1,2-二(2-苄氨基乙氧基)乙烷 | 66582-26-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,2-二(2-苄氨基乙氧基)乙烷
• 中文别名: 乙二醇双(2-苄基氨乙基)醚；1,2-双(2-苄氨基乙氧基)乙烷；1,2-双(2-苄胺乙氧基)乙烷；1,10-二苄基-4,7-二氧杂-1,10-二氮杂癸烷
• 英文名称: 1,10-dibenzyl-4,7-dioxa-1,10-diazadecane
• 英文别名: N,N'-dibenzyl-2,2'-(ethylenedioxy)bis(ethylamine)；N,N'-dibenzyl-3,6-dioxaoctane-1,8-diamine；1,10-dibenzyl-4,7-dioxa-1,10-diazadecan；1,2-bis-(2-benzylamino-ethoxy)-ethane；1,2-bis(2-benzylaminoethoxy)ethane；N-benzyl-2-[2-[2-(benzylamino)ethoxy]ethoxy]ethanamine
• CAS: 66582-26-1
• 化学式: C₂₀H₂₈N₂O₂
• mdl: MFCD00191390
• 分子量: 328.455
• InChiKey: FQEGBHFZAGTXDY-UHFFFAOYSA-N

物化性质

• 密度：
  1.05
• 稳定性/保质期：
  远离氧化物、阳光、热源、明火、高温、火花及静电电荷和其他点火源。

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  42.5
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2922199090
• 储存条件：
  存放在密封容器内，并置于阴凉、干燥处。储存时需远离氧化剂，避免光照，在常温下保存。

SDS

1,2-Bis(2-benzylaminoethoxy)ethane
SAFETY DATA SHEET

---

Section 1. IDENTIFICATION OF THE SUBSTANCE OR MIXTURE AND OF THE SUPPLIER
Product name: 1,2-Bis(2-benzylaminoethoxy)ethane

---

Section 2. HAZARDS IDENTIFICATION
Classification of the GHS
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS
Category 2
Skin corrosion/irritation
Serious eye damage/eye irritation Category 2A
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements
Pictograms or hazard symbols
Signal word Warning
Hazard statement Causes skin irritation
Causes serious eye irritation
Precautionary statements
[Prevention] Wash hands thoroughly after handling.
Wear protective gloves/eye protection/face protection.
[Response] IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN: Gently wash with plenty of soap and water.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.

---

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Component(s): 1,2-Bis(2-benzylaminoethoxy)ethane
Percent: >90.0%(GC)
CAS Number: 66582-26-1
Synonyms: 1,10-Dibenzyl-4,7-dioxa-1,10-diazadecane , Ethylene Glycol Bis(2-benzylaminoethyl)
Ether
C20H28N2O2
Chemical Formula:

---

Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
1,2-Bis(2-benzylaminoethoxy)ethane

---

Section 4. FIRST AID MEASURES
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

---

Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Extinguishing media not to Solid streams of water
be used:
Specific hazards: Take care as it may decompose upon combustion or in high temperatures to
generate poisonous fume.
Specific methods: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

---

Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in a suitable absorbent (e.g. rag, dry sand, earth, saw-dust).
containment and cleaning In case of large amount of spillage, contain a spill by bunding. Adhered or collected
up: material should be promptly disposed of, in accordance with appropriate laws and
regulations.

---

Section 7. HANDLING AND STORAGE
Handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapor or mist. Wash hands and face thoroughly after handling.
Use a ventilation, local exhaust if vapor or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Storage
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store away from incompatible materials such as oxidizing agents.
Packaging material: Law is followed.

---

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

---

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Liquid
Physical state (20°C):
Form: clear
1,2-Bis(2-benzylaminoethoxy)ethane

---

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Color: Pale yellow - Yellow green
Odor: No data available
pH: No data available
Melting point/freezing point:No data available
Boiling Point/Range: No data available
Flash Point: No data available
Explosive limits
No data available
Lower:
Upper: No data available
1.05
Density:
Solubility: No data available

---

Section 10. STABILITY AND REACTIVITY
Stability: Stable under proper conditions.
Reactivity: No special reactivity has been reported.
Incompartible materials: oxidizing agents
Hazardous Decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)
Products:

---

Section 11. TOXICOLOGICAL INFORMATION
No data available
Acute Toxicity:
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
No data available
IARC =
NTP = No data available
No data available
Reproductive toxicity:

---

Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
Crustacea: No data available
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative No data available
potential(BCF):
Mobillity in soil
log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law No data available
constant(PaM3/mol):

---

Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

---

Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not Listed
1,2-Bis(2-benzylaminoethoxy)ethane

---

Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26,
2002): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were
prescribed.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1,2-二(2-苄氨基乙氧基)乙烷 在 palladium 10% on activated carbon 、 甲酸铵 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 22.0h， 生成 1,2-bis(N-tert-butoxycarbonylmethyl-2-aminoethoxy)ethane
  参考文献：
  名称：

  一种钙离子响应的双模式磁共振成像探针及 其制备方法

  摘要：

  一种钙离子响应的双模式磁共振成像探针及其制备方法。双模式磁共振成像探针以2,2'‑(乙烯二氧)双(乙胺)为骨架，在骨架上修饰羧酸衍生物和含有酰胺结构的含氟基团。将2,2'‑(乙烯二氧)双(乙胺)溶于甲醇中，再加入苯甲醛回流反应后加入硼氢化钠，得苄基保护的溶液，再溶于二氯甲烷中，加入溴乙酸叔丁酯和N，N‑二异丙基乙胺后反应，得具有羧酸衍生物修饰的产物，再溶于甲醇中，加入钯碳和甲酸铵后回流反应，得脱去N苄基保护的具有仲氨结构的产物，再溶于二氯甲烷中，加入2‑溴‑氮‑(2,2,2‑三氟乙基)乙酰胺和N，N‑二异丙基乙胺后反应，再通过三氟乙酸脱去两个叔丁酯保护后，溶于水，加入MnCl2反应后即得。

  公开号：

  CN109529057B
• 作为产物：
  描述：

  N-[2-[2-[2-(benzylideneamino)ethoxy]ethoxy]ethyl]-1-phenylmethanimine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以87%的产率得到1,2-二(2-苄氨基乙氧基)乙烷
  参考文献：
  名称：

  一种钙离子响应的双模式磁共振成像探针及 其制备方法

  摘要：

  一种钙离子响应的双模式磁共振成像探针及其制备方法。双模式磁共振成像探针以2,2'‑(乙烯二氧)双(乙胺)为骨架，在骨架上修饰羧酸衍生物和含有酰胺结构的含氟基团。将2,2'‑(乙烯二氧)双(乙胺)溶于甲醇中，再加入苯甲醛回流反应后加入硼氢化钠，得苄基保护的溶液，再溶于二氯甲烷中，加入溴乙酸叔丁酯和N，N‑二异丙基乙胺后反应，得具有羧酸衍生物修饰的产物，再溶于甲醇中，加入钯碳和甲酸铵后回流反应，得脱去N苄基保护的具有仲氨结构的产物，再溶于二氯甲烷中，加入2‑溴‑氮‑(2,2,2‑三氟乙基)乙酰胺和N，N‑二异丙基乙胺后反应，再通过三氟乙酸脱去两个叔丁酯保护后，溶于水，加入MnCl2反应后即得。

  公开号：

  CN109529057B

文献信息

• Convenient synthesis of crown ethers containing a hydrazine moiety
  作者：Jerald S. Bradshaw、Krzysztof E. Krakowiak、Geng Wu、Reed M. Izatt

  DOI：10.1016/s0040-4039(00)80819-9

  日期：1988.1

  A new class of crown ethers containing a hydrazine moiety was synthesized in only 2, 3, or 4 steps starting from 1,2-diacetylhydrazine or 1,2-diethylhydrazine. Hydrazino-crown ethers with 2 or 4 nitrogen atoms in the ring were obtained by reacting the hydrazine derivatives with 1,11-diiodo-(or dichloro)-3,6,9-trioxaundecane, 4-allyloxymethyl-1,8-diiodo-3,6-dioxaoctane, 3-chloro-2-chloromethyl-1-propene

  从1,2-二乙酰肼或1,2-二乙基肼开始，仅用2、3或4个步骤就合成了一种新的含有肼部分的冠醚。通过使肼衍生物与1,11-二碘-（或二氯）-3,6,9-三氧杂十一烷，4-烯丙氧基甲基-1,8-二碘- 3,6-二氧杂辛烷，3-氯-2-氯甲基-1-丙烯，1,10-二苄基-1,10-二氮杂-3,7-二氧杂十二烷或二甘氨酰二氯化物（随后还原）。二氮杂肼基19-冠-6化合物与甲基氯化铵形成络合物。
• Novel synthetic access to 15- and 18-membered ring diaza-bibracchial lariat ethers (BiBLEs) and a study of sidearm-macroring cooperativity in cation binding
  作者：Vincent J. Gatto、Kristin A. Arnold、Anthony M. Viscariello、Steven R. Miller、George W. Gokel

  DOI：10.1016/s0040-4039(00)84009-5

  日期：1986.1

  An extremely practical synthesis of 4,10-diaza-15-crown-5, 4,13-diaza-18-crown-6, and symmetrically N,N′-disubstituted derivatives thereof, is presented along with the first survey of cation binding data for the 15-membered ring systems.

