyesters, and an aromatic polyester resin composition including the modifier for aromatic polyesters. The present invention relates to a modifier for aromatic polyesters comprising polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof, and the modifier comprises a material having a structure composed of a first residue selected from the group consisting of divalent residues represented by Formula (I): —Ar—W 1 x —Ar— and by Formula (II): —Ar—, the first residues being bonded to two identical or different second residues selected from the group consisting of monovalent residues represented by Formula (III): and monovalent residues represented by Formula (IV): —O—C(O)—R 7 —.

  本发明提供了一种用于芳香族聚酯的改性剂，可以增强芳香族聚酯的熔融流动性，而不明显降低芳香族聚酯的耐热性，以及包括该改性剂的芳香族聚酯树脂组合物。本发明涉及一种用于芳香族聚酯的改性剂，包括多羟基酚残基和芳香族多羧酸、酸卤或其酸酐残基，该改性剂包括具有以下结构的材料：第一残基，选择自由式(I)所代表的二价残基：—Ar—W1x—Ar—和自由式(II)所代表的：—Ar—，第一残基与选择自由式(III)所代表的单价残基：和自由式(IV)所代表的单价残基：—O—C(O)—R7—的两个相同或不同的第二残基结合。
• Multidentate phosphite ligands, catalytic compositions containing such ligands, and catalytic prosses utilizing such catalytic compositions
  申请人：——

  公开号：US20030023110A1

  公开（公告）日：2003-01-30

  Multidentate phosphite ligands are disclosed for use in reactions such as hydrocyanation and isomerization. The catalyst compositions made therefrom and the various catalytic processes which employ such multidentate phosphite ligands are also disclosed. In particular, the ligands have heteroatom-containing substituents on the carbon attached to the ortho position of the terminal phenol group.

  多齿磷酸酯配体被用于反应，如氢氰化和异构化。由此制成的催化剂组合物以及采用这些多齿磷酸酯配体的各种催化过程也被披露。特别是，这些配体在连接到末端酚基的邻位碳上具有含杂原子的取代基。
• Herbicidal and plant growth regulant activity of glyoxylates
  申请人：Fermenta ASC Corporation

  公开号：US04976770A1

  公开（公告）日：1990-12-11

  12H-dibenzo[d,g][1,3]dioxocin-6-carboxylic acid and certain derivatives thereof (glyoxylates) exhibit plant growth regulant and herbicidal activity when applied to a plant locus.

  12H-二苯并[d,g][1,3]二噁英-6-羧酸及其某些衍生物（乙二醛酸）在施加到植物位点时表现出植物生长调节剂和除草剂活性。