zinc(II) carbonate | 743369-26-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: zinc(II) carbonate
• 英文别名: zinc Carbonate；ZnCO₃；zinc;carbonate
• CAS: 743369-26-8
• 化学式: CO₃*Zn
• 分子量: 125.399
• InChiKey: FMRLDPWIRHBCCC-UHFFFAOYSA-L

物化性质

• 物理描述：
  Zinc carbonate appears as a white crystalline solid or powder that is insoluble in water. The primary hazard is the threat posed to the environment. Immediate steps should be taken to limit its spread to the environment. Used in pharmaceuticals, to make other zinc compounds, as a feed additive.
• 颜色/状态：
  WHITE RHOMBIC CRYSTALS
• 气味：
  Odorless
• 熔点：
  Loses CO 2 at 572° F = 300° F = 573.2° F (USCG, 1999)
• 溶解度：
  0.001 G/100 G OF WATER AT 15 °C; SOL IN DIL ACIDS, ALKALIES & SOLN OF AMMONIUM SALTS.
• 密度：
  4.398 at 68 °F (USCG, 1999)
• 自燃温度：
  Not flammable (USCG, 1999)
• 分解：
  When heated to decomp ... emits toxic fumes of /carbon monoxide and zinc/.
• 折光率：
  INDEX OF REFRACTION: 1.818, 1.618

计算性质

• 辛醇/水分配系数(LogP)：
  -2.45
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

代谢

锌可以通过肺部、皮肤和胃肠道进入人体。肠道对锌的吸收由锌载体蛋白CRIP控制。锌还与金属硫蛋白结合，帮助防止过量锌的吸收。锌广泛分布并在所有组织和组织液中找到，特别是在肝脏、胃肠道、肾脏、皮肤、肺、大脑、心脏和胰腺中。在血液中，锌存在于红细胞中的碳酸酐酶结合，以及血浆中的白蛋白、α2-巨球蛋白和氨基酸结合。白蛋白和氨基酸结合的锌可以扩散穿过组织膜。锌通过尿液和粪便排出体外。

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

缺铁性贫血是由于锌的过度吸收抑制了铜和铁的吸收，这很可能是通过肠道粘膜细胞的竞争性结合实现的。铜和锌与铜锌超氧化物歧化酶结合的不平衡水平与肌萎缩侧索硬化症（ALS）有关。胃酸能溶解金属锌，生成腐蚀性的氯化锌，这可能会损伤胃粘膜。金属烟雾热被认为是对吸入锌的免疫反应。（L48, L49, A49）

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

长期接触锌会导致贫血、运动失调、乏力，并降低体内的好胆固醇水平。还认为它会导致胰腺和生殖损害。

Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

吸入 (L49)；口服 (L49)；经皮 (L49)

Inhalation (L49) ; oral (L49) ; dermal (L49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

摄入大剂量的锌会导致胃痉挛、恶心和呕吐。急性吸入大量锌会引起金属烟雾热，其特征是寒战、发热、头痛、乏力、鼻和喉咙干燥、胸痛和咳嗽。锌与皮肤的接触会导致皮肤刺激。

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

来源:Toxin and Toxin Target Database (T3DB)

吸收、分配和排泄

研究了不同饮食锌含量对MOPC104E肿瘤负荷的Balb/c雌性小鼠锌吸收率以及组织中锌、钙和镁含量的影响。每组7只小鼠（每只小鼠接种约125万个MOPC104E细胞），分为三组，分别给予三种实验性饮食：适量锌饮食（40微克锌/克）、锌缺乏饮食（1.0微克锌/克）或锌过量饮食（1毫克锌/克）。另一组7只无肿瘤的小鼠作为对照组，喂食实验室小鼠饲料。锌缺乏饮食中含有37.5微克锌/克。对于适量锌饮食，向锌缺乏饮食中添加了71.0毫克锌碳酸盐/千克饮食。对于锌过量饮食，添加了1917.9毫克锌碳酸盐/千克饮食。在特殊饮食14天后，小鼠通过胃内给药的方式给予含有0.37 MBq (65)锌的200微升溶液（比活度：37 MBq/毫克）。通过伽马计数法测定各器官中的(65)Zn。另一组28只小鼠在上述相同实验条件下进行。在注射戊巴比妥麻醉后，通过原子吸收光谱法分析每个器官的锌、钙和镁含量。锌的吸收率与饮食中锌的含量成反比，且低于喂食实验室小鼠饲料的无肿瘤对照组小鼠。与对照小鼠相比，肿瘤负荷小鼠的锌含量也较低，但肿瘤中的锌含量，无论饮食中锌的含量如何，都高于宿主正常组织（胰腺除外）。