  提出了一种非常实用的4,10-diaza-15-crown-5、4,13-diaza-18-crown-6及其对称的N，N'-二取代衍生物的合成方法，以及首次进行的阳离子结合研究15元环系统的数据。
• Stereoselective syntheses of tri- and tetrapeptide analogues by dynamic resolution of α-halo amides in nucleophilic substitution
  作者：Ji-yeon Chang、Eun-kyoung Shin、Hyun Jung Kim、Yangmee Kim、Yong Sun Park

  DOI：10.1016/j.tet.2005.01.091

  日期：2005.3

  Dynamic resolution of α-bromo and α-chloro acetamides in nucleophilic substitution with amine nucleophiles in the presence of TBAI has been investigated for stereoselective syntheses of tri- and tetrapeptide analogues. Mechanistic investigations suggest that primary pathway of the asymmetric induction is a dynamic kinetic resolution and real intermediate for the substitution is α-iodo acetamides. Also

  对于三肽和四肽类似物的立体选择性合成，已经研究了在存在TBAI的情况下用胺类亲核试剂进行亲核取代中的α-溴和α-氯乙酰胺的动态拆分。机理研究表明，不对称诱导的主要途径是动态动力学拆分，取代的真正中间产物是α-碘乙酰胺。同样，证明了这种温和而简单的方法在N-羧烷基，N-氨基烷基和N-羟烷基肽类似物的立体选择性制备中的应用。
• Evaluation of Binding Selectivities of Caged Crown Ligands toward Heavy Metals by Electrospray Ionization/Quadrupole Ion Trap Mass Spectrometry
  作者：Sheryl M. Blair、Jennifer S. Brodbelt、Alan P. Marchand、Kaipenchery A. Kumar、Hyun-Soon Chong

  DOI：10.1021/ac991125t

  日期：2000.6.1

  mass spectrometry is used to evaluate the heavy metal binding selectivities of five caged crown ethers and two polyether reference compounds in methanol solution. The binding preferences for Hg2+, Pb2+, Cd2+, and Cu2+ were analyzed by comparison of ESI mass spectral intensities with the aim of developing this method for the rapid screening of binding selectivities of new synthetic ligands. The cage compounds

  电喷雾电离（ESI）/四极离子阱质谱用于评估甲醇溶液中5个笼状冠醚和2个聚醚参考化合物的重金属结合选择性。通过比较ESI质谱强度来分析Hg2 +，Pb2 +，Cd2 +和Cu2 +的结合偏好，目的是开发这种方法来快速筛选新的合成配体的结合选择性。笼型化合物优先与Hg2 +结合，但笼型隐窝衍生物偏爱Pb2 +。对Hg2 +的偏爱源于氮或硫原子对于Hg2 +的线性配位的有利定位，而穴状衍生物因其较大的空穴尺寸而偏爱Pb2 +。
• Metal-directed self-assembly of bimetallic dithiocarbamate transition metal cryptands and their binding capabilitiesElectronic supplementary information (ESI) available: selected experimental procedures. See http://www.rsc.org/suppdata/cc/b3/b308629a/
  作者：Paul D. Beer、Neil G. Berry、Andrew R. Cowley、Elizabeth J. Hayes、Edward C. Oates、Wallace W. H. Wong

  DOI：10.1039/b308629a

  日期：——

  A novel family of redox-active dinuclear transition metal based cryptands self-assembled from dithiocarbamate ligands has been synthesised; depending upon the nature of the spacer groups these new cryptand systems have been shown to electrochemically recognise the binding of cations or anions.

  由二硫代氨基甲酸酯配体自组装而成的新型氧化还原活性二核过渡金属基隐色体系列已经合成；根据间隔基团的性质，这些新的隐色体系统已被证明可以电化学识别阳离子或阴离子的结合。

表征谱图