4-Aminobutyl nitrate | 2153-95-9

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: 4-Aminobutyl nitrate
• CAS: 2153-95-9
• 化学式: C₄H₁₀N₂O₃
• 分子量: 134.135
• InChiKey: ZWWGDWDSFUUNLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  81.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  丙半胱氨酸 、 4-Aminobutyl nitrate 在 焦碳酸二乙酯 作用下， 生成 (4R)-N-(4-Nitrooxybutyl)-2-oxothiazolidine-4-carboxamide
  参考文献：
  名称：

  Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties

  摘要：

  To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00199-9
• 作为产物：
  描述：

  4-氨基-1-丁醇 在 硝酸 作用下， 生成 4-Aminobutyl nitrate
  参考文献：
  名称：

  Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties

  摘要：

  To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00199-9

文献信息

• Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization
  作者：Gloria V. López、Fabiana Blanco、Paola Hernández、Ana Ferreira、Oscar E. Piro、Carlos Batthyány、Mercedes González、Homero Rubbo、Hugo Cerecetto

  DOI：10.1016/j.bmc.2007.06.019

  日期：2007.9

  mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic-hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.

  报道了一系列具有NO释放能力的α-生育酚模拟物的合成，物理化学和生物学特性。所选的NO供体部分是硝基氧基和呋喃喃。测试了所有产品的体外NO释放能力，血管舒张特性和哺乳动物细胞毒性活性。还评估了所有产品的亲脂-亲水平衡。一种新的杂氧呋喃杂酚衍生物，苯酚衍生物17，具有足够的研究性质。
• Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties
  作者：Sadao Ishihara、Fujio Saito、Yasuo Ohhata、Marie Kanai、Hiroshi Mizuno、Michio Fujisawa、Ryosuke Yorikane、Hiroyuki Koike

  DOI：10.1016/s0960-894x(03)00199-9

  日期：2003.5

  To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation. (C) 2003 Elsevier Science Ltd. All rights reserved.