The effects of different amounts of dietary zinc on the zinc absorption rate and on zinc, calcium and magnesium concn in tissues of MOPC104E tumor bearing Balb/c female mice were determined. Three groups of 7 mice each (each mouse inoculated with approx 1.25 million MOPC104E cells) were given one of three experimental diets containing adequate amounts of zinc (40 ug zinc/g), a zinc deficient diet (1.0 ug zinc/g), or a zinc excess diet (1 mg zinc/g). A group of 7 nontumor bearing mice was fed laboratory mice chow as a control. The zinc deficient diet contained 37.5 ug zinc/g. For the zinc adequate diet, 71.0 mg zinc carbonate/kg diet was added to the zinc deficient diet. For the zinc excess diet 1917.9 mg zinc carbonate/kg diet was added. After 14 days on the special diets, mice were given an intragastric dose of a 200 ul solution containing 0.37 MBq (65)zinc (specific activity: 37 MBq/mg). (65)Zn was determined in various organs by gamma counting. Another set of 28 mice were placed in the same experimental conditions as described above. After anesthesia with nembutal injection, each organ was analyzed for concn of zinc, calcium, and magnesium by atomic absorption spectrophotometry. The zinc absorption rate was inversely related to the amounts of zinc in the diet and was lower than that of nontumor bearing control mice fed a laboratory mice chow. Zinc concn of tumor bearing mice were also low compared with control mice but tumor zinc concn, regardless of the concn of zinc in the diets, were higher than those of normal tissues of the host other than the pancreas.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  zinc(II) carbonate 生成 锌
  参考文献：
  名称：

  某些含有ONO三齿Schiff碱配体的过渡金属配合物的合成，光谱，配位和生物学活性。

  摘要：

  本文的主要目的是通过热分解过程获得以H2L Schiff碱配合物为前体的金属氧化物（MO）纳米颗粒的制备和表征的有趣数据。由2-[（2-羟基-萘-1-基亚甲基）-氨基合成了五种Mn（II），Co（II），Ni（II），Cu（II）和Zn（II）的席夫碱金属离子]-苯甲酸新加合物（H2L）。使用红外，电子，质谱和（1）H NMR光谱技术对这些配合物进行表征。元素分析数据证实（金属：H 2 L）的化学计量为1：1摩尔比。摩尔电导表明所有配合物都是非电解的。这些配合物的一般化学式为[M（L）（NH3）]·nH2O。所有复合物均为四面体几何。使用热重分析（TG / DTG）和差热分析（​​DTA）在氮气氛下讨论了H2L水合和无水配合物的热分解行为。使用X射线衍射仪（XRD）和扫描电子显微镜（SEM）检查反应产物的结晶相。

  DOI：

  10.1016/j.saa.2015.05.005
• 作为产物：
  描述：

  zinc(II) sulfate 在 alkali carbonate or alkali bicarbonate 作用下， 以 水 为溶剂， 生成 zinc(II) carbonate
  参考文献：
  名称：

  Kraut, Zeitschrift fur anorganische Chemie, 1897, vol. 13, p. 12 - 12

  摘要：

  DOI：
• 作为试剂：
  描述：

  氟乙酸 在 zinc(II) carbonate 作用下， 以 水 为溶剂， 生成 zinc di-(fluoroacetate)
  参考文献：
  名称：

  Salts of zinc and aliphatic haloid carboxylic acids for therapy of skin neoplasms and visible mucous coats

  摘要：

  该发明涉及医学，更具体地说是皮肤病学，即锌和脂肪族卤代羧酸的新盐，可用于治疗良性皮肤病变和可见的粘膜。提议以下锌和脂肪族卤代羧酸盐的化学式 其中在化学式中，氟（F）、氯（Cl）、溴（Br）或碘（I）可以是卤素原子。获得的技术结果是创造一种独特的制剂，用于治疗良性皮肤病变和可见的粘膜。该制剂低毒、作用迅速，具有明显的治疗效果和良好的耐受性。在治疗过程中不会引起并发症，并确保愈合时不形成疤痕组织。所创造的制剂允许扩展治疗类似疾病的药物种类。

  公开号：

  EP1746082A1

文献信息

• Thermal decomposition of carbonates, carboxylates, oxalates, acetates, formates, and hydroxides
  作者：Jacob Mu、D.D. Perlmutter

  DOI：10.1016/0040-6031(81)80175-x

  日期：1981.11

  Abstract A study is reported of the controlled decomposition of various metal carbonates, carboxylates, oxalates, acetates, formates and hydroxides and their common hydrates, carried out in a thermogravimetric analyzer, a differential scanning calorimeter, and a differential thermal analyzer. Various sample sizes, heating rates, and ambient atmospheres were used to demonstrate their influence on the

  摘要 报道了在热重分析仪、差示扫描量热仪和差示热分析仪中进行的各种金属碳酸盐、羧酸盐、草酸盐、乙酸盐、甲酸盐和氢氧化物及其常见水合物的受控分解的研究。使用各种样品尺寸、加热速率和环境气氛来证明它们对结果的影响。给出了中间化合物、每种化合物的分解温度范围和反应动力学的结果。
• Structurally diverse coordination compounds of zinc as effective precursors of zinc oxide nanoparticles with various morphologies
  作者：Marcin Swiatkowski、Rafal Kruszynski

  DOI：10.1002/aoc.4812

  日期：2019.4

  structurally diverse coordination compounds of zinc were designed and synthesized using two types of building blocks: short‐chain carboxylate ions and hexamethylenetetraamine. They were characterized by X‐ray crystallography, infrared spectroscopy and thermal analysis. The studied compounds were used as precursors for production (via controlled thermal conversion) of zinc oxide nanoparticles. The conversion

  锌的结构多样的配位化合物是使用两种类型的构件设计和合成的：短链羧酸根离子和六亚甲基四胺。它们通过X射线晶体学，红外光谱和热分析进行了表征。所研究的化合物用作生产（通过控制热转化）氧化锌纳米颗粒的前体。根据两个参数（加热速率和最高温度）对转化过程进行了优化。这种方法与适当的前体结构设计相结合，可以制造出各种氧化锌微粒和纳米颗粒。研究和讨论了前驱体结构和转化参数的改变对ZnO颗粒尺寸和形貌的影响。
• The Structure of Active Sites in Me–V–O Catalysts (Me = Mg, Zn, Pb) and Its Influence on the Catalytic Performance in the Oxidative Dehydrogenation (ODH) of Propane
  作者：P Rybarczyk、H Berndt、J Radnik、M.-M Pohl、O Buyevskaya、M Baerns、A Brückner

  DOI：10.1006/jcat.2001.3251

  日期：2001.8

  Me–V–O catalysts (Me = Mg, Zn, Pb) of different Me : V ratios were characterized with respect to phase composition, structure and valence state of vanadium sites as well as composition and acid–base properties of the surface using XRD, TEM, TPR, TPD/TPRS, FTIR, potentiometric titration, XPS, EPR, and UV/VIS-DRS. The latter two techniques were also applied in situ under catalytic reaction conditions

  使用X射线衍射分析了不同Me：V比的Me –V–O催化剂（Me = Mg，Zn，Pb）相对于钒部位的相组成，结构和价态以及表面的组成和酸碱性质，TEM，TPR，TPD / TPRS，FTIR，电位滴定，XPS，EPR和UV / VIS-DRS。后两种技术也在催化反应条件下原位应用。通过比较催化剂的表征结果和催化测试的结果，得出以下结构反应性关系：V 5+和V 4+均催化丙烷的ODH。然而，V 4+似乎比V 5+更具选择性，但活性更高。与VO 4四面体相比，八面体或方形锥体配位的V位更活跃，但选择性更低。分别存在于晶体金属原酸盐和丙酮酸盐中的分离的VO 4和V 2 O 7单元比无定形簇甚至晶体链或层状结构中的VO x物种更具选择性，但活性较低。由不同金属阳离子引起的催化性能差异不仅受金属阳离子的氧化电势控制，而且在很大程度上受酸碱性能，晶体尺寸和结构紊乱程度的影响。Me的催化活性和选择性–V–O催化剂按Mg>
• Cation Distribution and Local Configuration of Fe2+ Ions in Structurally Nonequivalent Lattice Sites of Heterometallic Fe(II)/M(II) (M = Mn, Co, Ni, Cu, Zn) Diaquadiformato Complexes
  作者：M. Devillers、J. Ladrière

  DOI：10.1006/jssc.1993.1092

  日期：1993.3

  57Fe Mössbauer investigations are carried out on a wide series of heterometallic diaquadiformato Fe(II)/M(II) complexes with M = Mn, Co, Ni, Cu, and Zn to provide a local picture of the coordination environment of the 57Fe2+ ions as a function of (i) the nature of the host cation and (ii) the relative amounts of both metals in the matrix (between 50 and 0.25 at.% Fe). Information is obtained on the

  57次铁穆斯堡尔调查是对广泛系列异金属diaquadiformato的情况下进行的Fe（II）/中号（II）配合物中号=锰，钴，镍，铜，锌，以提供的配位环境的局部图像57的Fe 2+离子作为宿主阳离子和（ii）的相对量在基质两种金属的（50和0.25之间。％的Fe）的（i）的性质的函数。获得有关两种金属在两个结构上不等价的晶格位点之间的定量分布以及每个晶体位点中掺杂原子周围的局部几何结构的信息。在混合的Fe-Cu络合物中。的Fe 2+离子在tetrahydrated站点优先结合; 在铜富含Fe的XCu 1- x（HCO 2）2 ·2H 2 O，位于六甲酸酯配位位的57 Fe 2+离子被甲酸酯配体的轴向压缩八面体包围，这与在纯铁化合物和在其他混合系统中。根据四极分裂值的温度依赖性，提出了四方场分裂和金属-配体相互作用程度的半定量估计。
• Synthesis and characterization of new metal(II) complexes with formates and some nitrogen donor ligands
  作者：D. Czakis-Sulikowska、A. Czylkowska、J. Radwańska-Doczekalska、R. Grodzki、E. Wojciechowska

  DOI：10.1007/s10973-006-7980-9

  日期：2007.11

  New mixed-ligands complexes with empirical formulae: M(2,4′-bpy)2L2·H2O (M(II)Zn, Cd), Zn(2-bpy)3L2·4H2O, Cd(2-bpy)2L2·3H2O, M(phen)L2·2H2O (where M(II)=Mn, Ni, Zn, Cd; 2,4′-bpy=2,4′-bipyridine, 2-bpy=2,2′-bipyridine, phen=1,10-phenanthroline, L=HCOO−) were prepared in pure solid state. They were characterized by chemical, thermal and X-ray powder diffraction analysis, IR spectroscopy, molar conductance in MeOH, DMF and DMSO. Examinations of OCO− absorption bands suggest versatile coordination behaviour of obtained complexes. The 2,4′-bpy acts as monodentate ligand; 2-bpy and phen as chelating ligands. Thermal studies were performed in static air atmosphere. When the temperature raised the dehydration processes started. The final decomposition products, namely MO (Ni, Zn, Cd) and Mn3O4, were identified by X-ray diffraction.

  新型的混合配体配合物，其经验公式为：M(2,4′-bpy)2L2·H2O (M(II)=Zn, Cd), Zn(2-bpy)3L2·4H2O, Cd(2-bpy)2L2·3H2O, M(phen)L2·2H2O (其中 M(II)=Mn, Ni, Zn, Cd; 2,4′-bpy=2,4′-联吡啶，2-bpy=2,2′-联吡啶，phen=1,10-菲啰啉，L=HCOO−) 在纯固态中制备。这些配合物通过化学、热分析和X射线粉末衍射分析、红外光谱、在MeOH、DMF和DMSO中的摩尔电导率进行了表征。OCO−吸收带的检测表明所得配合物具有多样的配位行为。2,4′-bpy作为单齿配体；2-bpy和phen作为螯合配体。热研究在静态空气氛围中进行。当温度升高时，脱水过程开始。最终分解产物，即MO (Ni, Zn, Cd) 和 Mn3O4，通过X射线衍射鉴定。